产品编号 | 产品名称 | 产品包装 | 产品价格 |
SC0362-10mM | K252a (PKC抑制剂) | 10mM×0.2ml | 1050.00元 |
化学名 | (9S,10R,12R)-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG-3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID METHYL ESTER |
简称 | K252a |
别名 | K 252; K 252a; K 252b; K 252c; K 252d; K-252; K-252a; K-252b; K-252c; K-252d; staurosporine aglycone; staurosporinone |
中文名 | 诺卡氏菌液 |
化学式 | C27H21N3O5 |
分子量 | 467.47 |
CAS号 | 99533-80-9; 97161-97-2 |
纯度 | ≥98% |
溶剂/溶解度 | Water <1mg/ml; DMSO 20mg/ml; Ethanol <1mg/ml |
溶液配制 | SC0362-10mM用DMSO配制。 |
生物信息:
产品描述 | Originally isolated from the soil fungi Nocardiopisis sp., K252a is a staurosporine analog that inhibits various protein kinases through competition with the ATP binding site. K252a is a reversible cell-permeable, potent inhibitor of phosphorylase kinase (IC50=1.7nM), protein kinase A (PKA) (IC50=140nM), and protein kinase C (PKC) (IC50=470nM). K252a is also known to inhibit protein kinase G and CaM kinase II. K252a inhibits nerve growth factor induced Trk activation (IC50=3nM), as well as downstream signaling. K252a is reported to induce apoptosis and cell cycle arrest through cdc25 and cdc2 inhibition. | ||||
信号通路 | PKC Signaling | ||||
靶点 | PKA | PKC | phosphorylase kinase | - | - |
IC50 | 140nM | 470nM | 1.7nM | - | - |
体外研究 | N/A | ||||
体内研究 | N/A | ||||
临床实验 | N/A | ||||
特征 | N/A |
酶活性检测实验 | |
方法 | N/A |
细胞实验 | |
细胞系 | N/A |
浓度 | N/A |
处理时间 | N/A |
方法 | N/A |
动物实验 | |
动物模型 | N/A |
配制 | N/A |
剂量 | N/A |
给药方式 | N/A |
Kase, H. et al. J Antibiot (Tokyo). 1986, 39, 1059-65.
Kase, H. et al. Biochem Biophys Res Commun. 1987, 142, 436-40.
Elliott, L.H. et al. Biochem Biophys Res Commun. 1990, 171, 148-54.
Davis, P.D. et al. J Med Chem. 1992, 35, 177-84.
Koizumi, S. et al. J Neurosci. 1988, 8, 715-21.
Hashimoto, Y. et al. Biochem Biophys Res Commun. 1991, 181, 423-9.
Berg, M.M. et al. J Biol Chem. 1992, 267, 13-6.
Tapley, P. et al. Oncogene. 1992, 7, 371-81.
Chin, L.S. et al. Cancer Invest. 1999, 17, 391-5.
包装清单:
产品编号 | 产品名称 | 包装 |
SC0362-10mM | K252a (PKC抑制剂) | 10mM×0.2ml |
— | 说明书 | 1份 |
-20℃保存,至少一年有效。
注意事项:本产品可能对人体有一定的毒害作用,请注意适当防护,以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。