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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2021-25mg | 黄芩苷(98%, HPLC) | 25mg | 60.00元 |
| SM2021-10mM | 黄芩苷(98%, HPLC) | 10mM×0.2ml | 73.00元 |
| SM2021-100mg | 黄芩苷(98%, HPLC) | 100mg | 204.00元 |
| 中文名 | 黄芩苷 |
| 英文名 | Baicalin |
| 中文别名 | - |
| 英文别名 | Baicalein 7-beta-D-glucuronide; Baicaloside; Baicalein 7-O-β-D-glucuronide |
| 来源 | 黄芩Scutellaria baicalensis Georgi |
| 化合物类型 | 黄酮类(Flavonoids)>黄酮 |
| 化学式 | C21H18O11 |
| 分子量 | 446.36 |
| CAS号 | 21967-41-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
DMSO: ≥ 100 mg/ml (224.03 mM); Water: < 0.1 mg/ml (insoluble) |
| 溶液配制 | 5mg加入1.12ml DMSO，或者每4.46mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Baicalin is a flavonoid glycoside isolated from Scutellaria baicalensis. Baicalin reduces the expression of NF-κB. | ||||
| 信号通路 | Autophagy | ||||
| 靶点 | TLR2/4 | MyD88 | p-NF-κB | p-IκB | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Baicalin protects against ischemia-reperfusion injury (IRI) by altering the production of various mediators, including reactive oxygen species (ROS), Toll-like receptor (TLR)2 and TLR4, NF-κB, Bax, and Bcl-2. Baicalin treatment inhibits the increased expression of the proinflammatory cytokines TLR2/4, MyD88, p-NF-κB, and p- IκB, as well as increase the expression of IκB protein, an NF-κB inhibitor, with the degree of inhibition positively related to the dosage of Baicalin. Cell viability is determined by MTT assay. Compared with control cells, cell viability is significantly decreased in SH-SY5Y cells treated with thrombin. Pre-treatment with Baicalin (5, 10, 20 μM) increases cell viability in a dose-dependent manner compared with cells treated thrombin alone. | ||||
| 体内研究 | Baicalin pretreatment dose-dependently protects against a loss of renal function, with the two higher doses (10 and 100 mg/kg) significantly decreasing Scr and blood urea nitrogen (BUN) concentrations. Tissue injury, as assessed using a 0-3 point scoring system, is lower for the Baicalin treated groups than for the ischemia-reperfusion (IR)+saline group. Compared with the sham group, malondialdehyde (MDA) content is only slightly up-regulated and the SOD activity is only slightly down-regulated in rats treated with 10 and 100 mg/kg Baicalin, indicating that Baicalin abrogates the increase in oxidative stress following reperfusion. | ||||
| 临床实验 | N/A | ||||
1.Lin M, et al. BMC Complement Altern Med. 2014,14:19.
2.Ju XN, et al. Int J Clin Exp Pathol. 2015,8(11):14021-7.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2021-10mM | 黄芩苷(98%, HPLC) | 10mM×0.2ml |
| SM2021-25mg | 黄芩苷(98%, HPLC) | 25mg |
| SM2021-100mg | 黄芩苷(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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