微信在线咨询
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM3029-5mg | 芦荟苷(98%, HPLC) | 5mg | 69.00元 |
| SM3029-10mM | 芦荟苷(98%, HPLC) | 10mM×0.2ml | 96.00元 |
| SM3029-25mg | 芦荟苷(98%, HPLC) | 25mg | 288.00元 |
| SM3029-100mg | 芦荟苷(98%, HPLC) | 100mg | 979.00元 |
化学信息：
| 中文名 | 芦荟苷 |
| 英文名 | Aloin |
| 中文别名 | 芦荟甙；芦荟素；巴白洛英；坝巴甙；芦荟素A；芦荟苷A |
| 英文别名 | Aloin A; Barbaloin A |
| 来源 | 芦荟Aloe vera（Haw.） Berg |
| 化合物类型 | 醌类(Quinones)>蒽醌>蒽酮 |
| 化学式 | C21H22O9 |
| 分子量 | 418.39 |
| CAS号 | 1415-73-2 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO : ≥ 27 mg/ml (64.53 mM) |
| 溶液配制 | 5mg加入1.20ml DMSO，或者每4.18mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Aloin(Aloin-A; Barbaloin-A) is a natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities. | ||||
| 信号通路 | - | ||||
| 靶点 | VEGFR2 | STAT3 | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Aloin significantly inhibited HUVECs proliferation, migration and tube formation in vitro. Aloin suppressed activation of VEGF receptor (VEGFR) 2 and STAT3 phosphorylation in endothelial cells. In addition, the constitutively activated STAT3 protein, and the expression of STAT3-regulated antiapoptotic (Bcl-xL), proliferative (c-Myc), and angiogenic (VEGF) proteins were also down-regulated in response to AL in human SW620 cancer cells. Aloin exerted inhibition of cell proliferation, adhesion and invasion abilities of B16-F10 melanoma cells under non-cytotoxic concentrations. Furthermore, aloin induced melanoma cell differentiation through the enhancement of melanogenesis and transglutaminase activity. | ||||
| 体内研究 | Aloin substantially reduced tumor volumes and weight in vivo mouse xenografts, without obviously toxicity. Aloin (10, 30 mg/kg bw) or vehicle was given by gavage to mice after each alcohol administration. Alcohol elevated the serum transaminases alanine aminotransferase, aspartate aminotransferase, total cholesterol and triglyceride levels which were significantly attenuated by the co-administration of aloin (p < 0.05). | ||||
| 临床实验 | N/A | ||||
1. Pan Q, et al. Cancer Cell Int. 2013,13(1):69.
2. Tabolacci C, et al. Amino Acids. 2013,44(1):293-300.
3. Cui Y, et al. Arch Pharm Res. 2014,37(12):1624-33.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM3029-10mM | 芦荟苷(98%, HPLC) | 10mM×0.2ml |
| SM3029-5mg | 芦荟苷(98%, HPLC) | 5mg |
| SM3029-25mg | 芦荟苷(98%, HPLC) | 25mg |
| SM3029-100mg | 芦荟苷(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
微信在线咨询
