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 线粒体膜电位检测试剂盒(JC-1)

  产品编号C2006
  产品包装: >100次
  产品价格: 909.00元
产品编号 产品名称 产品包装 产品价格
C2006 线粒体膜电位检测试剂盒(JC-1) >100次 909.00元

      线粒体膜电位检测试剂盒(JC-1)(Mitochondrial membrane potential assay kit with JC-1)是一种以JC-1为荧光探针,快速灵敏地检测细胞、组织或纯化的线粒体膜电位变化的试剂盒,可以用于早期的细胞凋亡检测。
      JC-1是一种广泛用于检测线粒体膜电位(mitochondrial membrane potential)△Ψm的理想荧光探针。可以检测细胞、组织或纯化的线粒体膜电位。在线粒体膜电位较高时,JC-1聚集在线粒体的基质(matrix)中,形成聚合物(J-aggregates),可以产生红色荧光;在线粒体膜电位较低时,JC-1不能聚集在线粒体的基质中,此时JC-1为单体(monomer),可以产生绿色荧光。这样就可以非常方便地通过荧光颜色的转变来检测线粒体膜电位的变化。常用红绿荧光的相对比例来衡量线粒体去极化的比例。
      线粒体膜电位的下降是细胞凋亡早期的一个标志性事件。通过JC-1从红色荧光到绿色荧光的转变可以很容易地检测到细胞膜电位的下降,同时也可以用JC-1从红色荧光到绿色荧光的转变作为细胞凋亡早期的一个检测指标。
      JC-1单体的最大激发波长为514nm,最大发射波长为529nm;JC-1聚合物(J-aggregates)的最大激发波长为585nm,最大发射波长为590nm。实际观察时,使用常规的观察红色荧光和绿色荧光的设置即可。
      本试剂盒提供了CCCP作为诱导线粒体膜电位下降的阳性对照。
      对于六孔板中的样品,本试剂盒共可以检测100个样品;对于12孔中的样品,本试剂盒共可以检测200个样品。
包装清单:

产品编号 产品名称 包装
C2006-1 JC-1(200X) 100μl/管,共5管
C2006-2 超纯水 90ml
C2006-3 JC-1染色缓冲液(5X) 80ml
C2006-4 CCCP(10mM) 20μl
说明书 1份

保存条件:
      -20℃保存。JC-1(200X)需避光保存,并尽量避免反复冻融。超纯水和JC-1染色缓冲液(5X)也可4℃保存。
注意事项:
      JC-1(200X)在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内,可以20-25℃水浴温育片刻至全部融解后使用。
      必须先把JC-1(200X)用试剂盒提供的超纯水充分溶解混匀后,才可以加入JC-1染色缓冲液(5X)。不可先配制JC-1染色缓冲液(1X)再加入JC-1(200X),这样JC-1会很难充分溶解,会严重影响后续的检测。
      装载完JC-1后用JC-1染色缓冲液(1X)洗涤时,使JC-1染色缓冲液(1X)保持4℃左右,此时的洗涤效果较好。
      JC-1探针装载完并洗涤后尽量在30分钟内完成后续检测。在检测前需冰浴保存。
      请勿把JC-1染色缓冲液(5X)全部配制成JC-1染色缓冲液(1X),本试剂盒使用过程中需直接使用JC-1染色缓冲液(5X)。
      如果发现JC-1染色缓冲液(5X)中有沉淀,必须全部溶解后才能使用,为促进溶解可以在37℃加热。
      CCCP为线粒体电子传递链抑制剂,对人体有害,操作时请小心,并注意有效防护以避免直接接触人体或吸入体内。
      本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
      为了您的安全和健康,请穿实验服并戴一次性手套操作

使用说明:
1. JC-1染色工作液的配制:
六孔板每孔所需JC-1染色工作液的量为1ml,其它培养器皿的JC-1染色工作液的用量以此类推;对于细胞悬液每50-100万细胞需0.5ml JC-1染色工作液。取适量JC-1(200X),按照每50微升JC-1(200X)加入8ml超纯水的比例稀释JC-1。剧烈Vortex充分溶解并混匀JC-1。然后再加入2ml JC-1染色缓冲液(5X),混匀后即为JC-1染色工作液。
2. 阳性对照的设置:
把试剂盒中提供的CCCP(10mM)推荐按照1:1000的比例加入到细胞培养液中,稀释至10μM,处理细胞20分钟。随后按照下述方法装载JC-1,进行线粒体膜电位的检测。对于大多数细胞,通常10μM CCCP处理20分钟后线粒体的膜电位会完全丧失,JC-1染色后观察应呈绿色荧光;而正常的细胞经JC-1染色后应显示红色荧光。对于特定的细胞,CCCP的作用浓度和作用时间可能有所不同,需自行参考相关文献资料确定。
3. 对于悬浮细胞:
a. 取10-60万细胞,重悬于0.5ml细胞培养液中,细胞培养液中可以含血清和酚红。
b. 加入0.5ml JC-1染色工作液,颠倒数次混匀。细胞培养箱中37℃孵育20分钟。
c. 在孵育期间,按照每1ml JC-1染色缓冲液(5X)加入4ml蒸馏水的比例,配制适量的JC-1染色缓冲液(1X),并放置于冰浴。
d. 37℃孵育结束后, 600g 4℃离心3-4分钟,沉淀细胞。弃上清,注意尽量不要吸除细胞。
e. 用JC-1染色缓冲液(1X)洗涤2次:加入1ml JC-1染色缓冲液(1X)重悬细胞,600g 4℃离心3-4分钟,沉淀细胞,弃上清。再加入1ml JC-1染色缓冲液(1X)重悬细胞,600g 4℃离心3-4分钟,沉淀细胞,弃上清。
f. 再用适量JC-1染色缓冲液(1X)重悬后,用荧光显微镜或激光共聚焦显微镜观察,也可以用荧光分光光度计检测或流式细胞仪分析。
4. 对于贴壁细胞:
注意:对于贴壁细胞,如果希望采用荧光分光光度计或流式细胞仪检测,可以先收集细胞,重悬后参考悬浮细胞的检测方法。
a. 对于六孔板的一个孔,吸除培养液,根据具体实验如有必要可以用PBS或其它适当溶液洗涤细胞一次,加入1ml细胞培养液。细胞培养液中可以含有血清和酚红。
b. 加入1ml JC-1染色工作液,充分混匀。细胞培养箱中37℃孵育20分钟。
c. 在孵育期间,按照每1ml JC-1染色缓冲液(5X)加入4ml蒸馏水的比例,配制适量的JC-1染色缓冲液(1X),并放置于冰浴。
d. 37℃孵育结束后, 吸除上清,用JC-1染色缓冲液(1X)洗涤2次。
e. 加入2ml细胞培养液,培养液中可以含有血清和酚红。
f. 荧光显微镜或激光共聚焦显微镜下观察。
5. 对于纯化的线粒体:
a. 把配制好的JC-1染色工作液再用JC-1染色缓冲液(1X)稀释5倍。
b. 0.9ml 5倍稀释的JC-1染色工作液中加入0.1ml总蛋白量为10-100微克纯化的线粒体。
c. 用荧光分光光度计或荧光酶标仪检测:混匀后直接用荧光分光光度计进行时间扫描(time scan),激发波长为485nm,发射波长为590nm。如果使用荧光酶标仪,激发波长不能设置为485nm时,可以在475-520nm范围内设置激发波长。另外,也可以参考下面步骤6中的波长设置进行荧光检测。
d. 用荧光显微镜或激光共聚焦显微镜观察:方法同下面的步骤6。
6. 荧光观测和结果分析:
检测JC-1单体时可以把激发光设置为490nm,发射光设置为530nm;检测JC-1聚合物时,可以把激发光设置为525nm,发射光设置为590nm。注意:此处测定荧光时不必把激发光和发射光设置在最大激发波长和最大发射波长。如使用荧光显微镜观察,检测JC-1单体时可以参考观察其它绿色荧光时的设置,如观察GFP或FITC时的设置;检测JC-1聚合物时可以参考观察其它红色荧光,如碘化丙啶或Cy3时的设置。出现绿色荧光说明线粒体膜电位下降,并且该细胞很可能处于细胞凋亡早期。出现红色荧光说明线粒体膜电位比较正常,细胞的状态也比较正常。
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使用本产品的文献:
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36.Zhang Y, Guo J, Zeng L, Zhang J, Hui Y, Liu J, Qing X, Sun X, Guo G.
Tert-butyl-2(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2-pyrrolidine-1-carboxylic ester displays novel cytotoxicity through reactive oxygen species-mediated oxidative damage in MCF-7 and MDA-MB-231 cells.
Chem Biol Interact. 2011 Jul 15;192(3):287-97.
37.Yang XX, Chen J, Zhou Q, Guo XY, Xiao P, Wu J, Xu JT.
Troglitazone induced apoptosis of human pterygium fibroblasts through a mitochondrial-dependent pathway.
Int J Ophthalmol. 2011;4(2):143-6.
38.Liu J, Xu X, Feng X, Zhang B, Wang J.
Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation andinduces the depolarization of mitochondria and apoptosis in glioma cells U251.
J Exp Clin Cancer Res. 2011 Sep 9;30:80.
39.Liu Q, Li Y, Hu L, Wang D.
Lycium barbarum Polysaccharides Attenuate Cisplatin-Induced Hair Cell Loss in Rat CochlearOrganotypic Cultures.
Int J Mol Sci. 2011;12(12):8982-92.
40.Cui M, Zhang Y, Liu S, Xie W, Ji M, Lou H, Li X.
1-oxoeudesm-11(13)-ene-12,8α-lactone-induced apoptosis via ROS generation and mitochondriaactivation in MCF-7 cells.
Arch Pharm Res. 2011 Aug;34(8):1323-9.
41.Zhang YH, Zhao CQ, Jiang LS, Dai LY.
Cyclic stretch-induced apoptosis in rat annulus fibrosus cells is mediated in part by endoplasmicreticulum stress through nitric oxide production.
Eur Spine J. 2011 Aug;20(8):1233-43.
42.Chen Y, Xie X.
Tacrolimus attenuates myocardium damage to the total hepatic ischemia-reperfusion viaregulation of the mitochondrial function.
J Surg Res. 2012 Jan;172(1):e47-54.
43.Yang X, Chen L, Liu Y, Yang Y, Chen T, Zheng W, Liu J, He QY.
Ruthenium methylimidazole complexes induced apoptosis in lung cancer A549 cells throughintrinsic mitochondrial pathway.
Biochimie. 2012 Feb;94(2):345-53.
44.Nie X, Song S, Zhang L, Qiu Z, Shi S, Liu Y, Yao L, Zhu D.
15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells fromapoptosis via inducible nitric oxide synthase (iNOS) pathway.
Prostaglandins Other Lipid Mediat. 2012 Jan;97(1-2):50-9.
45.Li C, Li C, Zhu X, Wang C, Liu Z, Li W, Lu C, Zhou X.
The expression and putative role of brain-derived neurotrophic factor and its receptor in bovinesperm.
Theriogenology. 2012 Feb;77(3):636-43.
46.Hua S, Lu C, Song Y, Li R, Liu X, Quan F, Wang Y, Liu J, Su F, Zhang Y.
High levels of mitochondrial heteroplasmy modify the development of ovine-bovine interspeciesnuclear transferred embryos.
Reprod Fertil Dev. 2012;24(3):501-9.
47.Li XX, He GR, Mu X, Xu B, Tian S, Yu X, Meng FR, Xuan ZH, Du GH.
Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolatedrat brain mitochondria.
Eur J Pharmacol. 2012 Jan 15;674(2-3):227-33.
48.Zhuang XJ, Huang Y, Duan YP, Zhang M, Lu YQ, Lu KH.
Translocation of active mitochondria during buffalo (Bubalus bubalis) oocytes in vitro maturation,fertilization and preimplantation embryo development.
Reprod Domest Anim. 2012 Jun;47(3):443-8.
49.Gu L, Liang X, Wang L, Yan Y, Ni Z, Dai H, Gao J, Mou S, Wang Q, Chen X, Wang L, Qian J.
Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes.
Kidney Int. 2012 Mar;81(5):458-68.
50.Ma J, Zhang L, Han W, Shen T, Ma C, Liu Y, Nie X, Liu M, Ran Y, Zhu D.
Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EETin pulmonary artery endothelial cells.
J Lipid Res. 2012 Jun;53(6):1093-105.
51.Wang SW, Wang YJ, Su YJ, Zhou WW, Yang SG, Zhang R, Zhao M, Li YN, Zhang ZP, Zhan DW, Liu RT.
Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress and decreasesthe production of nitric oxide and proinflammatory cytokines.
Neurotoxicology. 2012 Jun;33(3):482-90.
52.Zhu Y, Li YH, Hu RH, Zheng YN,Feng N, Chen F, Wang J, Li HY.
Origin of hydrogen peroxide during the cowpea-Xanthomonas interaction.
AUSTRALASIAN PLANT PATHOLOGY. 2012;41(1):1-11.
53.Ou XH, Li S, Wang ZB, Li M, Quan S, Xing F, Guo L, Chao SB, Chen Z, Liang XW, Hou Y, Schatten H, Sun QY.
Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouseoocytes.
Hum Reprod. 2012 Jul;27(7):2130-45.
54.Quan X, Wang Y, Ma X, Liang Y, Tian W, Ma Q, Jiang H, Zhao Y.
α-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1 cells via inhibiting fattyacid synthase.
PLoS One. 2012;7(3):e33376.
55.
Zhang L, Li K, Bing Ma L, Gong SB, Wang GY, Liu Y, Ji XY, Xu L, Liu SK, Chen P, Ouyang RY, Xiang XD.
Effects and mechanism of arsenic trioxide on reversing the asthma pathologies including Th17-IL-17 axis in amouse model.
Iran J Allergy Asthma Immunol. 2012 Jun;11(2):133-45.
56.Tao Q, Fan X, Li T, Tang Y, Yang D, Le W.
Gender segregation in gene expression and vulnerability to oxidative stress induced injury inventral mesencephalic cultures of dopamine neurons.
J Neurosci Res. 2012 Jan;90(1):167-78.
57.Ge H, Tollner TL, Hu Z, Dai M, Li X, Guan H, Shan D, Zhang X, Lv J, Huang C, Dong Q.
The importance of mitochondrial metabolic activity and mitochondrial DNA replication duringoocyte maturation in vitro on oocyte quality and subsequent embryo developmental competence.
Mol Reprod Dev. 2012 Jun;79(6):392-401.
58.Yu GR, Qin WW, Li JP, Hua W, Meng YL, Chen R, Yan B, Wang L, Zhang X, Jia LT, Zhao J, Zhang R, Yang AG.
HIV-TAT-fused FHIT protein functions as a potential pro-apoptotic molecule in hepatocellularcarcinoma cells.
Biosci Rep. 2012 Jun;32(3):271-9.
59.Shi ZY, Li YQ, Kang YH, Hu GQ, Huang-fu CS, Deng JB, Liu B.
Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of humanhepatocarcinoma SMMC-7721 cells.
Acta Pharmacol Sin. 2012 Feb;33(2):271-8.
60.Su Y, Wang X, Xu W, Xue L, He C, Yang D, An R.
Arsenic trioxide increases the sensitivity of 786-0 renal carcinoma cells to radiotherapy.
Cancer Invest. 2012 Feb;30(2):114-8.
61.Zhang HA, Gao M, Zhang L, Zhao Y, Shi LL, Chen BN, Wang YH, Wang SB, Du GH.
Salvianolic acid A protects human SH-SY5Y neuroblastoma cells against H2O2-induced injury by increasing stress tolerance ability.
Biochem Biophys Res Commun. 2012 May 11;421(3):479-83.
62.Shen X, Liu L, Yin F, Ma H, Zou S.
Effect of dehydroepiandrosterone on cell growth and mitochondrial function in TM-3 cells.
Gen Comp Endocrinol.2012 May 15;177(1):177-86.
63.Sang H, Zhang L, Li J.
Anti-benzopyrene-7,8-diol-9,10-epoxide induces apoptosis via mitochondrial pathway in humanbronchiolar epithelium cells independent of the mitochondria permeability transition pore.
Food Chem Toxicol. 2012 Jul;50(7):2417-23.
64.
Fu J, Dang Z, Deng Y, Lu G.
Regulation of c-Myc and Bcl-2 induced apoptosis of human bronchial epithelial cells by zinc oxide nanoparticles.
J Biomed Nanotechnol. 2012 Aug;8(4):669-75.
65.Zhang J, Song W, Guo J, Zhang J, Sun Z, Ding F, Gao M.
Toxic effect of different ZnO particles on mouse alveolar macrophages.
JHazard Mater. 2012 Jun 15;219-220:148-55.
66.Zhao P, Han T, Guo JJ, Zhu SL, Wang J, Ao F, Jing MZ, She YL, Wu ZH, Ye LB.
HCV NS4B induces apoptosis through the mitochondrial death pathway.
Virus Res. 2012 Oct;169(1):1-7.
67.Li Z, Chen J, Lei T, Zhang H.
Tamoxifen induces apoptosis of mouse microglia cell line BV-2 cells via both mitochondrial anddeath receptor pathways.
J Huazhong Univ Sci Technolog Med Sci. 2012 Apr;32(2):221-6.
68.Khan M, Ding C, Rasul A, Yi F, Li T, Gao H, Gao R, Zhong L, Zhang K, Fang X, Ma T.
Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinomaPANC-1 cells.
Int J Biol Sci. 2012;8(4):533-47.
69.Ding F, Shao ZW, Yang SH, Wu Q, Gao F, Xiong LM.
Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells.
Apoptosis. 2012 Jun;17(6):579-90.
70.Lin CJ, Huang HC, Liu WJ, Jiang ZF.
Biomedical Imaging and Visualization Model of Mitochondrial Dysfunction and Oxidative Stress in Alzheimer Disease.
Applied Mechanics and Materials. 2012;138-9:1179-82.
71.Hua S, Zhang H, Song Y, Li R, Liu J, Wang Y, Quan F, Zhang Y.
High expression of Mfn1 promotes early development of bovine SCNT embryos: improvement of mitochondrial membrane potential and oxidative metabolism.
Mitochondrion. 2012 Mar;12(2):320-7.
72.Cheng L, Wang C, Liu H, Wang F, Zheng L, Zhao J, Chu E, Lin X.
A novel polypeptide extracted from Ciona savignyi induces apoptosis through a mitochondrial-mediated pathwayin human colorectal carcinoma cells.
Clin Colorectal Cancer. 2012 Sep;11(3):207-14.
73.Lu YS, Huang BT, Huang YX.
Reactive oxygen species formation and apoptosis in human peripheral blood mononuclear cell induced by 900MHz mobile phone radiation.
Oxid Med Cell Longev. 2012;2012:740280.
74.Li S, Wu C, Zhu L, Gao J, Fang J, Li D, Fu M, Liang R, Wang L, Cheng M, Yang H.
By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke.
Molecules. 2012 Nov 9;17(11):13403-23.
75.Li XY, Jing CQ, Lei WL, Li J, Wang JJ.
Apoptosis caused by imidazolium-based ionic liquids in PC12 cells.
Ecotoxicol Environ Saf. 2012 Sep;83:102-7.
76.Liu Q, Peng YB, Qi LW, Cheng XL, Xu XJ, Liu LL, Liu EH, Li P.
The Cytotoxicity Mechanism of 6-Shogaol-Treated HeLa Human Cervical Cancer Cells Revealed by Label-FreeShotgun Proteomics and Bioinformatics Analysis.
Evid Based Complement Alternat Med. 2012;2012:278652.
77.Luo GX, Cai J, Lin JZ, Luo WS, Luo HS, Jiang YY, Zhang Y.
Autophagy Inhibition Promotes Gambogic Acid-induced Suppression of Growth and Apoptosis in GlioblastomaCells.
Asian Pac J Cancer Prev. 2012;13(12):6211-6.
78.Liu W, Zheng X, Qu Z, Zhang M, Zhou C, Ma L, Zhang Y.
Effect of 935-MHz phone-simulating electromagnetic radiation on endometrial glandular cells during mouseembryo implantation.
J Huazhong Univ Sci Technolog Med Sci. 2012 Oct;32(5):755-9.
79. 
Wang CQ, Zhang J, Sun YF, Wang D, Li CJ, Li WH, Lu C, Liu Z, Wu H, Hou XF, Chen C, Zhou X.
Detection of Neurotrophin-4 (NT-4) in Ejaculated Bull Spermatozoa and its Effect on SpermatozoaMitochondrial Activity.
Reprod Domest Anim.2013 Feb;48(1):131-6.
80.
Zhang X, Xie P, Zhang X, Zhou W, Zhao S, Zhao Y, Cai Y.
Toxic effects of microcystin-LR on the HepG2 cell line under hypoxic and normoxic conditions.
J Appl Toxicol.2013 Oct;33(10):1180-6.
81.Zhou ZR, Zhong BS, Jia RX, Wan YJ, Zhang YL, Fan YX, Wang LZ, You JH, Wang ZY, Wang F.
Production of myostatin-targeted goat by nuclear transfer from cultured adult somatic cells.
Theriogenology. 2013 Jan 15;79(2):225-33.
82.Yue B, Zhao CR, Xu HM, Li YY, Cheng YN, Ke HN, Yuan Y, Wang RQ, Shi YQ, Lou HX, Qu XJ.
Riccardin D-26, a synthesized macrocyclic bisbibenzyl compound, inhibits human oral squamous carcinoma cells KB and KB/VCR: In vitro and in vivo studies.
Biochim Biophys Acta. 2013 Jan;1830(1):2194-203.
83.Zhang W, Lan Y, Huang Q, Hua Z.
Galangin induces B16F10 melanoma cell apoptosis via mitochondrial pathway and sustained activation of p38MAPK.
Cytotechnology.2013 May;65(3):447-55.
84.Zhang Z, Liu Z, Ma L, Jiang S, Wang Y, Yu H, Yin Q, Cui J, Li Y.
Reversal of multidrug resistance by mitochondrial targeted self-assembled nanocarrier based on stearylamine.
Mol Pharm. 2013 Jun 3;10(6):2426-34.
85.Mo R, Sun Q, Li N, Zhang C.
Intracellular delivery and antitumor effects of pH-sensitive liposomes based on zwitterionic oligopeptide lipids.
Biomaterials. 2013 Apr;34(11):2773-86.
86.Kong D, Zhang F, Wei D, Zhu X, Zhang X, Chen L, Lu Y, Zheng S.
Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells: In vivoand in vitro studies.
J Gastroenterol Hepatol. 2013 Jul;28(7):1223-33.
87.Zhang F, Kong DS, Zhang ZL, Lei N, Zhu XJ, Zhang XP, Chen L, Lu Y, Zheng SZ.
Tetramethylpyrazine induces G0/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK/p53 signaling in hepatic stellate cells in vitro.
Apoptosis. 2013 Feb;18(2):135-49.
88.Chen G, Zhang P, Huang T, Yu W, Lin J, Li P, Chen K.
Polysaccharides from Rhizopus nigricans mycelia induced apoptosis and G2/M arrest in BGC-823 cells.
Carbohydrate Polymers. 2013 Sep;97(2):800–8.
89.
Sun B, Cai Y, Li Y, Li J, Liu K, Li Y, Yang Y.
The nonstructural protein NP1 of human bocavirus 1 induces cell cycle arrest and apoptosis in Hela cells.
Virology.2013 May 25;440(1):75-83.
90.Zhu K,Guo X, Guo X, Peng W,Zhou H.
Protective effects of wheat germ protein isolate hydrolysates (WGPIH) against hydrogen peroxide-induced oxidative stress in PC12 cells.
Food Research International.2013 Aug;53(1):297-303.
91.Li Z,Gao Q.
Induction of apoptosis in HT-29 cells by quercetin through mitochondria-mediated apoptotic pathway.
Animal Cells and Systems.2013;17(3):147-153.
92.Ge YL, Weng XC, Tian T, Ding F, Huang R, Yuan LB, Wu J, Wang TL, Guo PG, Zhou X.
A mitochondria-targeted zinc(II) phthalocyanine for photodynamic therapy.
RSC Advances (Impact Factor: 2.56).2013;31:12839-12846.
93.Liu Z,Yu Y, Yuan Z, Zhang F, Jing C.
Dexamethasone-induced apoptosis in PC12 cellson Orphan Drugs.
Expert opinion on orpahn Drugs.2013 May;32(2 ):34-38.
94.Huang YY, Liu H, Li Y, Pu LJ, Jiang CC, Xu JC, Jiang ZW.
Down-regulation of RIP1 by 2-deoxy-D-glucose sensitizes breast cancer cells to TRAIL-induced apoptosis.
Eur J Pharmacol. 2013 Apr 5;705(1-3):26-34.
95.Wang Y, Xuan Z, Tian S, He G, Du G.
Myricitrin attenuates 6-hydroxydopamine-induced mitochondrial damage and apoptosis in PC12 cells via inhibition of mitochondrial oxidation.
Journal of Functional Foods.2013 Jan;5(1):337-345.
96.Wen YD, Wang H, Kho SH, Rinkiko S, Sheng X, Shen HM, Zhu YZ.
Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidativestress.
PLoS One. 2013;8(2):e53147.
97.Yan H, Zhang S, He J, Yin Y, Wang X, Chen X, Cui F, Li Y, Nie Y, Tian W.
Self-assembled monolayers with different chemical group substrates for the study of MCF-7 breast cancer cell linebehavior.
Biomed Mater.2013 Jun;8(3):035008.
98.Liu L, Gu L, Ma Q, Zhu D, Huang X.
Resveratrol attenuates hydrogen peroxide-induced apoptosis in human umbilical vein endothelial cells.
Eur Rev Med Pharmacol Sci. 2013 Jan;17(1):88-94.
99.Huang L, Wan J, Chen Y, Wang Z, Hui L, Li Y, Xu D, Zhou W.
Inhibitory effects of p38 inhibitor against mitochondrial dysfunction in the early brain injury after subarachnoidhemorrhage in mice.
Brain Res. 2013 Jun 23;1517:133-40.
100.Yang F, Sun X, Shen J, Yu LP, Liang JY, Zheng HQ, Wu ZD.
A recombined protein (rSj16) derived from Schistosoma japonicum induces cell cycle arrest and apoptosis ofmurine myeloid leukemia cells.
Parasitol Res.2013 Mar;112(3):1261-72.
101.Zhang D, Gao X, Wang Q, Qin M, Liu K, Huang F, Liu B.
Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species-associatedinflammation.
J Diabetes. 2013 Mar;5(1):13-24.
102.
Liu Z, Dong X, Song L, Zhang H, Liu L, Zhu D, Song C, Leng X.
Carboxylation of multiwalled carbon nanotube enhanced its biocompatibility with L02 cells through decreasedactivation of mitochondrial apoptotic pathway.
J Biomed Mater Res A.2014 Mar;102(3):665-73.
103.Li X, Tao H, Xie K, Ni Z, Yan Y, Wei K, Chuang PY, He JC, Gu L.
cAMP signaling prevents podocyte apoptosis via activation of protein kinase A and mitochondrial fusion.
PLoS One. 2014 Mar 18;9(3):e92003.
104.Sun J, Bai S, Bai W, Zou F, Zhang L, Li G, Hu Y, Li M, Yan R, Su Z, Huang Y.
1,3-Dichloro-2-propanol inhibits progesterone production through the expression of steroidogenic enzymes and cAMP concentration in Leydig cells.
Food Chem. 2014 Jul 1;154:330-6.
105.Chang C, Wu G, Gao P, Yang L, Liu W, Zuo J.
Upregulated Parkin expression protects mitochondrial homeostasis in DJ-1 konckdown cells and cells overexpressing the DJ-1 L166P mutation.
Mol Cell Biochem. 2014 Feb;387(1-2):187-95.
106.Yang L, Di G, Qi X, Qu M, Wang Y, Duan H, Danielson P, Xie L, Zhou Q.
Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor.
Diabetes. 2014 Dec;63(12):4262-74.
107.Li D, Ye Y, Lin S, Deng L, Fan X, Zhang Y, Deng X, Li Y, Yan H, Ma Y.
Evaluation of deoxynivalenol-induced toxic effects on DF-1 cells in vitro: cell-cycle arrest, oxidative stress, and apoptosis.
Environ Toxicol Pharmacol. 2014 Jan;37(1):141-9.
108.He M, Dong C, Xie Y, Li J, Yuan D, Bai Y, Shao C.
Reciprocal bystander effect between α-irradiated macrophage and hepatocyte is mediated by cAMP through a membrane signaling pathway.
Mutat Res Fundam Mol Mech Mutagen. 2014 Mar 20;763-764C:1-9.
109.
Tang C, Liang J, Qian J, Jin L, Du M, Li M, Li D.
Opposing role of JNK-p38 kinase and ERK1/2 in hydrogen peroxide-induced oxidative damage of human trophoblast-like JEG-3 cells.
Int J Clin Exp Pathol. 2014 Feb 15;7(3):959-68.
110.Chu JH, Zhao CR, Song ZY, Wang RQ, Qin YZ, Li WB, Qu XJ.
1082-39, an analogue of sorafenib, inhibited human cancer cell growth more potently than sorafenib.
Biomed Pharmacother. 2014 Apr;68(3):335-41.
111.
Pan H, Cheng L, Yang H, Zou W, Cheng R, Hu T.
Lysophosphatidic acid rescues human dental pulp cells from ischemia-induced apoptosis.
J Endod. 2014 Feb;40(2):217-22. 
112.Zheng L, Sun X, Zhu X, Lv F, Zhong Z, Zhang F, Guo W, Cao W, Yang L, Tian Y.
Apoptosis of THP-1 derived macrophages induced by sonodynamic therapy using a new sonosensitizer hydroxyl acetylated curcumin.
PLoS One. 2014 Mar 27;9(3):e93133.
113.Cui SX, Zhang HL, Xu WF, Qu XJ.
13F-1, a novel 5-fluorouracil prodrug containing an Asn-Gly-Arg (NO2) COOCH3 tripeptide, inhibits human colonic carcinoma growth by targeting Aminopeptidase N (APN/CD13).
Eur J Pharmacol. 2014 Jul 5;734:50-9.
114.Fang L, Bai C, Chen Y, Dai J, Xiang Y, Ji X, Huang C, Dong Q.
Inhibition of ROS production through mitochondria-targeted antioxidant and mitochondrial uncoupling increases post-thaw sperm viability in yellow catfish.
Cryobiology. 2014 Dec;69(3):386-93.
115.Wang C, Xia W, Jiang Q, Xu Y, Yu P.
Differential effects of lipid fractions from silver carp brain on human cervical carcinoma cells in vitro.
Food Funct. 2014 Sep;5(9):2194-201.
116.Fan S, Li X, Lin J, Chen S, Shan J, Qi G.
Honokiol inhibits tumor necrosis factor-α-stimulated rat aortic smooth muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis.
Inflammation. 2014 Feb;37(1):17-26.
117.Guo P, Pi H, Xu S, Zhang L, Li Y, Li M, Cao Z, Tian L, Xie J, Li R, He M, Lu Y, Liu C, Duan W, Yu Z, Zhou Z.
Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro.
Toxicol Sci.2014 Nov;142(1):182-95.
118.Li D, Ma H, Ye Y, Ji C, Tang X, Ouyang D, Chen J, Li Y, Ma Y.
Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway.
Environ Toxicol Pharmacol. 2014 Jul;38(1):163-71.
119.Liu L, Li T, Tan J, Fu J, Guo Q, Ji H, Zhang Y.
NG as a novel nitric oxide donor induces apoptosis by increasing reactive oxygen species and inhibiting mitochondrial function in MGC803 cells.
Int Immunopharmacol. 2014 Aug 16;23(1):27-36.
120.Zhang X, Yu Q, Jiang W, Bi Y, Zhang Y, Gong M, Wei X, Li T, Chen J.
All-trans retinoic acid suppresses apoptosis in PC12 cells injured by oxygen and glucose deprivation via the retinoic acid receptor α signaling pathway.
Mol Med Rep. 2014 Nov;10(5):2549-55.
121.Jiang L, Zhao MN, Liu TY, Wu XS, Weng H, Ding Q, Shu YJ, Bao RF, Li ML, Mu JS, Wu WG, Ding QC, Cao Y, Hu YP, Shen BY, Tan ZJ, Liu YB.
Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells.
Tumour Biol. 2014 Nov;35(11):10931-41.
122.
Sun ZB, Wang JW, Xiao H, Zhang QS, Kan WS, Mo FB, Hu S, Ye SN.
Icariin may benefit the mesenchymal stem cells of patients with steroid-associated osteonecrosis by ABCB1-promoter demethylation: a preliminary study.
Osteoporos Int. 2015 Jan;26(1):187-97.
123.
Pan HY, Yang H, Shao MY, Xu J, Zhang P, Cheng R, Hu T.
Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.
Int Endod J. 2015 May;48(5):460-8.
124. Yan X, Yang X, Hao X, Ren Q, Gao J, Wang Y, Chang N, Qiu Y, Song G.
Sodium Fluoride Induces Apoptosis in H9c2 Cardiomyocytes by Altering Mitochondrial Membrane Potential and Intracellular ROS Level.
Biol Trace Elem Res.2015 Aug;166(2):210-5.
125.Li H, Jia Z, Li G, Zhao X, Sun P, Wang J, Fan Z, Lv G.
Neuroprotective effects of exendin-4 in rat model of spinal cord injury via inhibiting mitochondrial apoptotic pathway.
Int J Clin Exp Pathol. 2015 May 1;8(5):4837-43.
126.Lin P, Liu J, Ren M, Ji K, Li L, Zhang B, Gong Y, Yan C.
Idebenone protects against oxidized low density lipoprotein induced mitochondrial dysfunction in vascular endothelial cells via GSK3β/β-catenin signalling pathways.
Biochem Biophys Res Commun. 2015 Sep 25;465(3):548-55.
127.Ye X, Han Y, Zhang L, Liu W, Zuo J.
MTERF4 regulates the mitochondrial dysfunction induced by MPP+ in SH-SY5Y cells.
Biochem Biophys Res Commun. 2015 Aug 14;464(1):214-20.
128.Zhang B, Peng X, Li G, Xu Y, Xia X, Wang Q.
Oxidative stress is involved in Patulin induced apoptosis in HEK293 cells.
Toxicon.2015 Feb;94:1-7.
129.Wang W, Xie Q, Zhou X, Yao J, Zhu X, Huang P, Zhang L, Wei J, Xie H, Zhou L, Zheng S.
Mitofusin-2 triggers mitochondria Ca 2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells.
Cancer Lett.2015 Mar 1;358(1):47-58.
130.Xiong Y, Wu X, Rao L.
Tetrastigma hemsleyanum (Sanyeqing) root tuber extracts induces apoptosis in human cervical carcinoma HeLa cells.
J Ethnopharmacol. 2015 May 13;165:46-53.
131.Zhao L, Feng Y, Shi A, Zong Y, Wan M.
Apoptosis Induced by Microbubble-Assisted Acoustic Cavitation in K562 Cells: The Predominant Role of the Cyclosporin A-Dependent Mitochondrial Permeability Transition Pore.
Ultrasound Med Biol. 2015 Oct;41(10):2755-64.
132.Wang P, Peng X, Wei ZF, Wei FY, Wang W, Ma WD, Yao LP, Fu YJ, Zu YG.
Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway.
Biochim Biophys Acta. 2015 Sep;1850(9):1751-61.
133.
Yang J, Liu D, He Y, Wang L. 
Mitochondrial energy metabolism in the hepatopancreas of freshwater crabs (Sinopotamon henanense) after cadmium exposure.
Environ Sci Process Impacts.2015 Jan;17(1):156-65.
134.Zong Y, Huang Y, Chen S, Zhu M, Chen Q, Feng S, Sun Y, Zhang Q, Tang C, Du J, Jin H.
Downregulation of Endogenous Hydrogen Sulfide Pathway Is Involved in Mitochondrion-Related Endothelial Cell Apoptosis Induced by High Salt.
Oxid Med Cell Longev. 2015;2015:754670.
135.Zhang J, Wu D, Xing Z, Liang S, Han H, Shi H, Zhang Y, Yang Y, Li Q.
N-Isopropylacrylamide-modified polyethylenimine-mediated p53 gene delivery to prevent the proliferation of cancer cells.
Colloids Surf B Biointerfaces. 2015 May 1;129:54-62.
136.
Ding C, Wu Z, Huang L, Wang Y, Xue J, Chen S, Deng Z, Wang L, Song Z, Chen S.
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure. 
Sci Rep.2015 Nov 4;5:16064.
137.Xin L, Ma X, Xiao Z, Yao H, Liu Z.
Coxsackievirus B3 induces autophagy in HeLa cells via the AMPK/MEK/ERK and Ras/Raf/MEK/ERK signaling pathways.
Infect Genet Evol. 2015 Dec;36:46-54.
138.Wu J, Zhu D, Zhang J, Li G, Liu Z, Sun J.
Lithium protects against methamphetamine-induced neurotoxicity in PC12 cells via Akt/GSK3β/mTOR pathway.
Biochem Biophys Res Commun.2015 Sep 25;465(3):368-73.
139.Wang AT, Liang DS, Liu YJ, Qi XR.
Roles of ligand and TPGS of micelles in regulating internalization, penetration and accumulation against sensitive or resistant tumor and therapy for multidrug resistant tumors.
Biomaterials.2015 Jun;53:160-72.
140.Lu Z, Lu F, Zheng Y, Zeng Y, Zou C, Liu X.
Grape seed proanthocyanidin extract protects human umbilical vein endothelial cells from indoxyl sulfate-induced injury via ameliorating mitochondrial dysfunction.
Ren Fail.2015 Oct 29:1-9.
141.Yang J, Liu D, Dahms HU, Wang L.
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