Trizol (总RNA抽提试剂)(R0016)

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Trizol (总RNA抽提试剂)

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产品编号: R0016

产品包装:100ml

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价格: ¥ 589.00

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产品编号	产品名称	产品包装	产品价格
R0016	Trizol (总RNA抽提试剂)	100ml	589.00元

碧云天生产的Trizol是一种用于细胞或组织总RNA抽提的试剂。本产品采用和Invitrogen公司的TRIzol完全相似的原理和方法，抽提的方法和步骤完全相同。
Trizol的颜色和TRIzol相同，加入氯仿后上层呈无色，下层呈紫红色，便于吸取上层水相。
Trizol对动植物细胞或组织及细菌的总RNA抽提均适用。
Trizol可以抽提长达15 kb的RNA，也可以抽提microRNA等小RNA。抽提小RNA时宜-70℃沉淀过夜。
Trizol抽提所得RNA无DNA和蛋白污染。一般所得RNA溶于DEPC水后的A260/280值为1.8-2.0。
裂解细胞或和组织共匀浆时，Trizol可以保持样品中RNA的完整性，即可以有效抑制RNA的降解。
每一百万细胞用Trizol抽提可得5-15μg RNA；每毫克组织用Trizol抽提可得1-10μg RNA。产量因细胞和组织不同而异。
抽提两个样品约需一小时。
Trizol抽提所得RNA可直接用于Northern，点杂交，纯化mRNA，体外翻译，RNase protection assay，cDNA克隆，以及RT-PCR；也可以用于基因表达芯片分析、高通量测序(deep sequencing)等对RNA质量要求较高的情况。
碧云天生产的Beyozol(R0011)和Trizol(R0016)的成分有细微差别，实际抽提效果无任何显著差异。
每100ml Trizol可以抽提100个六孔板中的样品或100个50-80mg的组织样品。
包装清单：

产品编号	产品名称	包装
R0016	Trizol	100ml
—	说明书	1份

保存条件：
4℃保存，一年有效。
注意事项：
需自备氯仿，异丙醇，DEPC，75%乙醇(DEPC水配制)，和DEPC水。DEPC(ST036)，DEPC水(R0021)可向碧云天订购。
所有离心管，枪头及相关溶液都必须无RNA酶污染。耐高温器物可150℃烘烤4小时以去除RNA酶，其它器物去除RNA酶可考虑用0.01%的DEPC水浸泡过夜，然后灭菌，烘干。溶液需用DEPC水配制。加0.01%(体积比) diethylpyrocarbonate(DEPC)至重蒸水或Milli-Q级水中，处理过夜，灭菌即成DEPC水。
使用冻存的细胞或组织抽提总RNA的效果通常比新鲜的细胞或组织差一些。因为在细胞或组织冻融过程中一些细胞或组织内的RNase会被释放出来并剪切样品。如果不能及时抽提RNA，推荐先加入适量Trizol，并裂解样品后冻存。
必须戴一次性手套操作，且尽量不要对着RNA样品呼气或说话，以防RNA酶污染。建议戴一次性口罩操作。
Trizol含有毒物质苯酚，避免接触皮肤或吸入。为防止溅入眼睛，请戴防护眼镜或使用透明保护屏。如皮肤接触Trizol，请立即用大量去垢剂和水冲洗，如仍有不适，请听取医生意见。
Trizol抽提总RNA的同时，理论上也可抽提蛋白和DNA，但未经测试。有兴趣者可按Invitrogen公司的TRIzol的操作步骤进行操作。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：
1. 细胞裂解或组织匀浆。
a. 贴壁细胞
吸尽培养液，每10平方厘米细胞加入1ml Trizol。一般六孔板每孔加1ml Trizol，12孔板每孔加0.5ml Trizol。晃动3-5下，再用枪吹打2-3下，确保全部裂解，然后吸至离心管中。
b. 悬浮细胞
离心收集细胞，吸尽液体，每五百万至一千万动植物或酵母细胞，或一千万细菌，加入1ml Trizol。用枪吹打或适当vortex，确保全部裂解。某些酵母和细菌如裂解不充分，可用匀浆器匀浆，确保全部裂解。
c. 组织
先将组织剪切成小块，放入普通玻璃匀浆器内。每50mg-80mg组织加入1ml Trizol，匀浆。对于RNA完整性要求比较高的情况，推荐先液氮冷冻组织块，然后在低温下用研钵研碎组织，随后再加入Trizol进行总RNA抽提。
2. 对于某些蛋白，多糖或脂含量很高的细胞或组织，Trizol裂解后可能会有不溶物或油脂状漂浮物。需12,000g 4℃离心10分钟，然后吸取澄清的Trizol裂解产物至一新的离心管中。
3. 室温放置5分钟，使样品充分裂解。
4. 每毫升 Trizol加入0.2ml氯仿，vortex混匀或猛烈晃动15秒，室温放置2-3分钟。
5. 12,000g 4℃离心15分钟，然后吸取含总RNA的上层无色水相至一新的离心管中，每毫升Trizol约可吸取0.5-0.55ml。
6. 按每毫升最初的Trizol加入0.5ml异丙醇，颠倒数次混匀，室温沉淀10分钟。如果希望提取microRNA等小RNA，推荐-70℃沉淀过夜。
7. 12,000g 4℃离心10分钟，在管底可见RNA沉淀，弃上清。
8. 每毫升最初的Trizol加入1ml 75%乙醇(DEPC水配制)，vortex或颠倒混匀，
9. 7,500g 4℃离心5分钟，弃上清。再用离心机甩一下（>5,000rpm, 离心1秒），小心吸尽液体。
10. 待RNA略干后，加入20μl DEPC水溶解，-70℃冻存。注意：切勿让RNA过分干燥，否则将极难溶解，且测出的A260/280值会低于1.6。

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66. Cao Y, Song J, Ge J, Song Z, Chen J, Wu C

MicroRNA-100 suppresses human gastric cancer cell proliferation by targeting CXCR7.

Oncol Lett. 2018 Jan;15(1):453-458. (IF 2.311)

67. Gao X, Zhao H, Diao C, Wang X, Xie Y, Liu Y, Han J, Zhang M

miR-455-3p serves as prognostic factor and regulates the proliferation and migration of non-small cell lung cancer through targeting HOXB5.

BIOCHEM BIOPH RES CO. 2018 Jan 1;495(1):1074-1080. (IF 2.985)

68. Jiang S, Liu X, Li D, Yan M, Ju C, Sun J, Jiang F

Study on Attenuating Angiogenesis and Epithelial-Mesenchymal Transition (EMT) of Non-Small Cell Lung Carcinoma (NSCLC) by Regulating MAGEC2.

TECHNOL CANCER RES T. 2018 Jan 1;17:1533033818797587. (IF 2.074)

69. Li Y, Zhang Z, Zhang Z.

Porous Chitosan/Nano-Hydroxyapatite Composite Scaffolds Incorporating Simvastatin-LoadedPLGA Microspheres for Bone Repair.

Cells Tissues Organs. 2018 Feb 1. (IF 2.064)

70. Yang Z, Cheng F, Yan G, Xiong L, Liu H

Propofol protects against endotoxin-induced myocardial injury by inhibiting NF-κB-mediated inflammation.

Exp Ther Med. 2018 Feb;15(2):2032-2036. (IF 1.785)

71. Ling H, Zhu Z, Yang J, He J, Yang S, Wu D, Feng S, Liao D

Dihydromyricetin improves type 2 diabetes-induced cognitive impairment via suppressing oxidative stress and enhancing brain-derived neurotrophic factor-mediated neuroprotection in mice.

ACTA BIOCH BIOPH SIN. 2018 Mar 1;50(3):298-306. (IF 2.836)

72. Zhang B, Yu Y, Aori G, Wang Q, Kong D, Yang W, Guo Z, Zhang L

Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting Inflammation.

EVID-BASED COMPL ALT. 2018 Mar 11;2018:2789847. (IF 1.813)

73. Zhang L, Wang C, Xi Z, Li D, Xu Z

Mercaptoethanol Protects the Aorta from Dissection by Inhibiting Oxidative Stress, Inflammation, and Extracellular Matrix Degeneration in a Mouse Model.

MED SCI MONITOR. 2018 Mar 28;24:1802-1812. (IF 1.918)

74. Hao P, Kang B, Yao G, Hao W, Ma F

MicroRNA-211 suppresses prostate cancer proliferation by targeting SPARC.

Oncol Lett. 2018 Apr;15(4):4323-4329. (IF 2.311)

75. Liu R, Diao J, He S, Li B, Fei Y, Li Y, Fang W

XQ-1H protects against ischemic stroke by regulating microglia polarization through PPARγ pathway in mice.

Int Immunopharmacol. 2018 Apr;57:72-81. (IF 3.943)

76. Li Y, Zhang ZZ

Sustained curcumin release from PLGA microspheres improves bone formation under diabetic conditions by inhibiting the reactive oxygen species production.

DRUG DES DEV THER. 2018 May 24;12:1453-1466. (IF 3.216)

77. Sun Y, Wang Y, Yang H, Xu Y, Yu H

miR-455-3p functions as a tumor suppressor in colorectal cancer and inhibits cell proliferation by targeting TPT1.

INT J CLIN EXP PATHO. 2018 May 1;11(5):2522-2529. eCollection 2018. (IF 0.252)

78. Liu L, Lai X, Yuan C, Lv X, Yu T, He W, Liu J, Zhang H

Aberrant expression of miR-153 is associated with the poor prognosis of cervical cancer.

Oncol Lett. 2018 Jun;15(6):9183-9187. (IF 2.311)

79. Wang P, Chen Y, Wang L, Wu Y, Wang L, Wu Y, Gong Z

The intervention mechanism of folic acid for benzo(a)pyrene toxic effects in vitro and in vivo.

Eur J Cancer Prev. 2018 Jul 16. (IF 2.413)

80. Song S, Yu W, Lin S, Zhang M, Wang T, Guo S, Wang H

LncRNA ADPGK-AS1 promotes pancreatic cancer progression through activating ZEB1-mediated epithelial-mesenchymal transition.

Cancer Biol Ther. 2018 Jul 3;19(7):573-583. (IF 3.659)

81. Zhao ZW, Zhang M, Chen LY, Gong D, Xia XD, Yu XH, Wang SQ, Ou X, Dai XY, Zheng XL, Zhang DW, Tang CK

Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway.

BBA-MOL CELL BIOL L. 2018 Aug;1863(8):806-822. (IF 4.519)

82. Zheng X, Zhang Y, Guo S, Zhang W, Wang J, Lin Y

Dynamic expression of matrix metalloproteinases 2, 9 and 13 in ovariectomy-induced osteoporosis rats.

Exp Ther Med. 2018 Sep;16(3):1807-1813. (IF 1.785)

83. Xu H, Liu F

Downregulation of FOXP1 correlates with tendon stem/progenitor cells aging.

BIOCHEM BIOPH RES CO. 2018 Sep 26;504(1):96-102. (IF 2.985)

84. Li Z, Zeng G, Zheng X, Wang W, Ling Y, Tang H, Zhang J

Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons.

Biomed Pharmacother. 2018 Oct;106:349-354. (IF 4.545)

85. Que W, Liu H, Yang Q, Xu S

Antiproliferation activities of NK4 on multiple myeloma.

Exp Ther Med. 2018 Oct;16(4):3668-3673. (IF 1.785)

86. Yan ZC, He L, Qiu JH, Deng WT, Lu JR, Yuan Z, Liu DJ, Zheng RQ, Jiang W

LncRNA HOTAIR participates in the development and progression of adrenocortical carcinoma via regulating cell cycle.

EUR REV MED PHARMACO. 2018 Oct;22(20):6640-6649. (IF 3.024)

87. Zhou F, Zhang Y, Chen J, Hu Y, Xu Y

Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.

FRONT ENDOCRINOL. 2018 Oct 31;9:640. (IF 3.644)

88. Zhong L, Sun S, Yao S, Han X, Gu M, Shi J.

Histone deacetylase 5 promotes the proliferation and invasion of lung cancer cells.

Oncol Rep. 2018 Oct;40(4):2224-2232. (IF 3.417)

89. Zhang S, Wang YN, Wang L, Tsang YF, Li H, Fu X

Role of electron donor in CO2 fixation of chemoautotrophic bacteria and its preconditions: Verification in Alcaligenes hydrogenophilus.

ENZYME MICROB TECH. 2018 Nov;118:37-43. (IF 3.448)

90. Qin WW, Xin ZL, Wang HQ, Wang KP, Li XY, Wang X

Inhibiting lncRNA ROR suppresses growth, migration and angiogenesis in microvascular endothelial cells by up-regulating miR-26.

EUR REV MED PHARMACO. 2018 Nov;22(22):7985-7993. (IF 3.024)

91. Li S, He J

Pilose antler polypeptide protects against sevoflurane‑mediated neurocyte injury.

Mol Med Rep. 2018 Dec;18(6):5353-5360. (IF 2.1)

92. Qiao X, Lv SX, Qiao Y, Li QP, Ye B, Wang CC, Miao L

Long noncoding RNA ABHD11-AS1 predicts the prognosis of pancreatic cancer patients and serves as a promoter by activating the PI3K-AKT pathway.

EUR REV MED PHARMACO. 2018 Dec;22(24):8630-8639. (IF 3.024)

93. Xu XY, Wang Z, Ren S, Leng J, Hu JN, Liu Z, Chen C, Li W

Improved protective effects of American ginseng berry against acetaminophen-induced liver toxicity through TNF-α-mediated caspase-3/-8/-9 signaling pathways.

Phytomedicine. 2018 Dec 1;51:128-138. (IF 4.268)

94. He B, Geng S, Zhou W, Rui Y, Mu X, Zhang C, You Q, Su X

MMI-0100 ameliorates lung inflammation in a mouse model of acute respiratory distress syndrome by reducing endothelial expression of ICAM-1.

DRUG DES DEV THER. 2018 Dec 13;12:4253-4260. (IF 3.216)

95. Huang X, Gao Y, Qin J, Lu S

miR-214 Down-Regulation Promoted Hypoxia/Reoxygenation-Induced Hepatocyte Apoptosis Through TRAF1/ASK1/JNK Pathway.

DIGEST DIS SCI. 2018 Dec 17. (IF 2.751)

96. Zhang C, Wang Y

Metformin attenuates cells stemness and epithelial‑mesenchymal transition in colorectal cancer cells by inhibiting the Wnt3a/β‑catenin pathway.

Mol Med Rep. 2019 Feb;19(2):1203-1209. (IF 2.1)

97. Shen X, Zhang J, Zhang X, Wang Y, Hu Y, Guo J

Retinoic Acid-Induced Protein 14 (RAI14) Promotes mTOR-Mediated Inflammation Under Inflammatory Stress and Chemical Hypoxia in a U87 Glioblastoma Cell Line.

Cell Mol Neurobiol. 2019 Mar;39(2):241-254. (IF 3.606)

98. Zhang J, Tao X, Sun M, Ying R, Su W, Wei W, Meng X

A Rat Model of Radiation Vasculitis for the Study of Mesenchymal Stem Cell-Based Therapy.

Biomed Res Int. 2019 Mar 6;2019:3727635. (IF 2.276)

99. Zhang C, Li J, Qiu X, Chen Y, Zhang X

SUMO protease SENP1 acts as a ceRNA for TGFBR2 and thus activates TGFBR2/Smad signaling responsible for LPS-induced sepsis.

Biomed Pharmacother. 2019 Apr;112:108620. (IF 4.545)

100. Ma F, Li Z, Cao J, Kong X, Gong G

A TGFBR2/SMAD2/DNMT1/miR-145 negative regulatory loop is responsible for LPS-induced sepsis.

Biomed Pharmacother. 2019 Apr;112:108626. (IF 4.545)

101. Jiang Y, Gong Y, Lin N, Qiu W

Expression of miR-181a and TGF-β2 in lens epithelial cells of patients with cataractous retinal detachment and its clinical significance.

Exp Ther Med. 2019 Jun;17(6):4435-4440. (IF 1.785)

102. Gu Y, Zhang J, Zhang X, Liang G, Xu T, Niu W

Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro.

Tissue Eng Regen Med. 2019 Jun 17;16(4):415-429. (IF 2.374)

103. Zhuang L, Qu H, Cong J, Dai H, Liu X

MiR-181c affects estrogen-dependent endometrial carcinoma cell growth by targeting PTEN.

Endocr J. 2019 Jun 28;66(6):523-533. (IF 1.952)

104. Zheng Z, Wu M, Zhang J, Fu W, Xu N, Lao Y, Lin L, Xu H

The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45α.

Front Oncol. 2019 Jul 17;9:654. (IF 4.848)

105. Su J, Wang J, Luo J, Li H

Ultrasound-mediated destruction of vascular endothelial growth factor (VEGF) targeted and paclitaxel loaded microbubbles for inhibition of human breast cancer cell MCF-7 proliferation.

MOL CELL PROBE. 2019 Aug;46:101415. (IF 1.951)

106. Wei X, Gu X, Ma M, Lou C

Long noncoding RNA HCP5 suppresses skin cutaneous melanoma development by regulating RARRES3 gene expression via sponging miR-12.

ONCOTARGETS THER. 2019 Aug 12;12:6323-6335. (IF 3.337)

107. Deng S, Yang C, Nie K, Fan S, Zhu M, Zhu J, Chen Y, Yuan J, Zhang J, Xu H, Tian S, Chen J, Zhao M

Host cell protein PSMB10 interacts with viral NS3 protein and inhibits the growth of classical swine fever virus.

Virology. 2019 Nov;537:74-83. (IF 2.819)

108. Hui Liu, Yang Jiang, Hui Guan, Feng Li, Dongxiao Sun-Waterhouse, Yilun Chen, Dapeng Li

Enhancing the antioxidative effects of foods containing rutin and α-amino acids via the Maillard reaction: A model study focusing on rutin-lysine system

J Food Biochem. 2020 Jan;44(1):e13086.;doi: 10.1111/jfbc.13086. (IF 1.662)

109. Huiping Li, Fangfang Liu, Wenjing Qin

Circ_0072083 interference enhances growth-inhibiting effects of cisplatin in non-small-cell lung cancer cells via miR-545-3p/CBLL1 axis

Cancer Cell Int. 2020 Mar 12;20:78.;doi: 10.1186/s12935-020-1162-x. (IF 4.175)

110. Yang Wu, Yan Li, Liangqing Zheng, Pengcheng Wang, Yan Liu, Yongning Wu, ZhiYong Gong

The neurotoxicity of Nε-(carboxymethyl)lysine in food processing by a study based on animal and organotypic cell culture

ECOTOX ENVIRON SAFE. 2020 Mar 1;190:110077.;doi: 10.1016/j.ecoenv.2019.110077. (IF 4.872)

111. Wei Chen, Zhixian Yu, Weiping Huang, Yu Yang, Feng Wang, Hang Huang

LncRNA LINC00665 Promotes Prostate Cancer Progression via miR-1224-5p/SND1 Axis

ONCOTARGETS THER. 2020 Mar 26;13:2527-2535.;doi: 10.2147/OTT.S241578. (IF 3.337)

112. Yang Liu, Yiling Ding, Yanting Nie, Mengyuan Yang

EMP1 Promotes the Proliferation and Invasion of Ovarian Cancer Cells Through Activating the MAPK Pathway

ONCOTARGETS THER. 2020 Mar 9;13:2047-2055.;doi: 10.2147/OTT.S240028. (IF 3.337)

113. Hui Wang, Yanjun Jia, Jiamou Li, Qingsong Liu

Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro

Mol Med Rep. 2020 Mar;21(3):1640-1646.;doi: 10.3892/mmr.2020.10960. (IF 2.1)

114. Qiang Zhang, Yan Zhang, Meijun Yan, Kai Zhu, Qihang Su, Jie Pan, Mingjie Yang, Dong Zhou, Jun Tan

βig-h3 enhances chondrogenesis via promoting mesenchymal condensation in rat Achilles tendon heterotopic ossification model

AGING-US. 2020 Apr 20;12(8):7030-7041.;doi: 10.18632/aging.103060. (IF 4.831)

115. Xinna Du, Xuan Shen, Li Dai, Fangjie Bi, Hu Zhang, Chunfeng Lu

PSMD12 promotes breast cancer growth via inhibiting the expression of pro-apoptotic genes

BIOCHEM BIOPH RES CO. 2020 May 28;526(2):368-374.;doi: 10.1016/j.bbrc.2020.03.095. (IF 2.985)

116. Li Li, Qiaohua Zhang, Ke Lian

Circular RNA circ_0000284 plays an oncogenic role in the progression of non-small cell lung cancer through the miR-377-3p-mediated PD-L1 promotion

Cancer Cell Int. 2020 Jun 16;20:247.;doi: 10.1186/s12935-020-01310-y. (IF 4.175)

117. Danye Li, Caiyan Gao, Ling Zhao, Yongming Zhang

Inflammatory response is modulated by lincRNACox2 via the NF‑κB pathway in macrophages infected by Mycobacterium tuberculosis

Mol Med Rep. 2020 Jun;21(6):2513-2521.;doi: 10.3892/mmr.2020.11053. (IF 2.1)

118. Wei Chen, Daofeng Zheng, Tong Mou, Junliang Pu, Jiangwen Dai, Zuotian Huang, Yunhai Luo, Yuke Zhang, Zhongjun Wu

Tle1 attenuates hepatic ischemia/reperfusion injury by suppressing NOD2/NF-κB signaling

BIOSCI BIOTECH BIOCH. 2020 Jun;84(6):1176-1182.;doi: 10.1080/09168451.2020.1735928. (IF 1.516)

119. Lei Jiang, Cun Wang, Xinyue Shen

LncRNA GAS5 suppresses ER stress‑induced apoptosis and inflammation by regulating SERCA2b in HG‑treated retinal epithelial cell

Mol Med Rep. 2020 Aug;22(2):1072-1080.;doi: 10.3892/mmr.2020.11163. (IF 2.1)

120. Qunhu Zhang, Jie Li, You Li, Hui Che, Ying Chen, Jianghui Dong, Cory J Xian, Dengshun Miao, Liping Wang, Yongxin Ren

Bmi deficiency causes oxidative stress and intervertebral disc degeneration which can be alleviated by antioxidant treatment

J Cell Mol Med. 2020 Aug;24(16):8950-8961.;doi: 10.1111/jcmm.15528. (IF 4.486)

121. Wei Wang, Zhen-Hui Guo

Downregulation of lncRNA NEAT1 Ameliorates LPS-Induced Inflammatory Responses by Promoting Macrophage M2 Polarization via miR-125a-5p/TRAF6/TAK1 Axis

Inflammation. 2020 Aug;43(4):1548-1560.;doi: 10.1007/s10753-020-01231-y. (IF 3.212)

122. Qihai Sui, Jiaqi Liang, Zhengyang Hu, Zhencong Chen, Guoshu Bi, Yiwei Huang, Ming Li, Cheng Zhan, Zongwu Lin, Qun Wang

Genetic and microenvironmental differences in non-smoking lung adenocarcinoma patients compared with smoking patients

Transl Lung Cancer Res. 2020 Aug;9(4):1407-1421.;doi: 10.21037/tlcr-20-276.

123. Xiulong Ma, Zhongwei Wang, Hongtao Ren, Xing Bao, Yang Zhang, Baofeng Wang, Dongli Ruan

Long Non-Coding RNA GAS5 Suppresses Tumor Progression and Enhances the Radiosensitivity of Prostate Cancer Through the miR-320a/RAB21 Axis

Cancer Manag Res. 2020 Sep 22;12:8833-8845.;doi: 10.2147/CMAR.S244123. (IF 2.886)

124. Yu Liu, Wenzhi Shen, Qi Chen, Qingxin Cao, Wencheng Di, Rongfang Lan, Zheng Chen, Jian Bai, Zhonglin Han, Wei Xu

Inhibition of RAGE by FPS-ZM1 alleviates renal injury in spontaneously hypertensive rats

Eur J Pharmacol. 2020 Sep 5;882:173228.;doi: 10.1016/j.ejphar.2020.173228. (IF 3.263)

125. Rui Yu, Jie Yao, Yu Ren

A novel circRNA, circNUP98, a potential biomarker, acted as an oncogene via the miR-567/ PRDX3 axis in renal cell carcinoma

J Cell Mol Med. 2020 Sep;24(17):10177-10188.;doi: 10.1111/jcmm.15629. (IF 4.486)

126. Furong Song, Jun Liu, Yawei Feng, Yi Jin

Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458

Int J Mol Med. 2020 Sep;46(3):1135-1145.;doi: 10.3892/ijmm.2020.4667. (IF 3.098)

127. Wenjie Zhang, Wei Hong

Upregulation of miR-519d-3p Inhibits Viability, Proliferation, and G1/S Cell Cycle Transition of Oral Squamous Cell Carcinoma Cells Through Targeting CCND1

CANCER BIOTHER RADIO. 2020 Oct 14.;doi: 10.1089/cbr.2020.3984. (IF 2.314)

128. Xinxia Luo, Junyang Zhou, Zhixiao Wang, Yun He, Li Yu, Shinan Ma, Shan Wang, Xiaoli Wang, Yahong Yuan, Dongsheng Li, Taixing Cui, Yan Ding

An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction

Life Sci. 2020 Oct 15;259:118199.;doi: 10.1016/j.lfs.2020.118199. (IF 3.647)

129. Xin Jiang, Dong Chen

LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2

AGING-US. 2020 Oct 20;12(20):20069-20084.;doi: 10.18632/aging.103391. (IF 4.831)

130. Zhenhua Du, Lei Wang, Yu Xia

Circ_0015756 promotes the progression of ovarian cancer by regulating miR-942-5p/CUL4B pathway

Cancer Cell Int. 2020 Nov 27;20(1):572.;doi: 10.1186/s12935-020-01666-1. (IF 4.175)

131. Shouchao Li, Sheng Zheng

Down-Regulation of Circ_0032833 Sensitizes Colorectal Cancer to 5-Fluorouracil and Oxaliplatin Partly Depending on the Regulation of miR-125-5p and MSI1

Cancer Manag Res. 2020 Nov 4;12:11257-11269.;doi: 10.2147/CMAR.S270123. (IF 2.886)

132. Si-Jia Huang, Jing Huang, Yun-Bo Yan, Jiao Qiu, Rui-Qiao Tan, Yu Liu, Qing Tian, Li Guan, Shuai-Shuai Niu, Yanxiang Zhang, Zhijiang Xi, Ying Xiang, Quan Gong

The renoprotective effect of curcumin against cisplatin-induced acute kidney injury in mice: involvement of miR-181a/PTEN axis

RENAL FAILURE. 2020 Nov;42(1):350-357.;doi: 10.1080/0886022X.2020.1751658. (IF 1.985)

133. Xiuxia Liu, Peifeng Zhao, Wang Ge

Knockdown of circular RNA circZNF652 remits LPS-induced inflammatory damage by regulating miR-181a

Biofactors. 2020 Nov;46(6):1031-1040.;doi: 10.1002/biof.1606. (IF 4.734)

134. Zimeng Li, Yuanyu Lian, Riming Wei, Ling Jin, Houkang Cao, Tanglian Zhao, Xiaohui Ma, Mingli Zhong, Ya Gao, Kefeng Zhang

Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways

Life Sci. 2020 Dec 1;262:118546.;doi: 10.1016/j.lfs.2020.118546. (IF 3.647)

135. Liandong Xi, Lin Ruan, Xiaoguang Yao, Dong Zhang, Hongwei Yuan, Qiang Li, Cuihuan Yan

SIRT1 promotes pulmonary artery endothelial cell proliferation by targeting the Akt signaling pathway

Exp Ther Med. 2020 Dec;20(6):179.;doi: 10.3892/etm.2020.9309. (IF 1.785)

136. Xiaoquan Li, Jingxin Mo, Jun Li, Yalin Chen

lncRNA CASC2 inhibits lipopolysaccharide‑induced acute lung injury via miR‑27b/TAB2 axis

Mol Med Rep. 2020 Dec;22(6):5181-5190.;doi: 10.3892/mmr.2020.11606. (IF 2.1)

137. Han Xie, Yuan-Mei Gao, Yong-Chang Zhang, Ming-Wang Jia, Fang Peng, Qing-He Meng, Yi-Chun Wang

Low let-7d exosomes from pulmonary vascular endothelial cells drive lung pericyte fibrosis through the TGFβRI/FoxM1/Smad/β-catenin pathway

J Cell Mol Med. 2020 Dec;24(23):13913-13926.;doi: 10.1111/jcmm.15989. (IF 4.486)

138. Simin Luo, Qiping Shi, Wuji Li, Wenrui Wu, Zhengang Zha

ITGB1 promotes the chondrogenic differentiation of human adipose-derived mesenchymal stem cells by activating the ERK signaling

J Mol Histol. 2020 Dec;51(6):729-739.;doi: 10.1007/s10735-020-09918-0. (IF 2.531)

139. Jun Dong, Tingkai Fu, Yunxue Yang, Zhenxin Mu, Xingang Li

Long Noncoding RNA SNHG1 Promotes Lipopolysaccharide-Induced Activation and Inflammation in Microglia via Targeting miR-181b

Neuroimmunomodulation. 2021;28(4):255-265.;doi: 10.1159/000514549. (IF 1.685)

140. Hua Fang, Miao Yang, Qin Pan, Hon-Ling Jin, Hua-Feng Li, Ru-Rong Wang, Quan-Yun Wang, Jian-Ping Zhang

MicroRNA-22-3p alleviates spinal cord ischemia/reperfusion injury by modulating M2 macrophage polarization via IRF5

J Neurochem. 2021 Jan;156(1):106-120.;doi: 10.1111/jnc.15042. (IF 4.066)

141. Junli Liu, Jun Zhang, Yan Hu, Hongyan Zou, Xiuzhen Zhang, Xiaojun Hu

Inhibition of lncRNA DCST1-AS1 suppresses proliferation, migration and invasion of cervical cancer cells by increasing miR-874-3p expression

J Gene Med. 2021 Jan;23(1):e3281.;doi: 10.1002/jgm.3281. (IF 3.258)

142. Liangping Zhao, Li Wang, Daimin Zhang, Yuqi Chen, Fulu Jin

Puerarin alleviates coronary heart disease via suppressing inflammation in a rat model

Gene. 2021 Mar 1;771:145354.;doi: 10.1016/j.gene.2020.145354. (IF 2.984)

143. Danling Chen, LinLi Xu, Jinhua Wu, Haiying Liang, Yuemei Liang, Guocheng Liu

Downregulating miR-96-5p promotes proliferation, migration, and invasion, and inhibits apoptosis in human trophoblast cells via targeting DDAH1

Reprod Biol. 2021 Mar;21(1):100474.;doi: 10.1016/j.repbio.2020.100474. (IF 1.862)

144. Limin Ma, Hua Li, Yanmin Lin, Geng Wang, Qiangzhou Xu, Yuping Chen, Ke Xiao, Xuguang Rao

CircDUSP16 Contributes to Cell Development in Esophageal Squamous Cell Carcinoma by Regulating miR-497-5p/TKTL1 Axis

J Surg Res. 2021 Apr;260:64-75.;doi: 10.1016/j.jss.2020.11.052. (IF 1.841)

145. Qiang Wang, Guopan Yu, Han He, Zhongxin Zheng, Xuan Li, Ren Lin, Dan Xu

Differential expression of circular RNAs in bone marrow-derived exosomes from essential thrombocythemia patients

Cell Biol Int. 2021 Apr;45(4):869-881.;doi: 10.1002/cbin.11534. (IF 2.571)

146. Chuanbao Lin, Pengfei Qian, Yan Zhang, Zhihui Liu, Kun Dai, Dawei Sun

Plac1 promotes nasopharyngeal carcinoma cells proliferation, migration and invasion via Furin/NICD/PTEN pathway

Tissue Cell. 2021 Apr;69:101480.;doi: 10.1016/j.tice.2020.101480. (IF 1.837)

147. Guohua Gong, Jikai She, Danni Fu, Dong Zhen, Bin Zhang

Circular RNA circ_0084927 regulates proliferation, apoptosis, and invasion of breast cancer cells via miR-142-3p/ERC1 pathway

Am J Transl Res. 2021 May 15;13(5):4120-4136.; (IF 3.375)

148. Xingtao Ge, Gang Zhou

Protective effects of naringin on glucocorticoid-induced osteoporosis through regulating the PI3K/Akt/mTOR signaling pathway

Am J Transl Res. 2021 Jun 15;13(6):6330-6341.; (IF 3.375)

149. Jun He, Jing Yang, Tulan Shen, Jian He

Overexpression of long non-coding RNA XIST promotes IL-1β-induced degeneration of nucleus pulposus cells through targeting miR-499a-5p

Mol Cell Probes. 2021 Jun;57:101711.;doi: 10.1016/j.mcp.2021.101711.

150. Bei Wang, Dandan Chen, Haiying Hua

TBC1D3 family is a prognostic biomarker and correlates with immune infiltration in kidney renal clear cell carcinoma

Mol Ther Oncolytics. 2021 Jul 10;22:528-538.;doi: 10.1016/j.omto.2021.06.014.

151. Xue-Mei Zhang, Yang Sun, Ying-Lian Zhou, Zhuo-Min Jiao, Dan Yang, Yuan-Jiao Ouyang, Mei-Yu Yu, Jin-Yue Li, Wei Li, Duo Wang, Hui Yue, Jin Fu

Therapeutic effects of dental pulp stem cells on vascular dementia in rat models

Neural Regen Res. 2021 Aug;16(8):1645-1651.;doi: 10.4103/1673-5374.303042. (IF 3.171)

152. Zhiwei Yang, Guoyin Li, Yizhen Zhao, Lei Zhang, Xiaohui Yuan, Lingjie Meng, Huadong Liu, Yong Han, Lintao Jia, Shengli Zhang

Molecular Insights into the Recruiting Between UCP2 and DDX5/UBAP2L in the Metabolic Plasticity of Non-Small-Cell Lung Cancer

J Chem Inf Model. 2021 Aug 23;61(8):3978-3987.;doi: 10.1021/acs.jcim.1c00138. (IF 4.549)

153. Defang Ren, Yu Fu, Li Wang, Jianqin Liu, Xia Zhong, Jiyuan Yuan, Chaoli Jiang, Honglian Wang, Zhi Li

Tetrandrine ameliorated Alzheimer's disease through suppressing microglial inflammatory activation and neurotoxicity in the 5XFAD mouse

Phytomedicine. 2021 Sep;90:153627.;doi: 10.1016/j.phymed.2021.153627. (IF 4.268)

154. Han Zhao, Lingyan Feng, Wei Zhong, Hongyan Zhen, Qingjia Chi, Xiang Wang

Hyperphosphorylation of Tau Due to the Interference of Protein Phosphatase Methylesterase-1 Overexpression by MiR-125b-5p in Melatonin Receptor Knockout Mice

Int J Mol Sci. 2021 Oct 31;22(21):11850.;doi: 10.3390/ijms222111850. (IF 4.556)

155. Yinsha Miao, Xiaodong Chen, Mengting Qin, Wen Zhou, Yang Wang, Yanhong Ji

lncRNA GAS5, as a ceRNA, inhibits the proliferation of diffuse large B‑cell lymphoma cells by regulating the miR‑18a‑5p/RUNX1 axis

Int J Oncol. 2021 Nov;59(5):94.;doi: 10.3892/ijo.2021.5274. (IF 3.899)

156. Xin Wang, Wenting Zhang, Jingtao Na, Yanping Huo, Yacheng Wang, Ketong Liu

Spironolactone Inhibits Cardiomyocyte Hypertrophy by Regulating the Ca2+/Calcineurin/p-NFATc3 Pathway

J Healthc Eng. 2021 Dec 16;2021:3843830.;doi: 10.1155/2021/3843830. (IF 1.803)

157. Wenting Zhang, Xin Wang, Jing Li, Mingyuan Xu, Xiaolu Ren, Huiying Liu, Lu Xu, Jun Shao

Astragaloside IV Reduces OxLDL-Induced BNP Overexpression by Regulating HDAC

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