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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2017-10mM | 白杨素(98%, HPLC) | 10mM×0.2ml | 77.00元 |
| SM2017-25mg | 白杨素(98%, HPLC) | 25mg | 180.00元 |
| SM2017-100mg | 白杨素(98%, HPLC) | 100mg | 612.00元 |
| 中文名 | 白杨素 |
| 英文名 | Chrysin |
| 中文别名 | 柯因；5,7-二羟黄酮 |
| 英文别名 | 5,7-Dihydroxyflavone; Chrysinic acid |
| 来源 | 意大利蜂Apis mellifera L.；木蝴蝶Oroxylum indicum (Linn.) Kurz |
| 化合物类型 | 黄酮类(Flavonoids)>黄酮 |
| 化学式 | C15H10O4 |
| 分子量 | 254.24 |
| CAS号 | 480-40-0 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 100 mg/ml (393.33 mM) |
| 溶液配制 | 5mg加入1.97ml DMSO，或者每2.54mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Chrysin is one of the most well known estrogen blockers. | ||||
| 信号通路 | PI3K/AKT; MAPK | ||||
| 靶点 | Estrogen Receptor | NF-κB | - | - | - |
| IC50 | Wnt | - | - | - | - |
| 体外研究 | Chrysin is mainly found in passion flowers, honey, and propolis acts as a potential therapeutic and preventive agent to inhibit proliferation and invasion of various human cancer cells. Although Chrysin has anti-carcinogenic effects in several cancers, little is known about its functional roles in ovarian cancer which shows poor prognosis and chemoresistance to traditional therapeutic agents. Chrysin inhibits ovarian cancer cell proliferation and induced cell death by increasing reactive oxygen species (ROS) production and cytoplasmic Ca2+ levels as well as inducing loss of mitochondrial membrane potential (MMP). Chrysin activates MAPK and PI3K/AKT pathways in ES2 and OV90 cells in concentration-response experiments. Chrysin suppresses tumor growth byregulating canonical Wnt and nuclear factor NF-κB signaling cascades cancer cells. Chrysin stimulates the phosphorylation of AKT and P70S6K proteins in both ES2 and OV90 cells compared tothe untreated control cells. In addition, Chrysin activates the phospho-ERK1/2, p38,and JNK proteins as members of the MAPK pathway in the ovarian cancer cells. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
1.Lim W, et al. J Cell Physiol. 2018,233(4):3129-3140.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2017-10mM | 白杨素(98%, HPLC) | 10mM×0.2ml |
| SM2017-25mg | 白杨素(98%, HPLC) | 25mg |
| SM2017-100mg | 白杨素(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
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