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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM5012-10mM | 款冬酮(98%, HPLC) | 10mM×0.2ml | 139.00元 |
| SM5012-5mg | 款冬酮(98%, HPLC) | 5mg | 180.00元 |
| SM5012-25mg | 款冬酮(98%, HPLC) | 25mg | 750.00元 |
| SM5012-100mg | 款冬酮(98%, HPLC) | 100mg | 2550.00元 |
化学信息：
| 中文名 | 款冬酮 |
| 英文名 | Tussilagone |
| 中文别名 | - |
| 英文别名 | Farfaratin |
| 来源 | 款冬Tussilago farfara L. |
| 化合物类型 | 萜类(Terpenoids)>倍半萜 |
| 化学式 | C23H34O5 |
| 分子量 | 390.51 |
| CAS号 | 104012-37-5 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 62.5 mg/ml (160.05 mM) |
| 溶液配制 | 5mg加入1.28ml DMSO，或者每3.91mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice. | ||||
| 信号通路 | Inflammation | ||||
| 靶点 | NO | NF-κB | TNF-α | HMGB1 | PGE2 |
| IC50 | - | - | - | - | - |
| 体外研究 | Tussilagone suppressed the expression of the inflammatory mediators, nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1), in lipopolysaccharide-stimulated RAW 264.7 cells and peritoneal macrophages. Tussilagone also reduced the activation of the mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) involved in the activation of various inflammatory mediators in activated macrophages. | ||||
| 体内研究 | Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration. | ||||
| 临床实验 | N/A | ||||
1. Cheon HJ, et al. Chem Biol Interact. 2018,294:74-80.
2. Kim YK, et al. Int J Mol Sci. 2017,18(12):2744.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM5012-10mM | 款冬酮(98%, HPLC) | 10mM×0.2ml |
| SM5012-5mg | 款冬酮(98%, HPLC) | 5mg |
| SM5012-25mg | 款冬酮(98%, HPLC) | 25mg |
| SM5012-100mg | 款冬酮(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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