线粒体膜电位检测试剂盒(JC-1)(Mitochondrial membrane potential assay kit with JC-1)是一种以JC-1为荧光探针，快速灵敏地检测细胞、组织或纯化的线粒体膜电位变化的试剂盒，可以用于早期的细胞凋亡检测。
      JC-1是一种广泛用于检测线粒体膜电位(mitochondrial membrane potential)△Ψm的理想荧光探针。可以检测细胞、组织或纯化的线粒体膜电位。在线粒体膜电位较高时，JC-1聚集在线粒体的基质(matrix)中，形成聚合物(J-aggregates)，可以产生红色荧光；在线粒体膜电位较低时，JC-1不能聚集在线粒体的基质中，此时JC-1为单体(monomer)，可以产生绿色荧光。这样就可以非常方便地通过荧光颜色的转变来检测线粒体膜电位的变化。常用红绿荧光的相对比例来衡量线粒体去极化的比例。
      线粒体膜电位的下降是细胞凋亡早期的一个标志性事件。通过JC-1从红色荧光到绿色荧光的转变可以很容易地检测到细胞膜电位的下降，同时也可以用JC-1从红色荧光到绿色荧光的转变作为细胞凋亡早期的一个检测指标。
      JC-1单体的最大激发波长为514nm，最大发射波长为529nm；JC-1聚合物(J-aggregates)的最大激发波长为585nm，最大发射波长为590nm。实际观察时，使用常规的观察红色荧光和绿色荧光的设置即可。
      本试剂盒提供了CCCP作为诱导线粒体膜电位下降的阳性对照。
      对于六孔板中的样品，本试剂盒共可以检测100个样品；对于12孔中的样品，本试剂盒共可以检测200个样品。
包装清单：

保存条件：
      -20℃保存。JC-1(200X)需避光保存，并尽量避免反复冻融。超纯水和JC-1染色缓冲液(5X)也可4℃保存。
注意事项：
      JC-1(200X)在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内，可以20-25℃水浴温育片刻至全部融解后使用。
      必须先把JC-1(200X)用试剂盒提供的超纯水充分溶解混匀后，才可以加入JC-1染色缓冲液(5X)。不可先配制JC-1染色缓冲液(1X)再加入JC-1(200X)，这样JC-1会很难充分溶解，会严重影响后续的检测。
      装载完JC-1后用JC-1染色缓冲液(1X)洗涤时，使JC-1染色缓冲液(1X)保持4℃左右，此时的洗涤效果较好。
      JC-1探针装载完并洗涤后尽量在30分钟内完成后续检测。在检测前需冰浴保存。
      请勿把JC-1染色缓冲液(5X)全部配制成JC-1染色缓冲液(1X)，本试剂盒使用过程中需直接使用JC-1染色缓冲液(5X)。
      如果发现JC-1染色缓冲液(5X)中有沉淀，必须全部溶解后才能使用，为促进溶解可以在37℃加热。
      CCCP为线粒体电子传递链抑制剂，对人体有害，操作时请小心，并注意有效防护以避免直接接触人体或吸入体内。
      本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
      为了您的安全和健康，请穿实验服并戴一次性手套操作

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86.Kong D, Zhang F, Wei D, Zhu X, Zhang X, Chen L, Lu Y, Zheng S.
Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells: In vivoand in vitro studies.
J Gastroenterol Hepatol. 2013 Jul;28(7):1223-33.
87.Zhang F, Kong DS, Zhang ZL, Lei N, Zhu XJ, Zhang XP, Chen L, Lu Y, Zheng SZ.
Tetramethylpyrazine induces G0/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK/p53 signaling in hepatic stellate cells in vitro.
Apoptosis. 2013 Feb;18(2):135-49.
88.Chen G, Zhang P, Huang T, Yu W, Lin J, Li P, Chen K.
Polysaccharides from Rhizopus nigricans mycelia induced apoptosis and G2/M arrest in BGC-823 cells.
Carbohydrate Polymers. 2013 Sep;97(2):800–8.
89.Sun B, Cai Y, Li Y, Li J, Liu K, Li Y, Yang Y.
The nonstructural protein NP1 of human bocavirus 1 induces cell cycle arrest and apoptosis in Hela cells.
Virology.2013 May 25;440(1):75-83.
90.Zhu K，Guo X, Guo X, Peng W,Zhou H.
Protective effects of wheat germ protein isolate hydrolysates (WGPIH) against hydrogen peroxide-induced oxidative stress in PC12 cells.
Food Research International.2013 Aug;53(1):297-303.
91.Li Z,Gao Q.
Induction of apoptosis in HT-29 cells by quercetin through mitochondria-mediated apoptotic pathway.
Animal Cells and Systems.2013;17(3):147-153.
92.Ge YL, Weng XC, Tian T, Ding F, Huang R, Yuan LB, Wu J, Wang TL, Guo PG, Zhou X.
A mitochondria-targeted zinc(II) phthalocyanine for photodynamic therapy.
RSC Advances (Impact Factor: 2.56).2013;31:12839-12846.
93.Liu Z,Yu Y, Yuan Z, Zhang F, Jing C.
Dexamethasone-induced apoptosis in PC12 cellson Orphan Drugs.
Expert opinion on orpahn Drugs.2013 May;32(2 ):34-38.
94.Huang YY, Liu H, Li Y, Pu LJ, Jiang CC, Xu JC, Jiang ZW.
Down-regulation of RIP1 by 2-deoxy-D-glucose sensitizes breast cancer cells to TRAIL-induced apoptosis.
Eur J Pharmacol. 2013 Apr 5;705(1-3):26-34.
95.Wang Y, Xuan Z, Tian S, He G, Du G.
Myricitrin attenuates 6-hydroxydopamine-induced mitochondrial damage and apoptosis in PC12 cells via inhibition of mitochondrial oxidation.
Journal of Functional Foods.2013 Jan;5(1):337-345.
96.Wen YD, Wang H, Kho SH, Rinkiko S, Sheng X, Shen HM, Zhu YZ.
Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidativestress.
PLoS One. 2013;8(2):e53147.
97.Yan H, Zhang S, He J, Yin Y, Wang X, Chen X, Cui F, Li Y, Nie Y, Tian W.
Self-assembled monolayers with different chemical group substrates for the study of MCF-7 breast cancer cell linebehavior.
Biomed Mater.2013 Jun;8(3):035008.
98.Liu L, Gu L, Ma Q, Zhu D, Huang X.
Resveratrol attenuates hydrogen peroxide-induced apoptosis in human umbilical vein endothelial cells.
Eur Rev Med Pharmacol Sci. 2013 Jan;17(1):88-94.
99.Huang L, Wan J, Chen Y, Wang Z, Hui L, Li Y, Xu D, Zhou W.
Inhibitory effects of p38 inhibitor against mitochondrial dysfunction in the early brain injury after subarachnoidhemorrhage in mice.
Brain Res. 2013 Jun 23;1517:133-40.
100.Yang F, Sun X, Shen J, Yu LP, Liang JY, Zheng HQ, Wu ZD.
A recombined protein (rSj16) derived from Schistosoma japonicum induces cell cycle arrest and apoptosis ofmurine myeloid leukemia cells.
Parasitol Res.2013 Mar;112(3):1261-72.
101.Zhang D, Gao X, Wang Q, Qin M, Liu K, Huang F, Liu B.
Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species-associatedinflammation.
J Diabetes. 2013 Mar;5(1):13-24.
102.Liu Z, Dong X, Song L, Zhang H, Liu L, Zhu D, Song C, Leng X.
Carboxylation of multiwalled carbon nanotube enhanced its biocompatibility with L02 cells through decreasedactivation of mitochondrial apoptotic pathway.
J Biomed Mater Res A.2014 Mar;102(3):665-73.
103.Li X, Tao H, Xie K, Ni Z, Yan Y, Wei K, Chuang PY, He JC, Gu L.
cAMP signaling prevents podocyte apoptosis via activation of protein kinase A and mitochondrial fusion.
PLoS One. 2014 Mar 18;9(3):e92003.
104.Sun J, Bai S, Bai W, Zou F, Zhang L, Li G, Hu Y, Li M, Yan R, Su Z, Huang Y.
1,3-Dichloro-2-propanol inhibits progesterone production through the expression of steroidogenic enzymes and cAMP concentration in Leydig cells.
Food Chem. 2014 Jul 1;154:330-6.
105.Chang C, Wu G, Gao P, Yang L, Liu W, Zuo J.
Upregulated Parkin expression protects mitochondrial homeostasis in DJ-1 konckdown cells and cells overexpressing the DJ-1 L166P mutation.
Mol Cell Biochem. 2014 Feb;387(1-2):187-95.
106.Yang L, Di G, Qi X, Qu M, Wang Y, Duan H, Danielson P, Xie L, Zhou Q.
Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor.
Diabetes. 2014 Dec;63(12):4262-74.
107.Li D, Ye Y, Lin S, Deng L, Fan X, Zhang Y, Deng X, Li Y, Yan H, Ma Y.
Evaluation of deoxynivalenol-induced toxic effects on DF-1 cells in vitro: cell-cycle arrest, oxidative stress, and apoptosis.
Environ Toxicol Pharmacol. 2014 Jan;37(1):141-9.
108.He M, Dong C, Xie Y, Li J, Yuan D, Bai Y, Shao C.
Reciprocal bystander effect between α-irradiated macrophage and hepatocyte is mediated by cAMP through a membrane signaling pathway.
Mutat Res Fundam Mol Mech Mutagen. 2014 Mar 20;763-764C:1-9.
109.Tang C, Liang J, Qian J, Jin L, Du M, Li M, Li D.
Opposing role of JNK-p38 kinase and ERK1/2 in hydrogen peroxide-induced oxidative damage of human trophoblast-like JEG-3 cells.
Int J Clin Exp Pathol. 2014 Feb 15;7(3):959-68.
110.Chu JH, Zhao CR, Song ZY, Wang RQ, Qin YZ, Li WB, Qu XJ.
1082-39, an analogue of sorafenib, inhibited human cancer cell growth more potently than sorafenib.
Biomed Pharmacother. 2014 Apr;68(3):335-41.
111.Pan H, Cheng L, Yang H, Zou W, Cheng R, Hu T.
Lysophosphatidic acid rescues human dental pulp cells from ischemia-induced apoptosis.
J Endod. 2014 Feb;40(2):217-22. 
112.Zheng L, Sun X, Zhu X, Lv F, Zhong Z, Zhang F, Guo W, Cao W, Yang L, Tian Y.
Apoptosis of THP-1 derived macrophages induced by sonodynamic therapy using a new sonosensitizer hydroxyl acetylated curcumin.
PLoS One. 2014 Mar 27;9(3):e93133.
113.Cui SX, Zhang HL, Xu WF, Qu XJ.
13F-1, a novel 5-fluorouracil prodrug containing an Asn-Gly-Arg (NO2) COOCH3 tripeptide, inhibits human colonic carcinoma growth by targeting Aminopeptidase N (APN/CD13).
Eur J Pharmacol. 2014 Jul 5;734:50-9.
114.Fang L, Bai C, Chen Y, Dai J, Xiang Y, Ji X, Huang C, Dong Q.
Inhibition of ROS production through mitochondria-targeted antioxidant and mitochondrial uncoupling increases post-thaw sperm viability in yellow catfish.
Cryobiology. 2014 Dec;69(3):386-93.
115.Wang C, Xia W, Jiang Q, Xu Y, Yu P.
Differential effects of lipid fractions from silver carp brain on human cervical carcinoma cells in vitro.
Food Funct. 2014 Sep;5(9):2194-201.
116.Fan S, Li X, Lin J, Chen S, Shan J, Qi G.
Honokiol inhibits tumor necrosis factor-α-stimulated rat aortic smooth muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis.
Inflammation. 2014 Feb;37(1):17-26.
117.Guo P, Pi H, Xu S, Zhang L, Li Y, Li M, Cao Z, Tian L, Xie J, Li R, He M, Lu Y, Liu C, Duan W, Yu Z, Zhou Z.
Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro.
Toxicol Sci.2014 Nov;142(1):182-95.
118.Li D, Ma H, Ye Y, Ji C, Tang X, Ouyang D, Chen J, Li Y, Ma Y.
Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway.
Environ Toxicol Pharmacol. 2014 Jul;38(1):163-71.
119.Liu L, Li T, Tan J, Fu J, Guo Q, Ji H, Zhang Y.
NG as a novel nitric oxide donor induces apoptosis by increasing reactive oxygen species and inhibiting mitochondrial function in MGC803 cells.
Int Immunopharmacol. 2014 Aug 16;23(1):27-36.
120.Zhang X, Yu Q, Jiang W, Bi Y, Zhang Y, Gong M, Wei X, Li T, Chen J.
All-trans retinoic acid suppresses apoptosis in PC12 cells injured by oxygen and glucose deprivation via the retinoic acid receptor α signaling pathway.
Mol Med Rep. 2014 Nov;10(5):2549-55.
121.Jiang L, Zhao MN, Liu TY, Wu XS, Weng H, Ding Q, Shu YJ, Bao RF, Li ML, Mu JS, Wu WG, Ding QC, Cao Y, Hu YP, Shen BY, Tan ZJ, Liu YB.
Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells.
Tumour Biol. 2014 Nov;35(11):10931-41.
122.Sun ZB, Wang JW, Xiao H, Zhang QS, Kan WS, Mo FB, Hu S, Ye SN.
Icariin may benefit the mesenchymal stem cells of patients with steroid-associated osteonecrosis by ABCB1-promoter demethylation: a preliminary study.
Osteoporos Int. 2015 Jan;26(1):187-97.
123.Pan HY, Yang H, Shao MY, Xu J, Zhang P, Cheng R, Hu T.
Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.
Int Endod J. 2015 May;48(5):460-8.
124. Yan X, Yang X, Hao X, Ren Q, Gao J, Wang Y, Chang N, Qiu Y, Song G.
Sodium Fluoride Induces Apoptosis in H9c2 Cardiomyocytes by Altering Mitochondrial Membrane Potential and Intracellular ROS Level.
Biol Trace Elem Res.2015 Aug;166(2):210-5.
125.Li H, Jia Z, Li G, Zhao X, Sun P, Wang J, Fan Z, Lv G.
Neuroprotective effects of exendin-4 in rat model of spinal cord injury via inhibiting mitochondrial apoptotic pathway.
Int J Clin Exp Pathol. 2015 May 1;8(5):4837-43.
126.Lin P, Liu J, Ren M, Ji K, Li L, Zhang B, Gong Y, Yan C.
Idebenone protects against oxidized low density lipoprotein induced mitochondrial dysfunction in vascular endothelial cells via GSK3β/β-catenin signalling pathways.
Biochem Biophys Res Commun. 2015 Sep 25;465(3):548-55.
127.Ye X, Han Y, Zhang L, Liu W, Zuo J.
MTERF4 regulates the mitochondrial dysfunction induced by MPP+ in SH-SY5Y cells.
Biochem Biophys Res Commun. 2015 Aug 14;464(1):214-20.
128.Zhang B, Peng X, Li G, Xu Y, Xia X, Wang Q.
Oxidative stress is involved in Patulin induced apoptosis in HEK293 cells.
Toxicon.2015 Feb;94:1-7.
129.Wang W, Xie Q, Zhou X, Yao J, Zhu X, Huang P, Zhang L, Wei J, Xie H, Zhou L, Zheng S.
Mitofusin-2 triggers mitochondria Ca 2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells.
Cancer Lett.2015 Mar 1;358(1):47-58.
130.Xiong Y, Wu X, Rao L.
Tetrastigma hemsleyanum (Sanyeqing) root tuber extracts induces apoptosis in human cervical carcinoma HeLa cells.
J Ethnopharmacol. 2015 May 13;165:46-53.
131.Zhao L, Feng Y, Shi A, Zong Y, Wan M.
Apoptosis Induced by Microbubble-Assisted Acoustic Cavitation in K562 Cells: The Predominant Role of the Cyclosporin A-Dependent Mitochondrial Permeability Transition Pore.
Ultrasound Med Biol. 2015 Oct;41(10):2755-64.
132.Wang P, Peng X, Wei ZF, Wei FY, Wang W, Ma WD, Yao LP, Fu YJ, Zu YG.
Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway.
Biochim Biophys Acta. 2015 Sep;1850(9):1751-61.
133.Yang J, Liu D, He Y, Wang L. 
Mitochondrial energy metabolism in the hepatopancreas of freshwater crabs (Sinopotamon henanense) after cadmium exposure.
Environ Sci Process Impacts.2015 Jan;17(1):156-65.
134.Zong Y, Huang Y, Chen S, Zhu M, Chen Q, Feng S, Sun Y, Zhang Q, Tang C, Du J, Jin H.
Downregulation of Endogenous Hydrogen Sulfide Pathway Is Involved in Mitochondrion-Related Endothelial Cell Apoptosis Induced by High Salt.
Oxid Med Cell Longev. 2015;2015:754670.
135.Zhang J, Wu D, Xing Z, Liang S, Han H, Shi H, Zhang Y, Yang Y, Li Q.
N-Isopropylacrylamide-modified polyethylenimine-mediated p53 gene delivery to prevent the proliferation of cancer cells.
Colloids Surf B Biointerfaces. 2015 May 1;129:54-62.
136.Ding C, Wu Z, Huang L, Wang Y, Xue J, Chen S, Deng Z, Wang L, Song Z, Chen S.
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure. 
Sci Rep.2015 Nov 4;5:16064.
137.Xin L, Ma X, Xiao Z, Yao H, Liu Z.
Coxsackievirus B3 induces autophagy in HeLa cells via the AMPK/MEK/ERK and Ras/Raf/MEK/ERK signaling pathways.
Infect Genet Evol. 2015 Dec;36:46-54.
138.Wu J, Zhu D, Zhang J, Li G, Liu Z, Sun J.
Lithium protects against methamphetamine-induced neurotoxicity in PC12 cells via Akt/GSK3β/mTOR pathway.
Biochem Biophys Res Commun.2015 Sep 25;465(3):368-73.
139.Wang AT, Liang DS, Liu YJ, Qi XR.
Roles of ligand and TPGS of micelles in regulating internalization, penetration and accumulation against sensitive or resistant tumor and therapy for multidrug resistant tumors.
Biomaterials.2015 Jun;53:160-72.
140.Lu Z, Lu F, Zheng Y, Zeng Y, Zou C, Liu X.
Grape seed proanthocyanidin extract protects human umbilical vein endothelial cells from indoxyl sulfate-induced injury via ameliorating mitochondrial dysfunction.
Ren Fail.2015 Oct 29:1-9.
141.Yang J, Liu D, Dahms HU, Wang L.
Cadmium inhibits the vitellogenesis of freshwater crab Sinopotamon henanense.
Environ Toxicol Chem.2015 Jul;34(7):1609-16.
142.Li X, Song Y, Zhang P, Zhu H, Chen L, Xiao Y1, Xing Y. 
Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.
Tumour Biol. 2016;37(6):7599-7613.
143.Peng X, Zhang YY, Wang J, Ji Q.
Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells.
Tumour Biol. 2016;37(1): 865-76.
144.Qiu J, Liu X, Li X, Zhang X, Han P, Zhou H, Shao L, Hou Y, Min Y, Kong Z, Wang Y, Wei Y, Liu X, Ni H, Peng J, Hou M.
CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immunethrombocytopenia. 
Sci Rep. 2016 Jun 20;6:27445. 
145.Peng X, Gan J, Wang Q, Shi Z, Xia X.
3-Monochloro-1,2-propanediol (3-MCPD) induces apoptosis via mitochondrial oxidative phosphorylationsystem impairment and the caspase cascade pathway.
Toxicology. 2016 Nov 30;372:1-11.
146.Peng X, Zhang YY, Wang J, Ji Q.
Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells.
Tumour Biol. 2016 Jan;37(1):865-76.
147.Yang H, Yang R, Liu H, Ren Z, Wang C, Li D, Ma X.
Knockdown of peroxisome proliferator-activated receptor gamma coactivator-1 alpha increasedapoptosis of human endometrial cancer HEC-1A cells.
Onco Targets Ther. 2016 Aug 24;9:5329-38.
148.Bai L, Guo Y, Du Y, Wang H, Zhao Z, Huang Y, Tang J.
47kDa isoform of Annexin A7 affecting the apoptosis of mouse hepatocarcinoma cells line.
Biomed Pharmacother. 2016 Oct;83:1127-1131.
149.Yu S, Zheng S, Leng J, Wang S, Zhao T, Liu J.
Inhibition of mitochondrial calcium uniporter protects neurocytes from ischemia/reperfusion injury viathe inhibition of excessive mitophagy.
Neurosci Lett. 2016 Aug 15;628:24-9.
150.Jiang K, Mei SQ, Wang TT, Pan JH, Chen YH, Cai J.
Vip3Aa induces apoptosis in cultured Spodoptera frugiperda (Sf9) cells.
Toxicon. 2016 Sep 15;120:49-56.
151.Li X, Song Y, Zhang P, Zhu H, Chen L, Xiao Y, Xing Y.
Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.
Tumour Biol.2016 Jun;37(6):7599-613.
152.Fu X, Gao X, Ge L, Cui X, Su C, Yang W, Sun X, Zhang W, Yao Z, Yang X, Yang J.
Malonate induces the assembly of cytoplasmic stress granules.
FEBS Lett. 2016 Jan;590(1):22-33.
153.Liu Y, Zhi D, Li M, Liu D, Wang X, Wu Z, Zhang Z, Fei D, Li Y, Zhu H, Xie Q, Yang H, Li H.
Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by openingmitochondrial permeability transition pore via regulating cyclophilin D.
Sci Rep. 2016 Dec 16;6:38934.
154.Liu Y, Gao M, Ma MM, Tang YB, Zhou JG, Wang GL, Du YH, Guan YY.
Endophilin A2 protects H2O2-induced apoptosis by blockade of Bax translocation in rat basilar artery smooth muscle cells.
J Mol Cell Cardiol. 2016 Mar;92:122-33.
155.Liu Q, Sun Y, Lv Y, Le Z, Xin Y, Zhang P, Liu Y.
TERT alleviates irradiation-induced late rectal injury by reducing hypoxia-induced ROS levels through the activation of NF-κB and autophagy.
Int J Mol Med. 2016 Sep;38(3):785-93.
156.Zhang E, Yin S, Song X, Fan L, Hu H.
Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ERstress/GSK-3-mediated mitochondrial pathway.
Sci Rep. 2016 Nov 30;6:38138.
157.Zhang X, Wang L, Wang R, Luo X, Li Y, Chen Z.
Protective effects of rice dreg protein hydrolysates against hydrogen peroxide-induced oxidative stressin HepG-2 cells.
Food Funct. 2016 Mar;7(3):1429-37.
158.Zhang F, Zhu X, Gong J, Sun Y, Chen D, Wang J, Wang Y, Guo M, Li W.
Lysosome-mitochondria-mediated apoptosis specifically evoked in cancer cells induced by goldnanorods.
Nanomedicine (Lond). 2016 Aug;11(15):1993-2006.
159.Zhang JY, Deng YN, Zhang M, Su H, Qu QM .
SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model.
Neurochem Res. 2016 Jul;41(7):1761-73.
160.Liu MP, Liao M, Dai C, Chen JF, Yang CJ, Liu M, Chen ZG, Yao MC.
Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cellsby promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway.
Sci Rep.2016 Sep 27;6:34245.
161.Liu T, Yuan X, Jia T, Liu C, Ni Z, Qin Z, Yuan Y.
Polymeric prodrug of bufalin for increasing solubility and stability: Synthesis and anticancer study invitro and in vivo.
Int J Pharm. 2016 Jun 15;506(1-2):382-93.
162.Liu X, Zhang Y, Wang Y, Yan Y, Wang J, Gu J, Chun B, Liu Z.
Investigation of cadmium-induced apoptosis and the protective effect of N-acetylcysteine in BRL 3Acells.
Mol Med Rep. 2016 Jul;14(1):373-9. 
163.Kang WL, Xu GS.
Atrasentan increased the expression of klotho by mediating miR-199b-5p and prevented renal tubularinjury in diabetic nephropathy.
Sci Rep. 2016 Jan 27;6:19979.
164.Dong K, Yan Y, Wang P, Shi X, Zhang L, Wang K, Xing J, Dong Y.
Biodegradable mixed MPEG-SS-2SA/TPGS micelles for triggered intracellular release of paclitaxel andreversing multidrug resistance.
Int J Nanomedicine. 2016 Oct 6;11:5109-5123.
165.Wang M, Li Y, HuangFu M, Xiao Y, Zhang T, Han M, Xu D, Li F, Ling D, Jin Y, Gao J.
Pluronic-attached polyamidoamine dendrimer conjugates overcome drug resistance in breast cancer.
Nanomedicine (Lond). 2016 Nov;11(22):2917-2934.
166.Lu Z, Lu F, Zheng Y, Zeng Y, Zou C, Liu X.
Grape seed proanthocyanidin extract protects human umbilical vein endothelial cells from indoxylsulfate-induced injury via ameliorating mitochondrial dysfunction.
Ren Fail. 2016;38(1):100-8.
167.Duan YT, Man RJ, Tang DJ, Yao YF, Tao XX, Yu C, Liang XY, Makawana JA, Zou MJ, Wang ZC, Zhu HL.
Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4(CA-4) Analogues as Potent Antitubulin Agents.
Sci Rep. 2016 May 3;6:25387.
168.Luo SW, Wang WN, Sun ZM, Xie FX, Kong JR, Liu Y, Cheng CH.
Molecular cloning, characterization and expression analysis of (B-cell lymphoma-2 associated X protein)Bax in the orange-spotted grouper (Epinephelus coioides) after the Vibrio alginolyticus challenge.
Dev Comp Immunol. 2016 Jul;60:66-79.
169.He L, Xiao D, Feng J, Yao C, Tang L.
Induction of apoptosis of liver cancer cells by nanosecond pulsed electric fields (nsPEFs).
Med Oncol. 2017 Feb;34(2):24.
170.Wang B, Zhao XH.
Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116cells.
Oncol Rep. 2017 Feb;37(2):1132-1140.
171.Zhang A, Sheng Y, Zou M.
Antiproliferative activity of Alisol B in MDA-MB-231 cells is mediated by apoptosis, dysregulation ofmitochondrial functions, cell cycle arrest and generation of reactive oxygen species. 
Biomed Pharmacother. 2017 Mar;87:110-117.
172.Tong J, Mo QG, Ma BX, Ge LL, Zhou G, Wang YW.
The protective effects of Cichorium glandulosum seed and cynarin against cyclophosphamide and itsmetabolite acrolein-induced hepatotoxicity in vivo and in vitro. 
Food Funct. 2017 Jan 25;8(1):209-219.
173.Xue F, Shi C, Chen Q, Hang W, Xia L, Wu Y, Tao SZ, Zhou J, Shi A, Chen J.
Melatonin Mediates Protective Effects against Kainic Acid-Induced Neuronal Death through Safeguarding ER Stress and Mitochondrial Disturbance.
Front Mol Neurosci. 2017 Feb 28;10:49.
174.Su S, Zhu X, Lin L, Chen X, Wang Y, Zi J, Dong Y, Xie Y, Zhu Y, Zhang J, Zhu J, Xu D, Xu N, Lou X, Liu S.
Lowering Endogenous Cathepsin D Abundance Results in Reactive Oxygen SpeciesAccumulation and Cell Senescence.
Mol Cell Proteomics. 2017 Jul;16(7):1217-1232.
175.Qie X, Wen D, Guo H, Xu G, Liu S, Shen Q, Liu Y, Zhang W, Cong B, Ma C.
Endoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood-Brain BarrierDamage.
Front Pharmacol. 2017 Sep 14;8:639.
176.Xu D, Chen L, Chen X, Wen Y, Yu C, Yao J, Wu H, Wang X, Xia Q, Kong X.
The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy.
Cell Death Dis. 2017 Aug 10;8(8):e2983.
177.Huang HL, Shi YP, He HJ, Wang YH, Chen T, Yang LW, Yang T, Chen J, Cao J, Yao WM, Liu G.
MiR-4673 Modulates Paclitaxel-Induced Oxidative Stress and Loss of Mitochondrial MembranePotential by Targeting 8-Oxoguanine-DNA Glycosylase-1.
Cell Physiol Biochem. 2017;42(3):889-900.
178.Tian F, Wu CL, Yu BL, Liu L, Hu JR.
Apolipoprotein O expression in mouse liver enhances hepatic lipid accumulation by impairingmitochondrial function.
Biochem Biophys Res Commun. 2017 Sep 9;491(1):8-14.
179.Hu CH, Zhuang XJ, Wei YM, Zhang M, Lu SS, Lu YQ, Yang XG, Lu KH.
Comparison of Mitochondrial Function in Boar and Bull Spermatozoa ThroughoutCryopreservation Based on JC-1 Staining.
Cryo Letters. 2017 Jan/Feb;38(1):75-79.
180.Zhang A, Sheng Y, Zou M.
Antiproliferative activity of Alisol B in MDA-MB-231 cells is mediated by apoptosis, dysregulation of mitochondrial functions, cell cycle arrest and generation of reactive oxygen species.
Biomed Pharmacother. 2017 Mar;87:110-117.
181.Zhong Y, Jin C, Gan J, Wang X, Shi Z, Xia X, Peng X.
Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediatedmitochondrial dysfunction and caspase signal pathway.
Toxicon. 2017 Oct;137:106-113.
182.Feng Y, Wang Y, Jiang C, Fang Z, Zhang Z, Lin X, Sun L, Jiang W.
Nicotinamide induces mitochondrial-mediated apoptosis through oxidative stress in humancervical cancer HeLa cells.
Life Sci. 2017 Jul 15;181:62-69.
183.Wang T, Gao YY, Chen L, Nie ZW, Cheng W, Liu X, Schatten H4, Zhang X, Miao YL.
Melatonin prevents postovulatory oocyte aging and promotes subsequent embryonicdevelopment in the pig.
Aging (Albany NY). 2017 Jun 26;9(6):1552-1564.
184.You P, Wu H, Deng M, Peng J, Li F, Yang Y.
Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 viamitochondrial pathway and PI3K/AKT/mTOR inactivation.
Biomed Pharmacother. 2017 Dec 28;98:619-625.
185.Yang X, Tang S, Li D, Yu X, Wang F, Xiao X.
DIDS inhibits overexpression BAK1-induced mitochondrial apoptosis throughGSK3β/β-catenin signaling pathway.
J Cell Physiol. 2017 Dec 12.
186.Mehmood T, Maryam A, Tian X, Khan M, Ma T.
Santamarine Inhibits NF-кBand STAT3 Activation and Induces Apoptosis in HepG2 Liver CancerCells via Oxidative Stress.
J Cancer. 2017 Oct 17;8(18):3707-3717.
187.Wang P, Gao YM, Sun X, Guo N, Li J, Wang W, Yao LP, Fu YJ.
Hepatoprotective effect of 2'-O-galloylhyperin against oxidative stress-induced liver damage through induction of Nrf2/ARE-mediated antioxidant pathway.
Food Chem Toxicol. 2017 Apr;102:129-142.
188.Shan M, Qin J, Jin F, Han X, Guan H, Li X, Zhang J, Zhang H, Wang Y.
Autophagy suppresses isoprenaline-induced M2 macrophage polarization via the ROS/ERK and mTOR signaling pathway.
Free Radic Biol Med. 2017 Sep;110:432-443.
189.He Z, Pu L, Yuan C, Jia M, Wang J.
Nutrition deficiency promotes apoptosis of cartilage endplate stem cells ina caspase-independent manner partially through upregulating BNIP3.
Acta Biochim Biophys Sin (Shanghai). 2017 Jan;49(1):25-32.
190.Chen W, Liu Y, Zhang L, Gu X, Liu G, Shahid M, Gao J, Ali T, Han B.
Nocardia cyriacigeogica from Bovine Mastitis Induced In vitro Apoptosis of Bovine MammaryEpithelial Cells via Activation of Mitochondrial-Caspase Pathway.
Front Cell Infect Microbiol. 2017 May 18;7:194.
191.An J, Zhang Y, He J, Zang Z, Zhou Z, Pei X, Zheng X, Zhang W, Yang H, Li S.
Lactate dehydrogenase A promotes the invasion and proliferation of pituitary adenoma.
Sci Rep. 2017 Jul 5;7(1):4734.
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