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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM6028-10mM | 23-乙酰泽泻醇B (98%, HPLC) | 10mM×0.2ml | 159.00元 |
| SM6028-5mg | 23-乙酰泽泻醇B (98%, HPLC) | 5mg | 173.00元 |
| SM6028-25mg | 23-乙酰泽泻醇B (98%, HPLC) | 25mg | 720.00元 |
| SM6028-100mg | 23-乙酰泽泻醇B (98%, HPLC) | 100mg | 2448.00元 |
化学信息：
| 中文名 | 23-乙酰泽泻醇B |
| 英文名 | Alisol B 23-acetate |
| 中文别名 | 泽泻醇B-23-乙酸酯；泽泻醇B醋酸酯 |
| 英文别名 | 23-Acetylalismol B; 23-O-Acetylalisol B; Alisol B monoacetate; Alisol B,23-acetate; Alisol B Acetate |
| 来源 | 泽泻Alisma plantago-aquatica Linn. |
| 化合物类型 | 萜类(Terpenoids)>三萜>达玛烷型四环三萜 |
| 化学式 | C32H50O5 |
| 分子量 | 514.74 |
| CAS号 | 26575-95-1 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 50 mg/ml (97.14 mM); Water: < 0.1 mg/ml (insoluble) |
| 溶液配制 | 10mg加入1.94ml DMSO，或者每5.15mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Alisol B 23-acetate (23-Acetylalismol B), a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation. | ||||
| 信号通路 | FXR; Anti-hepatotoxic | ||||
| 靶点 | - | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Alisol-B 23-acetate has an effect on FXR activation in a dose-dependent manner using luciferase reporter assay in HepG2 cells. | ||||
| 体内研究 | In alisol B 23-acetate-treated mice, the changes in transporters and enzymes, as well as ameliorative liver histology were abrogated by FXR antagonist guggulsterone. Alisol B 23-acetate treatment in a dose-dependent manner resulted in protection against hepatotoxicity induced by CCl4via FXR activation. Through FXR activation, alisol B 23-acetate promoted hepatocyte proliferation via an induction in hepatic levels of FoxM1b, Cyclin D1 and Cyclin B1. Alisol B 23-acetate also reduced hepatic bile acids through a decrease in hepatic uptake transporter Ntcp, bile acid synthetic enzymes Cyp7a1, Cyp8b1, and an increase in efflux transporter Bsep, Mrp2 expression. In addition, alisol B 23-acetate induced the expression of STAT3 phosphorylation, and STAT3 target genes Bcl-xl and SOCS3, resulting in decreased hepatocyte apoptosis. | ||||
| 临床实验 | N/A | ||||
1. Meng Q, et al. Food Funct. 2015,6(4):1241-50.
2. Meng Q, et al. Toxicol Appl Pharmacol. 2015,283(3):178-86.
3. Meng Q, et al. Biochem Pharmacol. 2014,92(2):289-98.
4. Meng Q, et al. Pharm Res. 2015,32(11):3688-98.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM6028-10mM | 23-乙酰泽泻醇B (98%, HPLC) | 10mM×0.2ml |
| SM6028-5mg | 23-乙酰泽泻醇B (98%, HPLC) | 5mg |
| SM6028-25mg | 23-乙酰泽泻醇B (98%, HPLC) | 25mg |
| SM6028-100mg | 23-乙酰泽泻醇B (98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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