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 Caspase 3 活性检测试剂盒

  产品编号C1115
  产品包装: 20次
  产品价格: 512.00元
产品编号 产品名称 产品包装 产品价格
C1115 Caspase 3 活性检测试剂盒 20次 512.00元

      Caspase 3 活性检测试剂盒(Caspase 3 Activity Assay Kit)是采用分光光度法检测细胞或组织裂解液中caspase 3酶活性或纯化的caspase 3酶活性的试剂盒。
      Caspase(Cysteine-requiring Aspartate Protease)是一个在细胞凋亡过程中起重要作用的蛋白酶家族。Caspase 3也称
CPP32、Yama或apopain,有时被写作caspase-3或caspase 3,属于caspase家族的CED-3亚家族(CED-3 subfamily),是细胞凋亡过程中的一个关键酶。Caspase 3是哺乳动物细胞中研究最多的一个caspase。Caspase 3可以剪切procaspase 3、6、7和9,并可以直接特异性剪切许多caspase底物,包括PARP(poly(ADP-ribose)polymerase),ICAD(Inhibitor of caspase-activated deoxyribonuclease),gelsolin和fodrin等。这些由caspase 3介导的蛋白剪切是细胞凋亡分子机制的重要组成部分。另外,caspase 3在细胞核凋亡过程中也起到了关键作用,包括染色质固缩(chromatin condensation),DNA片段化(DNA fragmentation)等。同时caspase 3对细胞起泡(cell blebbing)也起到关键作用。
      本Caspase 3 活性检测试剂盒是基于caspase 3可以催化底物Ac-DEVD-pNA(acetyl-Asp-Glu-Val-Asp p-nitroanilide)产生黄色的pNA(p-nitroaniline),从而可以通过测定吸光度来检测caspase 3的活性。pNA在405nm附近有强吸收。
      试剂盒中提供了caspase 3催化产生的黄色产物pNA,可以作为定量caspase 3酶活性的标准品。
      本试剂盒用酶标仪检测或容量不超过100μl的分光光度检测杯检测时,除标准曲线外可以检测20个样品。
包装清单:

产品编号 产品名称 包装
C1115-1 裂解液 8ml
C1115-2 检测缓冲液 8ml
C1115-3 Ac-DEVD-pNA(2mM) 200μl
C1115-4 pNA(10mM) 200μl
说明书 1份

保存条件:
      -20℃保存,Ac-DEVD-pNA和pNA需避光保存。
注意事项:
      须自备可以测定A405或A400的酶标仪或容量不超过100μl的分光光度检测杯及相应分光光度计。优先考虑测定A405,如有困难可以测定A400。
      Ac-YVAD-pNA需尽量避免反复冻融,请注意适当分装。
      测定蛋白浓度需Bradford蛋白浓度测定试剂盒(P0006),可向碧云天订购。建议样品用水稀释1倍后再用Bradford法测定蛋白浓度,以降低DTT对蛋白浓度测定的干扰。
      有文献报道少数类型的细胞凋亡检测不到caspase 3的激活。 
      pNA(中文名为4-硝基苯胺)对人体有毒,操作时请特别小心,并注意有效防护以避免直接接触人体或吸入体内。pNA(10mM)在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内,可以20-25℃水浴温育片刻至全部融解后使用。
      本试剂盒的裂解液可以和碧云天生产的其它caspase活性检测试剂盒的裂解液通用,即本试剂盒裂解液制备的蛋白样品可以用于碧云天其它caspase活性检测试剂盒的检测。
      本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
      为了您的安全和健康,请穿实验服并戴一次性手套操作。 

使用说明:
1.准备工作:
a.裂解液溶解后混匀并置于冰浴上备用。
b.检测缓冲液溶解后混匀并置于冰浴上备用。
2.测定pNA标准曲线:
a.标准品稀释液的配制:按照每0.9ml检测缓冲液加入0.1ml裂解液的比例配制适量的标准品稀释液。
b.把试剂盒提供的pNA (10mM)用标准品稀释液稀释为0、10、20、50、100和200μM,作为标准品。
c.每个浓度取100μl用酶标仪进行检测,或取适当量用容量不超过100μl的分光光度检测杯进行检测,测定A405。
d.每一个标准品的A405减去不含pNA的空白对照的A405计算出实际的因pNA而导致的吸光度,并制作出pNA浓度相对于A405的标准曲线。pNA标准曲线可以参考图1,在0-200μM范围内存在良好的线性关系。


图1.pNA标准曲线。实测数据可能因实验条件、检测仪器等的不同而存在差异,图中数据仅供参考。

3.样品的收集:
a.对于悬浮细胞:把没有诱导凋亡的对照样品和诱导凋亡的样品,600g 4℃离心5分钟收集细胞,小心吸除上清,同时确保尽量没有细胞被吸除,PBS洗涤一次。同前吸尽上清后,按照每200万细胞加入100微升裂解液的比例加入裂解液,重悬沉淀,冰浴裂解15分钟。下转步骤3d。
b.对于贴壁细胞:吸取细胞培养液,备用。用胰酶消化贴壁细胞,并收集至备用的细胞培养液中。600g 4℃离心5分钟收集细胞,小心吸除上清,同时确保尽量没有细胞被吸除,PBS洗涤一次。同前吸尽上清后,按照每200万细胞加入100微升裂解液的比例加入裂解液,重悬沉淀,冰浴裂解15分钟。下转步骤3d。
c.对于组织样品:按照每3-10mg组织加入100微升裂解液的比例加入裂解液,在冰浴上用玻璃匀浆器匀浆。然后把匀浆液转移到1.5ml离心管中,冰浴再裂解5分钟。
d.4℃ 16,000-20,000g离心10-15分钟。
e.把上清转移到冰浴预冷的离心管中。
f.立即测定caspase 3的酶活性或-70℃保存样品。同时可以取少量样品用Bradford法测定蛋白浓度,尽量使蛋白浓度达到1-3mg/ml,相当于每10微升待测样品中至少含有10-30μg蛋白。如果细胞较小,可以适当增加细胞的用量。
4.Caspase 3酶活性的检测:
a.取出适量的Ac-DEVD-pNA(2mM),置于冰浴上备用。
b.如下设置反应体系:

空白对照 样品
检测缓冲液 40μl 40μl
待测样品 0μl 50μl
裂解液 50μl 0μl
Ac-DEVD-pNA(2mM) 10μl 10μl
总体积 100μl 100μl

注意:在设置反应体系时先加检测缓冲液,再加待测样品,适当混匀,注意避免在混匀时产生气泡。随后再加入10μl Ac-DEVD-pNA(2mM)。
c.加入Ac-DEVD-pNA(2mM)后混匀,注意避免在混匀时产生气泡。37℃孵育60-120分钟。发现颜色变化比较明显时即可测定A405。如果颜色变化不明显,可以适当延长孵育时间,甚至可以孵育过夜。
d.样品的A405扣除空白对照的A405,即为样品中caspase 3催化产生的pNA产生的吸光度。通过同步骤1中获得的标准曲线的对比就可以计算出样品中催化产生了多少量的pNA。
e.参考Chemicon公司的caspase 3酶活力单位的定义:One unit is the amount of enzyme that will cleave 1.0nmol of the colorimetric substrate Ac-DEVD-pNA per hour at 37℃ under saturated substrate concentrations。即一个酶活力单位定义为当底物饱和时,在37℃一个小时内可以剪切1nmol Ac-DEVD-pNA产生1nmol pNA的caspase 3的酶量。这样就可以计算出样品中含有多少个酶活力单位的caspase 3。说明:在本试剂盒的检测体系中,底物的起始浓度为 0.2mM,此时底物是饱和的,对于许多样品而言在37℃孵育2个小时以内底物都是饱和的;对于样品中caspase 3酶活力特别高的情况,须用裂解液适当稀释样品后再进行测定。
f.用Bradford法检测待测样品中的蛋白浓度(由于裂解液中含有较高浓度的DTT,不适合采用BCA法进行蛋白浓度测定)。这样就可以计算出一个样品单位重量蛋白中所含的caspase 3的酶活力单位。
常见问题:
1.测定出的A405过低:
A.样品中蛋白含量太低,裂解样品时需设法使样品中的蛋白浓度至少达到1-3mg/ml。
B.样品中激活的caspase水平很低。首先确认凋亡现象是否明显,如果凋亡比较明显并且确认该caspase是可以被激活的,可以适当调节诱导细胞凋亡的时间,希望能找到一个caspase激活比较强的时间点,这样就可以检测出该caspase的激活。可以作一时间曲线,例如诱导凋亡0、2、4、8、16和24小时,或0、1、2、4、8和16小时,或0、1、2、4、6和8小时等。具体的诱导凋亡时间需根据具体情况而定。
2.测定出的A405过高或者样品量不足:
测定出来的A405读数过高时,可以参考下表的反应体系适当减少样品的用量;样品量不足时也可以参考下表减少样品的用量。

空白对照 样品
检测缓冲液 40μl 40μl
待测样品 0μl xμl
裂解液 50μl (50-x)μl
Ac-DEVD-pNA(2mM) 10μl 10μl
总体积 100μl 100μl

说明:其中x不超过50,其余检测方法同上面的使用说明所述。

相关产品:

产品编号 产品名称 包装
C1101 Caspase 1 活性检测试剂盒 20次
C1102 Caspase 1 活性检测试剂盒 100次
C1107 Caspase 2 活性检测试剂盒 20次
C1108 Caspase 2 活性检测试剂盒 100次
C1115 Caspase 3 活性检测试剂盒 20次
C1116 Caspase 3 活性检测试剂盒 100次
C1121 Caspase 4 活性检测试剂盒 20次
C1122 Caspase 4 活性检测试剂盒 100次
C1135 Caspase 6 活性检测试剂盒 20次
C1136 Caspase 6 活性检测试剂盒 100次
C1151 Caspase 8 活性检测试剂盒 20次
C1152 Caspase 8 活性检测试剂盒 100次
C1157 Caspase 9 活性检测试剂盒 20次
C1158 Caspase 9 活性检测试剂盒 100次
P0006 Bradford蛋白浓度测定试剂盒 1000次

相关产品请点击如下按钮:

使用本产品的文献:
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Cytoprotective effects of selenium on cadmium-induced LLC-PK1 cells apoptosis by activating JNK pathway.
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Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus).
Aquatic Toxicology. 2007 May; 82(2): 135-143.
3. Wang Q, Luo W, Zhang W, Dai Z, Chen Y, Chen J.
Iron supplementation protects against lead-induced apoptosis through MAPK pathway in weanling rat cortex.
Neurotoxicology. 2007 Jul;28(4):850-9.
4. Li J, Xia X, Ke Y, Nie H, Smith MA, Zhu X.
Trichosanthin induced apoptosis in HL-60 cells via mitochondrial and endoplasmic reticulum stress signaling pathways.
Biochim Biophys Acta. 2007 Aug;1770(8):1169-80.
5. Qian YF, Yao WB, Wang H, Gao XD.
The Mechanism of Kaixin San Inhibiting Apoptosis in Hydrogen Peroxide2induced PC12 Cells.
Chin J Nat Med. 2007 Sep;5(5):379-84.
6. Zhao CQ, Liu D, Li H, Jiang LS, Dai LY.
Interleukin-1beta enhances the effect of serum deprivation on rat annular cell apoptosis.
Apoptosis. 2007 Dec;12(12):2155-61.
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Effects of Berberine on the Growth of Hepatocellular Carcinoma Cell lines.
Medical Journal of Wuhan University.2008 Jan;29(1):102-105.
8. Qian YF, Wang H, Yao WB, Gao XD.
Aqueous extract of the Chinese medicine, Danggui-Shaoyao-San, inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivatingof caspase cascade.
Cell Biol Int. 2008 Feb;32(2):304-11.
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Ozone oxidative preconditioning inhibits inflammation and apoptosis in a rat model of renal ischemia/reperfusion injury.
Eur J Pharmacol. 2008 Mar 10;581(3):306-14.
10.Yang J, Wang J, Zhu S, Chen X, Wu H, Yang D, Zhang J.
C-reactive protein augments hypoxia-induced apoptosis through mitochondrion-dependent pathway in cardiac myocytes.
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20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells.
Eur J Pharmacol. 2008 Jun 24;588(1):9-17.
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Salidroside inhibits H2O2-induced apoptosis in PC12 cells by preventing cytochrome c release and inactivating of caspase cascade.
Acta Biochim Biophys Sin (Shanghai). 2008 Sep;40(9):796-802.
14.Yang Z, Mo X, Gong Q, Pan Q, Yang X, Cai W, Li C, Ma JX, He Y, Gao G.
Critical effect of VEGF in the process of endothelial cell apoptosis induced by high glucose.
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15-HETE suppresses K(+) channel activity and inhibits apoptosis in pulmonary artery smooth muscle cells.
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Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice.
Phytomedicine. 2010;17(10):811-9.
33.Bai F, Sun B, Woo NY, Zhang XH.
Vibrio harveyi hemolysin induces ultrastructural changes and apoptosis in flounder (Paralichthys olivaceus) cells.
Biochem Biophys Res Commun. 2010;395(1):70-5.
34.Wang GF, Guo YW, Feng B, Li L, Huang CG, Jiao BH.
Tanghinigenin from seeds of Cerbera manghas L. induces apoptosis in human promyelocytic leukemia HL-60 cells.
Environmental Toxicology and Pharmacology. 2010 Jul;30(1):31-6.
35.Zhu JR, Tao YF, Lou S, Wu ZM.
Protective effects of ginsenoside Rb(3) on oxygen and glucose deprivation-induced ischemic injury in PC12 cells.
Acta Pharmacol Sin. 2010;31(3):273-80.
36.Gong X, Luo FL, Zhang L, Li HZ, Wu MJ, Li XH, Wang B, Hu N, Wang CD, Yang JQ, Wan JY.
Tetrandrine attenuates lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice.
Int Immunopharmacol. 2010;10(3):357-63.
37.Wang W, Xu J, Li L, Wang P, Ji X, Ai H, Zhang L, Li L.
Neuroprotective effect of morroniside on focal cerebral ischemia in rats.
Brain Res Bull. 2010;83(5):196-201.
38.Shi L, Chen J, Yang J, Pan T, Zhang S, Wang Z.
MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity.
Brain Res. 2010;1352:255-64.
39.Wang J, Li X, Liu Y, Zhao X.
Salt stress induces programmed cell death in Thellungiella halophila suspension-culturedcells.
J Plant Physiol. 2010;167(14):1145-51.
40.Wang CJ, Hu CP, Xu KP, Yuan Q, Li FS, Zou H, Tan GS, Li YJ.
Protective effect of selaginellin on glutamate-induced cytotoxicity and apoptosis in differentiated PC12 cells.
Naunyn Schmiedebergs Arch Pharmacol. 2010;381(1):73-81.
41.Tang KF, Song GB, Shi YS, Yuan L, Li YH.
Dicer knockdown induces fibronectin-1 expression in HEK293T cells via induction of Egr1.
Biochim Biophys Acta. 2010;1800(3):380-4.
42.Xu AH, Hu ZM, Qu JB, Liu SM, Syed AK, Yuan HQ, Lou HX.
Cyclic bisbibenzyls induce growth arrest and apoptosis of human prostate cancer PC3 cells.
Acta Pharmacol Sin. 2010;31(5):609-15.
43.Yang Y, Xing D, Zhou F, Chen Q.
Mitochondrial autophagy protects against heat shock-induced apoptosis through reducing cytosolic cytochrome c release and downstream caspase-3 activation.
Biochem Biophys Res Commun. 2010;395(2):190-5.
44.Ma H, Quan F, Chen D, Zhang B, Zhang Y.
Alterations in mitochondrial function and spermatozoal motility in goat spermatozoa following incubation with a human lysozyme plasmid.
Anim Reprod Sci. 2010;121(1-2):106-14.
45.Wang Y, Gao J, Zhang D, Zhang J, Ma J, Jiang H.
New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis.
J Hepatol. 2010;53(1):132-44.
46.Shi YQ, Wang YP, Song Y, Li HW, Liu CJ, Wu ZG, Yang KD.
p,p'-DDE induces testicular apoptosis in prepubertal rats via the Fas/FasL pathway.
Toxicol Lett. 2010;193(1):79-85.
47.SJi YB, Qu ZY, Zou X.
Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway.
Exp Toxicol Pathol. 2011 Jan; 63(1–2):69–78.
48.Zhang Y, Li RJ, Ying X, Tian W, Yao HJ, Men Y, Yu Y, Zhang L, Ju RJ, Wang XX, Zhou J, Chen JX, Li N, Lu WL.
Targeting therapy with mitosomal daunorubicin plus amlodipine has the potential tocircumventintrinsic resistant breast cancer.
Mol Pharm. 2011 Feb 7;8(1):162-75.
49.Abdou MA, He Q, Wen D, Zyaan O, Wang J, Xu J, Baumann AA, Joseph J, Wilson TG, Li S,Wang J.
Drosophila Met and Gce are partially redundant in transducing juvenile hormone action.
Insect Biochem Mol Biol. 2011 Dec;41(12):938-45.
50.Qu M, Zhou Z, Chen C, Li M, Pei L, Chu F, Yang J, Wang Y, Li L, Liu C, Zhang L, Zhang G,Yu Z, Wang D.
Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rathippocampalneurons by inhibiting the mitochondrial apoptotic pathway.
Neurochem Int. 2011 Dec;59(8):1095-103.
51.Shi X, Gu A, Ji G, Li Y, Di J, Jin J, Hu F, Long Y, Xia Y, Lu C, Song L, Wang S, Wang X.
Developmental toxicity of cypermethrin in embryo-larval stages of zebrafish.
Chemosphere. 2011 Oct;85(6):1010-6.
52.Chen X, Ran ZH, Tong JL, Nie F, Zhu MM, Xu XT, Xiao SD.
RNA interference (RNAi) of Ufd1 protein can sensitize a hydroxycamptothecin-resistantcoloncancer cell line SW1116/HCPT to hydroxycamptothecin.
J Dig Dis. 2011 Apr;12(2):110-6.
53.Huang B, Cao K, Li X, Guo S, Mao X, Wang Z, Zhuang J, Pan J, Mo C, Chen J, Qiu S.
The expression and role of protein kinase C (PKC) epsilon in clear cell renal cellcarcinoma.
J Exp Clin Cancer Res. 2011 Sep 28;30:88.
54.Tan C, Zhang LY, Chen H, Xiao L, Liu XP, Zhang JX.
Overexpression of the human ubiquitin E3 ligase CUL4A alleviates hypoxia-reoxygenationinjuryin pheochromocytoma (PC12) cells.
Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):403-8.
55.Du K, Zheng Q, Zhou M, Zhu L, Ai B, Zhou L.
Chlamydial antiapoptotic activity involves activation of the Raf/MEK/ERK survival pathway.
Curr Microbiol. 2011 Oct;63(4):341-6.
56.Xu Y, Zheng H, Kang JS, Zhang L, Su J, Li HY, Sun LK.
5-Nitro-2-(3-phenylpropylamino) benzoic acid induced drug resistance to cisplatin inhumanerythroleukemia cell lines.
Anat Rec (Hoboken). 2011 Jun;294(6):945-52.
57.Feng Q, Cao HL, Xu W, Li XR, Ren YQ, Du LF.
Apoptosis induced by genipin in human leukemia K562 cells: involvement of c-Jun N-terminal kinase in G2/M arrest.
Acta Pharmacol Sin. 2011 Apr;32(4):519-27.
58.Lou H, Fan P, Perez RG, Lou H.
Neuroprotective effects of linarin through activation of the PI3K/Akt pathway in amyloid-β-induced neuronal cell death.
Bioorg Med Chem. 2011 Jul 1;19(13):4021-7.
59.Zhang W, Liu J, Sun R, Zhao L, Du J, Ruan C, Dai K.
Calpain activator dibucaine induces platelet apoptosis.
Int J Mol Sci. 2011;12(4):2125-37.
60.Chen H, Mei L, Zhou L, Shen X, Guo C, Zheng Y, Zhu H, Zhu Y, Huang L.
PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth invitroand in xenografts.
J Neurooncol. 2011 Aug;104(1):155-67.
61.Yu G, Li Y, Tian Q, Liu R, Wang Q, Wang JZ, Wang X.
Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation inHEK293cells.
J Alzheimers Dis. 2011;24(3):525-35
62.Tian LL, Yue W, Zhu F, Li S, Li W.
Human mesenchymal stem cells play a dual role on tumor cell growth in vitro and in vivo.
J Cell Physiol. 2011 Jul;226(7):1860-7.
63.Xu B, Xu Z, Xia T, He P, Gao P, He W, Zhang M, Guo L, Niu Q, Wang A.
Effects of the Fas/Fas-L pathway on fluoride-induced apoptosis in SH-SY5Y cells.
Environ Toxicol. 2011 Feb;26(1):86-92.
64.Li M, Ding Y, Mu Y, Ao J, Chen X
Molecular cloning and characterization of caspase-3 in large yellow croaker(Pseudosciaenacrocea).
Fish Shellfish Immunol. 2011 Mar;30(3):910-6.
65.Wang K, Cheng L, Liang Y, Liu D, Li K, Wang P.
Adenovirus-mediated delivery of shRNA against bFGF mRNA suppresses growth of culturedhuman primary prostatic stromal cells.
Mol Biol Rep. 2011 Feb;38(2):971-6.
66.Wu Y, Xia ZY, Dou J, Zhang L, Xu JJ, Zhao B, Lei S, Liu HM.
Protective effect of ginsenoside Rb1 against myocardial ischemia/reperfusion injuryinstreptozotocin-induced diabetic rats.
Mol Biol Rep. 2011 Oct;38(7):4327-35.
67.Tong JS, Zhang QH, Huang X, Fu XQ, Qi ST, Wang YP, Hou Y, Sheng J, Sun QY.
Icaritin causes sustained ERK1/2 activation and induces apoptosis in human endometrialcancercells.
PLoS One. 2011 Mar 8;6(3):e16781.
68.Li J, Cheng Y, Qu W, Sun Y, Wang Z, Wang H, Tian B.
Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activationof p53 andinhibition of NF-kappa B pathways in bladder cancer cells.
Basic Clin Pharmacol Toxicol. 2011 Feb;108(2):84-93.
69.Gong L, Liu FQ, Wang J, Wang XP, Hou XG, Sun Y, Qin WD, Wei SJ, Zhang Y, Chen L, Zhang MX.
Hyperglycemia induces apoptosis of pancreatic islet endothelial cells via reactivenitrogenspecies-mediated Jun N-terminal kinase activation.
Biochim Biophys Acta. 2011 Jun;1813(6):1211-9.
70.Li P, Yin Y, Yu Q, Yang Q.
Lactobacillus acidophilus S-layer protein-mediated inhibition of Salmonella-inducedapoptosis inCaco-2 cells.
Biochem Biophys Res Commun. 2011 May 27;409(1):142-7.
71.Zhu S, Jin J, Wang Y, Ouyang Z, Xi C, Li J, Qiu Y, Wan J, Huang M, Huang Z.
The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin inHK-2 cells.
Food Chem Toxicol. 2012 Mar;50(3-4):1149-58.
72.Li ZL, Liu JC, Hu J, Li XQ, Wang SW, Yi DH, Zhao MG.
Protective effects of hyperoside against human umbilical vein endothelial cell damageinduced byhydrogen peroxide.
J Ethnopharmacol. 2012 Jan 31;139(2):388-94.
73.Nie X, Song S, Zhang L, Qiu Z, Shi S, Liu Y, Yao L, Zhu D.
15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cellsfromapoptosis via inducible nitric oxide synthase (iNOS) pathway.
Prostaglandins Other Lipid Mediat. 2012 Jan;97(1-2):50-9.
74.Arockiaraj J, Easwvaran S, Vanaraja P, Singh A, Othman RY, Bhassu S.
Effect of infectious hypodermal and haematopoietic necrosis virus (IHHNV) infection oncaspase3c expression and activity in freshwater prawn Macrobrachium rosenbergii.
Fish Shellfish Immunol. 2012 Jan;32(1):161-9.
75.Zhao D, Lin F, Wu X, Zhao Q, Zhao B, Lin P, Zhang Y, Yu X.
Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation inhormone-refractory prostate cancer DU145 cells.
Toxicol In Vitro. 2012 Jun;26(4):595-602.
76.Zhang W, Zhao L, Liu J, Du J, Wang Z, Ruan C, Dai K.
Cisplatin induces platelet apoptosis through the ERK signaling pathway.
Thromb Res.2012 Jul;130(1):81-91.
77.Lv M, Zhang Y, Liang L, Wei M, Hu W, Li X, Huang Q.
Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line.
Nanoscale.2012 Jul 7;4(13):3861-6.
78.Lv L, Jiang SS, Xu J, Gong JB, Cheng Y.
Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role ofendothelial nitric oxide synthase.
Clin Exp Pharmacol Physiol.2012 Jan;39(1):20-7.
79.Jia Y, Li Y, Du S, Huang K.
Involvement of MsrB1 in the regulation of redox balance and inhibition of peroxynitrite-inducedapoptosis in human lens epithelial cells.
Exp Eye Res. 2012 Jul;100:7-16.
80.Ma J, Zhang L, Han W, Shen T, Ma C, Liu Y, Nie X, Liu M, Ran Y, Zhu D.
Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesisinduced by EETin pulmonary artery endothelial cells.
J Lipid Res.2012 Jun;53(6):1093-105.
81.Wang YW, Wang SJ, Zhou YN, Pan SH, Sun B.
Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κBandnuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo.
J Cancer Res Clin Oncol. 2012 May;138(5):785-97.
82.Tang J, Guo YS, Zhang Y, Yu XL, Li L, Huang W, Li Y, Chen B, Jiang JL, Chen ZN.
CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing thetranscription ofBip in hepatocellular carcinoma.
Cell Death Differ.2012 Nov;19(11):1779-90.
83.Jiang Y, Lv H, Liao M, Xu X, Huang S, Tan H, Peng T, Zhang Y, Li H.
GRP78 counteracts cell death and protein aggregation caused by mutant huntingtinproteins.
Neurosci Lett. 2012 May 16;516(2):182-7.
84.Ye Z, Guo Q, Xia P, Wang N, Wang E, Yuan Y.
Sevoflurane postconditioning involves an up-regulation of HIF-1α and HO-1 expressionviaPI3K/Akt pathway in a rat model of focal cerebral ischemia.
Brain Res.2012 Jun 29;1463:63-74.
85.Liao XH, Chen GT, Li Y, Zhang L, Liu Q, Sun H, Guo H.
Augmenter of liver regeneration attenuates tubular cell apoptosis in acute kidney injuryin rats: thepossible mechanisms.
Ren Fail. 2012;34(5):590-9.
86.Chi J, Zhu Y, Fu Y, Liu Y, Zhang X, Han L, Yin X, Zhao D.
Cyclosporin A induces apoptosis in H9c2 cardiomyoblast cells through calcium-sensingreceptor-mediated activation of the ERK MAPK and p38 MAPK pathways.
Mol Cell Biochem. 2012 Aug;367(1-2):227-36.
87.Zhang S, Wan Y, Pan T, Gu X, Qian C, Sun G, Sun L, Xiang Y, Wang Z, Shi L.
MicroRNA-21 Inhibitor Sensitizes Human Glioblastoma U251 Stem Cells to ChemotherapeuticDrugTemozolomide.
J Mol Neurosci.2012 Jun;47(2):346-56.
88.Liu Q, Xiao L, Yuan D, Shi X, Li P.
Silencing of the integrin-linked kinase gene induces the apoptosis in ovarian carcinoma.
J Recept Signal Transduct Res.2012 Apr;32(2):120-7.
89.Zhu S, Wang Y, Jin J, Guan C, Li M, Xi C, Ouyang Z, Chen M, Qiu Y, Huang M, Huang Z.
Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in humanrenalproximal tubular epithelial cells.
Toxicol In Vitro. 2012 Aug;26(5):663-71.
90.Gao Q, Qi L, Wu T, Wang J.
An important role of interleukin-10 in counteracting excessive immune response in HT-29cellsexposed to Clostridium butyricum.
BMC Microbiol. 2012 Jun 8;12(1):100.
91.Ren Y, Cai Y, Jia D.
Comparative Antiapoptotic Effects of KB-R7943 and Ischemic Postconditioning DuringMyocardialIschemia Reperfusion.
Cell Biochem Biophys. 2012 Nov;64(2):137-45.
92.Zhang L, Ma J, Shen T, Wang S, Ma C, Liu Y, Ran Y, Wang L, Liu L, Zhu D.
Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition.
Cell Signal.2012 Oct;24(10):1931-9.
93.Xu HL, Yu XF, Qu SC, Qu XR, Jiang YF, Sui da Y.
Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis inhumanleukemia cell HL-60 through a reactive oxygen species-dependent mechanism.
Food Chem Toxicol. 2012 Mar;50(3-4):590-6.
94.Qian Y, Guan T, Huang M, Cao L, Li Y, Cheng H, Jin H, Yu D.
Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependentapoptosis pathways and reactive oxygen induced-NF-κB activationin a cerebral ischemia mouse model.
Neurochem Int. 2012 Jun;60(8):759-67.
95.Zhu X, Li Y, Luo X, Fei J.
Inhibition of small GTPase RalA regulates growth and arsenic-induced apoptosis inchronicmyeloid leukemia (CML) cells.
Cell Signal. 2012 Jun;24(6):1134-40.
96.Hu W, Chen FH, Yuan FL, Zhang TY, Wu FR, Rong C, Jiang S, Tang J, Zhang CC, Lin MY.
Blockade of acid-sensing ion channels protects articular chondrocytes from acid-inducedapoptoticinjury.
Inflamm Res.2012 Apr;61(4):327-35.
97.Zhou Z, Wan Y, Zhang Y, Wang Z, Jia R, Fan Y, Nie H, Ying S, Huang P, Wang F.
Follicular development and expression of nuclear respiratory factor-1 and peroxisomeproliferator-activated receptor γ coactivator-1 alpha in ovaries of fetal and neonataldoelings.
J Anim Sci.2012 Nov;90(11):3752-61.
98.Hu R, Zhou P, Peng YB, Xu X, Ma J, Liu Q, Zhang L, Wen XD, Qi LW, Gao N, Li P.
6-Shogaol Induces Apoptosis in Human Hepatocellular Carcinoma Cells and ExhibitsAnti-TumorActivity In Vivo through Endoplasmic Reticulum Stress.
PLoS One. 2012;7(6):e39664.
99.Li Y, Liu L, Niu Y, Feng J, Sun Y, Kong X, Chen Y, Chen X, Gan H, Cao S, Mei Q.
Modified apple polysaccharide prevents against tumorigenesis in a mouse model of colitis-associated colon cancer: role of galectin-3 and apoptosis in cancer prevention.
Eur J Nutr.2012 Feb;51(1):107-17.
100.Dan Zhu D, HeHJ, Hao LR, TangJ, CaoD
Aldosterone induces apoptosis via the Wnt signalling pathway
African Journal of Pharmacy and Pharmacology. 2012 May 22; 6(19): 1428-1434.
101.Gao W, Ji L, Li L, Cui G, Xu K, Li P, Tang B.
Bifunctional combined Au-Fe(2)O(3) nanoparticles for induction of cancer cell-specificapoptosis and real-time imaging.
Biomaterials.2012 May;33(14):3710-8.
102.Cheng J, Tang W, Su Z, Guo J, Tong L, Wei Q.
Calcineurin subunit B promotes TNF-alpha-induced apoptosis by binding to mitochondria and causing mitochondrial Ca2+ overload.
Cancer Lett. 2012 Aug 28;321(2):169-78.
103.Zhai FX, Liu XF, Fan RF, Long ZJ, Fang ZG, Lu Y, Zheng YJ, Lin DJ.
RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdRandTSA in leukaemia cell lines.
J Cancer Res Clin Oncol. 2012 Mar;138(3):439-49.
104.Chen HB, Zhou LZ, Mei L, Shi XJ, Wang XS, Li QL, Huang L.
Gambogenic acid-induced time- and dose-dependent growth inhibition and apoptosisinvolving Akt pathwayinactivation in U251 glioblastoma cells.
J Nat Med.2012 Jan;66(1):62-9.
105.Zhou YC, Liu B, Li YJ, Jing LL, Wen G, Tang J, Xu X, Lv ZP, Sun XG.
Effects of buyang huanwu decoction on ventricular remodeling and differential proteinprofile in a rat model ofmyocardial infarction.
Evid Based Complement Alternat Med. 2012;2012:385247.
106.Li Y, Wang H, Yang B, Yang J, Ruan X, Yang Y, Wakeland EK, Li Q, Fang X.
Influence of carbon monoxide on growth and apoptosis of human umbilical artery smoothmuscle cells and veinendothelial cells.
Int J Biol Sci. 2012;8(10):1431-46.
107.Guo C, Zeng X, Song J, Zhang M, Wang H, Xu X, Du F, Chen B.
A Soluble Receptor for Advanced Glycation End-Products Inhibits Hypoxia/Reoxygenation-Induced Apoptosis inRat Cardiomyocytes via theMitochondrial Pathway.
Int J Mol Sci. 2012;13(9):11923-40.
108.Zhang WF, Xu YY, Xu KP, Wu WH, Tan GS, Li YJ, Hu CP.
Inhibitory effect of selaginellin on high glucose-induced apoptosis in differentiatedPC12 cells: role of NADPHoxidase and LOX-1.
Eur J Pharmacol. 2012 Nov 5;694(1-3):60-8.
109.Liu J, Lu Y, Liang J.
A novel fluorescence derivatization method combined with HPLC for determining theactivities of endogenouscaspase.
Analyst.2012 Nov 7;137(21):5097-104.
110.Guo E, He Q, Liu S, Tian L, Sheng Z, Peng Q, Guan J, Shi M, Li K, Gilbert LI, Wang J, Cao Y, Li S.
MET is required for the maximal action of 20-hydroxyecdysone during Bombyx metamorphosis.
PLoS One.2012;7(12):e53256.
111.Xiao F, Zhang JS, Zhao JY, Wu D.
Regulation of Eaf2 in mouse lens cells apoptosis induced by ultraviolet radiation.
Int J Ophthalmol.2012;5(5):570-5.
112.Yuan XH, Lu CL, Yao N, An LS, Yang BQ, Zhang CL, Ma X.
Arsenic induced progesterone production in a caspase-3-dependent manner and changed redox status inpreovulatory granulosa cells.
J Cell Physiol.2012 Jan;227(1):194-203.
113.Bu TL, Jia YD, Lin JX, Mi YL, Zhang CQ.
Alleviative effect of quercetin on germ cells intoxicated by 3-methyl-4-nitrophenol from diesel exhaust particles.
J Zhejiang Univ Sci B.2012 Apr;13(4):318-26.
114.Yu W, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C.
Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats.
PLoS One. 2012 December 14; 7(12): e52013.
115.Wang J, Wang Q, Li J, Shen Q, Wang F, Wang L.
Cadmium induces hydrogen peroxide production and initiates hydrogen peroxide-dependentapoptosis in the gillof freshwater crab, Sinopotamon henanense.
Comp Biochem Physiol C Toxicol Pharmacol.2012 Nov;156(3-4):195-201.
116.Zha YY, Yang B, Tang ML, Guo QC, Chen JT, Wen LP, Wang M.
Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability.
Int J Nanomedicine.2012;7:3099-109.
117.Cao M, Tong Y, Lv Q, Chen X, Long Y, Jiang L, Wan J, Zhang Y, Zhang F, Tong N.
PPARδ Activation Rescues Pancreatic β-Cell Line INS-1E from Palmitate-InducedEndoplasmic Reticulum Stressthrough Enhanced Fatty Acid Oxidation.
PPAR Res.2012;2012:680684.
118.Liu Q, Peng YB, Qi LW, Cheng XL, Xu XJ, Liu LL, Liu EH, Li P.
The Cytotoxicity Mechanism of 6-Shogaol-Treated HeLa Human Cervical Cancer CellsRevealed by Label-FreeShotgun Proteomics and Bioinformatics Analysis.
Evid Based Complement Alternat Med.2012;2012:278652.
119.Yue R, Hu H, Yiu KH, Luo T, Zhou Z, Xu L, Zhang S, Li K, Yu Z.
Lycopene protects against hypoxia/reoxygenation-induced apoptosis by preventingmitochondrial dysfunction inprimary neonatal mouse cardiomyocytes.
PLoS One.2012;7(11):e50778.
120.Jia LQ, Yang GL, Ren L, Chen WN, Feng JY, Cao Y, Zhang L, Li XT, Lei P.
Tanshinone IIA reduces apoptosis induced by hydrogen peroxide in the human endothelium-derived EA.hy926cells.
J Ethnopharmacol.2012 Aug 30;143(1):100-8.
121.Ding GB, Liu HY, Lv YY, Liu XF, Guo Y, Sun CK, Xu L.
Enhanced in vitro antitumor efficacy and strong anti-cell-migration activity of a hydroxycamptothecin-encapsulated magnetic nanovehicle.
Chemistry.2012 Oct 29;18(44):14037-46.
122.Gong K, Chen C, Zhan Y, Chen Y, Huang Z, Li W.
Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellularcarcinoma.
J Biol Chem.2012 Oct 12;287(42):35576-88.
123.Huang P, Zhou ZR, Zheng MQ, Shi FX.
Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway in the duodenal mucosa of ratssubjected to waterimmersion and restraint stress.
Genet Mol Res.2012 Sep 19;11(4):4775-88.
124.Zhao L, Peng DQ, Zhang J, Song JQ, Teng X, Yu YR, Tang CS, Qi YF.
Extracellular signal-regulated kinase 1/2 activation is involved in intermedin1-53attenuating myocardial oxidativestress injury induced by ischemia/reperfusion.
Peptides.2012 Feb;33(2):329-35.
125.Liu J, Pang Y, Chen J, Huang P, Huang W, Zhu X, Yan D.
Hyperbranched polydiselenide as a self assembling broad spectrum anticancer agent.
Biomaterials.2012 Nov;33(31):7765-74.
126.eng Z, Yan H, Hu J, Zhang S, Peng P, Liu Q, Guo D.
Hepatitis C virus sensitizes host cells to TRAIL-induced apoptosis by up-regulating DR4and DR5 via a MEK1-dependent pathway.
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127.hao WH, Gou BD, Zhang TL, Wang K.
Lanthanum chloride bidirectionally influences calcification in bovine vascular smoothmuscle cells.
J Cell Biochem.2012 May;113(5):1776-86.
128.Guo W, Liu W, Hong S, Liu H, Qian C, Shen Y, Wu X, Sun Y, Xu Q.
Mitochondria-dependent apoptosis of con A-activated T lymphocytes induced by asiatic acid for preventingmurine fulminant hepatitis.
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129.Li JZ, Yu SY, Wu JH, Shao QR, Dong XM.
Paeoniflorin protects myocardial cell from doxorubicin-induced apoptosis throughinhibition of NADPH oxidase.
Can J Physiol Pharmacol. 2012 Dec;90(12):1569-75.
130.Wang H, Zhou X, Zhang Y, Zhu H, Zhao L, Fan L, Wang Y, Gang Y, Wu K, Liu Z, Fan D.
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FEBS J.2012 Oct;279(19):3652-64.
131.Zhang L, Ji Q, Ni ZH, Sun J.
Prohibitin induces apoptosis in BGC823 gastric cancer cells through the mitochondrialpathway.
Asian Pac J Cancer Prev.2012;13(8):3803-7.
132.Yang G, Zhou X, Wang J, Zhang W, Zheng H, Lu W, Yuan J.
MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway.
Food Chem Toxicol.2012 Jul;50(7):2424-31.
133.Ji Y, Ji C, Yue L, Xu H.
Saponins isolated from Asparagus induce apoptosis in human hepatoma cell line HepG2through a mitochondrial-mediated pathway.
Curr Oncol.2012 Jul;19(Suppl 2):eS1-9.
134.Ma EL, Zhao DM, Li YC, Cao H, Zhao QY, Li JC, Sun LX.
Activation of ATM-Chk2 by 16-dehydropregnenolone induces G1 phase arrest and apoptosisin HeLa cells.
J Asian Nat Prod Res.2012;14(9):817-25.
135.Zhou BR, Yin HB, Xu Y, Wu D, Zhang ZH, Yin ZQ, Permatasari F, Luo D.
Baicalin protects human skin fibroblasts from ultraviolet A radiation-induced oxidativedamage and apoptosis.
Free Radic Res.2012 Dec;46(12):1458-71.
136.Li H, Song Y, Zhang LJ, Li FF, Gu Y, Zhang J, Dong WP, Xue L, Zhang LY, Liu F, Wang J,Jiang LN, Ye J, Li Q.
Cell death-inducing DFF45-like effector b (Cideb) is present in pancreatic beta-cells and involved in palmitateinduced beta-cell apoptosis.
Diabetes Metab Res Rev.2012 Feb;28(2):145-55.
137.Ge XH, Zhu GJ, Geng DQ, Zhang ZJ, Liu CF.
Erythropoietin attenuates 6-hydroxydopamine-induced apoptosis via glycogen synthasekinase 3b-mediated mitochondrial translocation of Bax in PC12 cells.
Neurol Sci.2012 Dec;33(6):1249-56.
138.Lu B, Xu Y, Xu L, Cong X, Yin L, Li H, Peng J.
Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice.
Environ Toxicol Pharmacol.2012 Sep;34(2):127-35.
139.Zhang H, Shao D, Wu Y, Cai C, Hu C, Shou X, Dai B, Ye B, Wang M, Jia X.
Apoptotic responses of Carassius auratus lymphocytes to nodularin exposure in vitro.
Fish Shellfish Immunol.2012 Dec;33(6):1229-37.
140.Huang HC, Xu K, Jiang ZF.
Curcumin-mediated neuroprotection against amyloid-β-induced mitochondrial dysfunction involves the inhibitionof GSK-3β.
J Alzheimers Dis.2012;32(4):981-96.
141.Li XY, Jing CQ, Lei WL, Li J, Wang JJ.
Apoptosis caused by imidazolium-based ionic liquids in PC12 cells.
Ecotoxicol Environ Saf.2012 Sep;83:102-7.
142.Rong C, Chen FH, Jiang S, Hu W, Wu FR, Chen TY, Yuan FL.
Inhibition of acid-sensing ion channels by amiloride protects rat articular chondrocytesfrom acid-inducedapoptosis via a mitochondrial-mediated pathway.
Cell Biol Int.2012 Jul;36(7):635-41.
143.Chen XM, Liu J, Wang T, Shang J.
Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediatedpathways.
Toxicol In Vitro.2012 Aug;26(5):649-55.
144.Chen Y, Liu J, Yuan B, Cao C, Qin S, Cao X, Bian G, Wang Z, Jiang J.
Methylated actinomycin D, a novel actinomycin D analog induces apoptosis in HepG2 cellsthrough fas- andmitochondria-mediated pathways.
Mol Carcinog.2013 Dec;52(12):983-96.
145.Mao Z, Xia W, Wang J, Chen T, Zeng Q, Xu B, Li W, Chen X, Xu S.
Perfluorooctane sulfonate induces apoptosis in lung cancer A549 cells through reactiveoxygen species-mediated mitochondrion-dependent pathway.
J Appl Toxicol. 2013 Nov;33(11):1268–76.
146.Hu M, Xu L, Yin L, Qi Y, Li H, Xu Y, Han X, Peng J, Wan X.
Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor andmitochondrial pathways.
J Appl Toxicol. 2013 August; 33(8): 712–722.
147.Fang XY, Chen W, Fan JT, Song R, Wang L, Gu YH, Zeng GZ, Shen Y, Wu XF, Tan NH, Xu Q,
Sun Y.
Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis throughblocking PDK1-AKT interaction.
Toxicol Appl Pharmacol.2013 Feb 15;267(1):95-103.
148.Guo J, Zhang Y, Zeng L, Liu J, Liang J, Guo G.
Salvianic acid A protects L-02 cells against γ-irradiation-induced apoptosis via thescavenging of reactive oxygenspecies.
Environ Toxicol Pharmacol.2013 Jan;35(1):117-30.
149.Zhang M, Zhu R, Zhang M, Gao B, Sun D, Wang S.
High-energy pulse-electron-beam-induced molecular and cellular damage in Saccharomycescerevisiae.
Res Microbiol.2013 Feb-Mar;164(2):100-9.
150.Guo LD, Chen XJ, Hu YH, Yu ZJ, Wang D, Liu JZ.
Curcumin inhibits proliferation and induces apoptosis of human colorectal cancer cellsby activating themitochondria apoptotic pathway.
Phytother Res.2013 Mar;27(3):422-30.
151.Li J, Wu F, Chen K, Liang J, Ma S.
Extract of Clinopodium chinense inhibits high glucose-induced apoptosis in humanumbilical vein endothelialcells.
J Cardiovasc Pharmacol.2013 Apr;61(4):265-71.
152.Guo Z, Zhou B, Liu W, Xu Y, Wu D, Yin Z, Permatasari F, Luo D.
MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells.
J Dermatol Sci.2013 Jan;69(1):68-76.
153.Li J, Du L, Yang Y, Wang C, Liu H, Wang L, Zhang X, Li W, Zheng G, Dong Z.
MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function bytargeting SOX2.
Cancer Lett.2013 Feb 1;329(1):84-90.
154.Yin Y, Guan Y, Duan J, Wei G, Zhu Y, Quan W, Guo C, Zhou D, Wang Y, Xi M, Wen A.
Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation.
Eur J Pharmacol.2013 Jan 15;699(1-3):219-26.
155.Li Y, Jia Y, Zhou J, Huang K.
Effect of methionine sulfoxide reductase B1 silencing on high-glucose-induced apoptosisof human lens epithelialcells.
Life Sci.2013 Feb 27;92(3):193-201.
156.Guo J, Bian Y, Bai R, Li H, Fu M, Xiao C.
Globular Adiponectin Attenuates Myocardial Ischemia/Reperfusion Injury by UpregulatingEndoplasmic ReticulumCa2+-ATPase Activity and Inhibiting Endoplasmic Reticulum Stress.
J Cardiovasc Pharmacol.2013 August; 62 (2): 143-153.
157.Liu YR, Sun BC, Zhao XL, Gu Q, Liu ZY, Dong XY, Che N, Mo J.
Basal caspase-3 activity promotes migration, invasion, and vasculogenic mimicry formation of melanoma cells.
Melanoma Res.2013 August; 23 (4):243-253.
158.Zhu Y, Chi J, Liu Y, Sun Y, Fu Y, Zhang X, Ding X, Yin X, Zhao D.
Knockdown of dishevelled-1 attenuates cyclosporine A-induced apoptosis in H9c2cardiomyoblast cells.
Mol Cell Biochem.2013 Feb;374(1-2):113-23.
159.Qiu L, Chen Y, Gao M, Zheng C, Zhao Q.
Phagocytic uptake and ROS-mediated cytotoxicity in human hepatic cell line of amphiphilic polyphosphazenenanoparticles.
J Biomed Mater Res A.2013 Jan;101(1):285-97.
160.Ma J, Zhang L, Zhang J, Liu M, Wei L, Shen T, Ma C, Wang Y, Chen Y, Zhu D.
15-lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cellsgrowth through protein kinase B and heat shock protein 90 complex activation.
Int J Biochem Cell Biol.2013 Jun;45(6):1031-41.
161.Li D, Liu Z, Zhao W, Zheng X, Wang J, Wang E.
A small-molecule induces apoptosis and suppresses metastasis in pancreatic cancer cells.
Eur J Pharm Sci.2013 Mar 12;48(4-5):658-67.
162.Qiu Q, Xiong W, Yang C, Gagnon C, Hardy P.
Lymphocyte-derived microparticles induce bronchial epithelial cells' pro-inflammatorycytokine production andapoptosis.
Mol Immunol.2013 Oct;55(3-4):220-30.
163.Wang J, Wang D, Li Y, Gao Y, Wang S, Zuo H, Xu X, Wang S, Peng R.
Microarray Analysis of Altered Gene Expression and the Role of ATF3 in HK-2 Cells Treated with Hemin.
Ren Fail.2013;35(5):624-32.
164.Wang J, Jiang Z, Ji J, Wang X, Wang T, Zhang Y, Tai T, Chen M, Sun L, Li X, Zhang L.
Gene expression profiling and pathway analysis of hepatotoxicity induced by triptolidein Wistar rats.
Food Chem Toxicol.2013 Aug; 58:495-505.
165.Song S, Wang S, Ma J, Yao L, Xing H, Zhang L, Liao L, Zhu D.
Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth musclecells through ERK1/2 pathway.
Exp Cell Res.2013 August; 319(13):1973-87.
166.Yang F, Sun X, Shen J, Yu LP, Liang JY, Zheng HQ, Wu ZD.
A recombined protein (rSj16) derived from Schistosoma japonicum induces cell cycle arrest and apoptosis ofmurine myeloid leukemia cells.
Parasitol Res.2013 Mar;112(3):1261-72.
167.Wu WY, Wang WY, Ma YL, Yan H, Wang XB, Qin Y, Su M, Chen T, Wang YP.
Akt mediates sodium tanshinone IIA silate inhibition of oxygen-glucosedeprivation/reperfusion-induced myocardial cell apoptosis via suppression of the NF-κB/TNF-α pathway.
Br J Pharmacol.2013 Mar 20.
168.Yao W, Cai X, Liu C, Qin Y, Cheng H, Ji S, Xu W, Wu C, Chen T, Xu J, Long J, Fang Z,
Qu B, Hoth M, Ni Q, Zha X, Yu X.
Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells.
Curr Mol Med.2013 Mar;13(3):417-28.
169.Tian Y, Zhang X, Zhang K, Song Z, Wang R, Huang S, Lin Z.
Effect of Enterococcus faecalis Lipoteichoic Acid on Apoptosis in Human Osteoblast-like Cells.
J Endod.2013 May;39(5):632-7.
170.Cui W, Ma J, Wang X, Yang W, Zhang J, Ji Q.
Free fatty acid induces endoplasmic reticulum stress and apoptosis of β-cells byCa2+/calpain-2 pathways.
PLoS One.2013;8(3):e59921.
171.Jing C, Li X, Zhang J, Wang J.
Responses of the Antioxidant System in QGY-7701 Cells to the Cytotoxicity and ApoptosisInduced by 1-Octyl-3-methylimidazolium Chloride.
J Biochem Mol Toxicol.2013 Jun;27(6):330–6.
172.Zhu D, Yu H, He H, Ding J, Tang J, Cao D, Hao L.
Spironolactone inhibits apoptosis in rat mesangial cells under hyperglycaemic conditions via the Wnt signallingpathway.
Mol Cell Biochem.2013, Aug;380(1-2):185-93.
173.Kun D, Xiang-Lin C, Ming Z, Qi L.
Chlamydia inhibit host cell apoptosis by inducing Bag-1 via the MAPK/ERK survivalpathway.
Apoptosis.2013 Sep;18(9):1083-92.
174.Tian R, Tan JT, Wang RL, Xie H, Qian YB, Yu KL.
The role of intestinal mucosa oxidative stress in gut barrier dysfunction of severe acute pancreatitis.
Eur Rev Med Pharmacol Sci.2013 Feb;17(3):349-55.
175.Jiang ZQ, Yan XJ, Bi L, Chen JP, Zhou Q, Chen WP.
Mechanism for hepato-protective action of Liangxue Huayu Recipe (LHR): Blockade ofmitochondrial cytochrome c release and caspase activation.
J Ethnopharmacol.2013 Jul;148(3):851–60.
176.Wu B, Lin R, Dai R, Chen C, Wu H, Hong M.
Valsartan attenuates oxidative stress and NF-κB activation and reduces myocardialapoptosis after ischemia and reperfusion.
Eur J Pharmacol.2013 Apr 5;705(1-3):140-7.
177.Peng W, Chen J, Qin Y, Yang Z, Zhu YY.
Long Double-Stranded Multiplex siRNAs for Dual Genes Silencing.
Nucleic Acid Ther.2013 August; 23(4):281-288.
178.Li ZL, Hu J, Li YL, Xue F, Zhang L, Xie JQ, Liu ZH, Li H, Yi DH, Liu JC, Wang SW.
The effect of hyperoside on the functional recovery of the ischemic/reperfused isolatedrat heart: potential involvement of the extracellular signal-regulated kinase 1/2signaling pathway.
Free Radic Biol Med.2013 Apr; 57:132-40.
179.Zheng F, He K, Li X, Zhao D, Sun F, Zhang Y, Nie D, Li X, Chu W, Sun Y, Lu Y.
Transient over-expression of TGFBR3 induces apoptosis in human nasopharyngeal carcinomaCNE-2Z cells.
Biosci Rep.2013 Mar 13;33(2):e00029.
180.Dan K, Yuehua G, Yanmei Z, Aodi L, Nannan D, Ying P, Yuan Y.
The Biological Activity of H.Pylori SlyD in Vitro.
Helicobacter.2013 October;18(5): 347-355.
181.Jin M, Zhang L, Yu H, Meng J, Sun Z, Lu R.
Protective effect of whey protein hydrolysates on H2O2-induced PC12 cells oxidativestress via a mitochondria-mediated pathway.
Food Chemistry.2013 Nov;141(2):847–52.
182.Wang B, Zhang Q, Zhu B, Cui Z, Zhou J.
Protective effect of gadolinium chloride on early warm ischemia/reperfusion injury in rat bile duct during livertransplantation.
PLoS One.2013;8(1):e52743.
183.Cao ZH, Yin WD, Zheng QY, Feng SL, Xu GL, Zhang KQ.
Caspase-3 is Involved in IFN-γ- and TNF-α-Mediated MIN6 Cells Apoptosis via NF-κB/Bcl-2Pathway.
Cell Biochem Biophys.2013 December; 67(3):1239-1248 .
184.Liu Z, Dong X, Song L, Zhang H, Liu L, Zhu D, Song C, Leng X.
Carboxylation of multiwalled carbon nanotube enhanced its biocompatibility with L02 cells through decreasedactivation of mitochondrial apoptotic pathway.
J Biomed Mater Res A.2014 Mar;102(3):665–73. 
185.Xu X, Wen H, Hu Y, Yu H, Zhang Y, Chen C, Pan X.
STAT1-caspase 3 pathway in the apoptotic process associated with steroid-inducednecrosis of the femoral head.
J Mol Histol. 2014 Aug;45(4):473-85.
186.Liu H, Wang J, Li S.
E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy andcaspase activity in Drosophila fat body.
Insect Biochem Mol Biol. 2014 Feb;45:30-9.
187.Zuo H, Lin T, Wang D, Peng R, Wang S, Gao Y, Xu X, Li Y, Wang S, Zhao L, Wang L, ZhouH.
Neural cell apoptosis induced by microwave exposure through mitochondria-dependentcaspase-3 pathway.
Int J Med Sci. 2014 Mar 9;11(5):426-35.
188.Yang SD, Bai ZL, Zhang F, Ma L, Yang DL, Ding WY.
Levofloxacin increases the effect of serum deprivation on anoikis of rat nucleuspulposus cells via Bax/Bcl-2/caspase-3 pathway.
Toxicol Mech Methods. 2014 Sep 23:1-9.
189.Zheng L, Fu Y, Zhuang L, Gai R, Ma J, Lou J, Zhu H, He Q, Yang B.
Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergisticanticancer activity of celastrol and SAHA in vitro and in vivo.
Int J Cancer. 2014 Oct 1;135(7):1721-32.190.Liu Q.
Lentivirus mediated interference of Caspase-3 expression ameliorates the heart functionon rats with acute myocardial infarction.
Eur Rev Med Pharmacol Sci. 2014 Jul;18(13):1852-8.
191.Li JP, Cao NX, Jiang RT, He SJ, Huang TM, Wu B, Chen DF, Ma P, Chen L, Zhou SF, Xie XX,Luo GR.
Knockdown of GCF2/LRRFIP1 by RNAi causes cell growth inhibition and increased apoptosisin human hepatoma HepG2 cells.
Asian Pac J Cancer Prev. 2014;15(6):2753-8.
192.Nie H, Hong Y, Lu X, Zhang J, Chen H, Li Y, Ma Y, Ying W.
SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells.
Neuroreport. 2014 August; 25(11): 838–842.
193.Chen H, Xing B, Wang L, Weng X, Chen Z, Liu X.
Aged kidneys are refractory to ischemic postconditioning in a rat model.
Ren Fail. 2014 Aug 26:1-6.
194.Wang H, Zhang B, Gu M, Li S, Chi Z, Hao L.
Overexpression of the dependence receptor UNC5H4 inhibits cell migration and invasion,and triggers apoptosis in neuroblastoma cell.
Tumour Biol. 2014 Jun;35(6):5417-25.
195.Duan Y, Gu X, Zhu D, Sun W, Chen J, Feng J, Song K, Xu F, He X, He X.
Schistosoma japonicum soluble egg antigens induce apoptosis and inhibit activation ofhepatic stellate cells: a possible molecular mechanism.
Int J Parasitol. 2014 Mar;44(3-4):217-24.
196.Tian H, Guo M, Zhuang Y, Chu J, Zhang S.
Enhanced proliferation of bone marrow mesenchymal stem cells by co-culture with TM4mouse Sertoli cells: involvement of the EGF/PI3K/AKT pathway.
Mol Cell Biochem. 2014 Aug;393(1-2):155-64.
197.Li X, Chen N, Su Y, He Y, Yin M, Wei M, Wang L, Huang W, Fan C, Huang Q.
Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells.
Adv Healthc Mater. 2014 Mar;3(3):354-9.
198.Rehman K, Fu YJ, Zhang YF, Wang QQ, Wu Y, Zhou XY, Sun WH, Sun TF, Naranmandura H.
Trivalent methylated arsenic metabolites induce apoptosis in human myeloid leukemicHL-60 cells through generation of reactive oxygen species.
Metallomics. 2014 Aug;6(8):1502-12.
199.Sun C, Xu S, Guo J, Xu K, Wang C.
The inhibitory and apoptotic effects of docetaxel-loaded mesoporous magnetic colloidalnanocrystal clusters on bladder cancer T24 cells in vitro.
J Biomed Nanotechnol. 2014 Mar;10(3):455-62.
200.Ren Y, Zheng J, Yao X, Weng G, Wu L.
Essential role of the cGMP/PKG signaling pathway in regulating the proliferation andsurvival of human renal carcinoma cells.
Int J Mol Med. 2014 Nov;34(5):1430-8.
201.Xu C, Hu Y, Hou L, Ju J, Li X, Du N, Guan X, Liu Z, Zhang T, Qin W, Shen N, Bilal MU,Lu Y, Zhang Y, Shan H.
β-Blocker carvedilol protects cardiomyocytes against oxidative stress-induced apoptosisby up-regulating miR-133 expression.
J Mol Cell Cardiol. 2014 Oct;75:111-21.
202.Ding X, Zhang B, Pei Q, Pan J, Huang S, Yang Y, Zhu Z, Lv Y, Zou X.
Triptolide induces apoptotic cell death of human cholangiocarcinoma cells throughinhibition of myeloid cell leukemia-1.
BMC Cancer. 2014 Apr 17;14:271.
203.Chang G, Zhang D, Liu J, Zhang P, Ye L, Lu K, Duan Q, Zheng A, Qin S.
Exenatide protects against hypoxia/reoxygenation-induced apoptosis by improvingmitochondrial function in H9c2 cells.
Exp Biol Med (Maywood). 2014 Apr; 239(4):414-22. 
204.Qiu Q, Xiong W, Yang C, Dai X, Dan X, Yang Z, Jiao Y, Xiang Y, Liu G, Hardy P.
Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells throughactivation of p38 MAPK and production of arachidonic acid.
Apoptosis. 2014 Jul;19(7):1113-27.
205.Yang B, He K, Zheng F, Wan L, Yu X, Wang X, Zhao D, Bai Y, Chu W, Sun Y, Lu Y.
Over-expression of hypoxia-inducible factor-1 alpha in vitro protects the cardiacfibroblasts from hypoxia-induced apoptosis.
J Cardiovasc Med (Hagerstown). 2014 Jul;15(7):579-86.
206.Zuo H, Lin T, Wang D, Peng R, Wang S, Gao Y, Xu X, Zhao L, Wang S, Su Z.
RKIP Regulates Neural Cell Apoptosis Induced by Exposure to Microwave Radiation PartlyThrough the MEK/ERK/CREB Pathway.
Mol Neurobiol. 2015;51(3):1520-9.
207.Wang S, Zhang X, Yuan Y, Tan M, Zhang L, Xue X, Yan Y, Han L, Xu Z.
BRG1 expression is increased in thoracic aortic aneurysms and regulates proliferationand apoptosis of vascular smooth muscle cells through the long non-coding RNA HIF1A-AS1in vitro.
Eur J Cardiothorac Surg. 2015 Mar;47(3):439-46.
208.C. Yu, Z. Zhou, J. Wang, J. Sun, W. Liu, Y. Sun, B. Kong, H. Yang and S. Yang.
In depth analysis of apoptosis induced by silica coated manganese oxide nanoparticlesin vitro.
Journal of Hazardous Materials.2015;283:519-28.
209.B. Zhang, Z. Xu, Y. Zhang, X. Shao, J. Cheng, Z. Li.
Fipronil induces apoptosis through caspase-dependent mitochondrial pathways inDrosophila S2 cells.
Pesticide Biochemistry and Physiology. 2015 Mar;119:81–9.
210.D Zhu, H Wang, J Zhang, X Zhang, C Xin.
Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses.
Journal of Molecular and Cellular Cardiology. 2015 Oct;87:138–47.
211.Z. Liu, L. Gan, Z. Zhou, W. Jin and C. Sun.
SOCS3 promotes inflammation and apoptosis via inhibiting JAK2/STAT3 signaling pathway in3T3-L1 adipocyte.
Immunobiology. 2015;220(8):947-53.
212.W. Yin, B. Li, X. Li, F. Yu, Q. Cai, Z. Zhang, J. Wang, J. Zhang, R. Zhou, M. Chengand H. Gao.
Critical role of prohibitin in endothelial cell apoptosis caused by glycated low-densitylipoproteins and protective effects of grape seed procyanidin B2.
Journal of Cardiovascular Pharmacology 2015; 65(1):13-21.
213.WX Duan, MD He, L Mao, FH Qian, YM Li, HF Pi.
NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchialepithelial cells.
Toxicology and Applied Pharmacology.2015 Jul;286(2):80–91.
214.LC Wang, WS Zhang, Q Liu, J Li, RN Alolga.
A standardized notoginseng extract exerts cardioprotection by attenuating apoptosisunder endoplasmic reticulum stress conditions.
Journal of Functional Foods.2015 Jun;16:20–7.
215.Q Yang, S Guo, S Wang, Y Qian, H Tai.
Advanced glycation end products‐induced chondrocyte apoptosis through mitochondrialdysfunction in cultured rabbit chondrocyte.
Fundamental & Clinical Pharmacology.2015 Feb;29(1):54–61.
216.B. Qin, Y. Cao, H. Yang, B. Xiao and Z. Lu.
MicroRNA-221/222 regulate ox-LDL-induced endothelial apoptosis via Ets-1/p21 inhibition.
Molecular and cellular biochemistry. 2015 Jul; 405(1-2): 115-24.
217.K. Shen, Y. Wang, Y. Zhang, H. Zhou, Y. Song, Z. Cao, J. Kou and B. Yu.
Cocktail of four active components derived from Sheng-mai San inhibits hydrogenperoxide induced PC12 cell apoptosis linked with caspase-3/ROCK1/MLC pathway.
Rejuvenation Research. 2015 May;18(6):517-27.
218.G Huang, J Mao, Z Ji, A Ailati.
Stachyose-induced apoptosis of Caco-2 cells via the caspase-dependent mitochondrialpathway.
Food & function. 2015; 6(3):765-771.
219.Y Xing, D Yang, J Lu, DL Dong.
Insulin prevents bone morphogenetic protein-4 induced cardiomyocyte apoptosis throughactivating Akt.
Biochemical and Biophysical Research Communications. 2015 Jan;456(2):605–9.
220.P. Lin, F. Chen, J. Sun, J. Zhou, X. Wang, N. Wang, X. Li, Z. Zhang, A. Wang and Y.Jin.
Mycotoxin zearalenone induces apoptosis in mouse Leydig cells via an endoplasmicreticulum stress-dependent signalling pathway.
Reprod Toxicol.2015 Apr; 52:71-7.
221.C Lu, X Liu, C Liu, J Wang, C Li, Q Liu, Y Li.
Chlorpyrifos induces MLL translocations through caspase 3-dependent genomic instabilityand topoisomerase II inhibition in human fetal liver hematopoietic stem.
Toxicol. Sci. 2015 Oct;147(2):588-606.
222.Y. Zhao, Q. Li, W. Zhao, J. Li, Y. Sun, K. Liu, B. Liu and N. Zhang.
Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmicreticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium.
J Ethnopharmacol. 2015 Jul;169: 210-8.
223.W. J. Zhao, B. Y. Deng, X. M. Wang, Y. Miao and J. N. Wang.
XIAP associated factor 1 (XAF1) represses expression of X-linked inhibitor of apoptosisprotein (XIAP) and regulates invasion, cell cycle, apoptosis, and cisplatin sensitivityof ovarian carcinoma cells.
Asian Pac J Cancer Prev. 2015;16(6): 2453-8.
224.Z. Ke, J. Liu, P. Xu, A. Gao, L. Wang and L. Ji.
The Cardioprotective Effect of Icariin on Ischemia-Reperfusion Injury in Isolated RatHeart: Potential Involvement of the PI3K-Akt Signaling Pathway.
Cardiovasc Ther. 2015 Jun;33(3): 134-40.
225.J. Song, J. Li, F. Hou, X. Wang and B. Liu.
Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interactingprotein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells.
Metabolism. 2015 Mar;64(3):428-37.
226.L. H. Jiang, X. L. Yuan, N. Y. Yang, L. Ren, F. M. Zhao, B. X. Luo, Y. Y. Bian, J. Y. Xu, D. X. Lu, Y. Y. Zheng, C. J. Zhang, Y. M. Diao, B. M. Xia and G. Chen.
Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediatedinjury by activating IGF1 signaling pathway.
J Steroid Biochem Mol Biol. 2015 Aug;152:45-52.
227.J. Luo, N. Wu, B. Jiang, L. Wang, S. Wang, X. Li, B. Wang, C. Wang and D. Shi.
Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethylbenzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and InsulinResistance via PTP1B Inhibition.
Mar Drugs. 2015;13(7): 4452-69.
228.X. Zhao, K. Wang, F. Hu, C. Qian, H. Guan, K. Feng, Y. Zhou and Z. Chen.
MicroRNA-101 protects cardiac fibroblasts from hypoxia-induced apoptosis via inhibitionof the TGF-beta signaling pathway.
Int J Biochem Cell Biol. 2015 Aug; 65:155-64.
229.S. S. Yang, M. X. Zheng, H. C. Xu, X. Z. Cui, Y. Zhang, W. L. Zhao and R. Bai.
The effect of mitochondrial ATP-sensitive potassium channels on apoptosis of chickembryo cecal cells by Eimeria tenella.
Res Vet Sci. 2015 Apr; 99:188-95.
230.X. Ou, Y. Lu, L. Liao, D. Li, L. Liu, H. Liu and H. Xu.
Nitidine chloride induces apoptosis in human hepatocellular carcinoma cells through apathway involving p53, p21, Bax and Bcl-2.
Oncology reports. 2015 Mar;33(1):1264-74.
231.X. Zhang, H. Lu, Y. Wang, C. Liu, W. Zhu, S. Zheng and F. Wan.
Taurine induces the apoptosis of breast cancer cells by regulating apoptosis-relatedproteins of mitochondria.
Int J Mol Med. 2015 Jan;35(1):218-26.
232.F Bai, B Ni, M Liu, Z Feng, Q Xiong, G Shao.
Mycoplasma hyopneumoniae-derived lipid-associated membrane proteins induce inflammationand apoptosis in porcine peripheral blood mononuclear cells in vitro.
eterinary microbiology, 2015 Jan; 175(1):58–67.
233.L. Xue, J. Li, Y. Li, C. Chu, G. Xie, J. Qin, M. Yang, D. Zhuang, L. Cui, H. Zhang andX. Fu.
N-acetylcysteine protects Chinese Hamster ovary cells from oxidative injury andapoptosis induced by microcystin-LR.
Int J Clin Exp Med. 2015;8(4):4911-21.
234.Y. Yang, H. Meng, Q. Peng, X. Yang, R. Gan, L. Zhao, Z. Chen, J. Lu and Q. H. Meng.
Downregulation of microRNA-21 expression restrains non-small cell lung cancer cellproliferation and migration through upregulation of programmed cell death 4.
Cancer Gene Ther. 2015 Jan;22(1):23-9.
235.Y Qi, S Li, F Piao, Z Wang, R Chen, S Liu.
2, 5-Hexanedione induces apoptosis via a mitochondria-mediated pathway in PC12 cells.
Molecular & Cellular Toxicology. March 2015;11(1):79-87.
236. Z. Li, D. Meng, G. Li, J. Xu, K. Tian and Y. Li.
Celecoxib Combined with Diacerein Effectively Alleviates Osteoarthritis in Rats viaRegulating JNK and p38MAPK Signaling Pathways.
Inflammation. 2015 Aug;38(4):1563-72.
237.Z. Guo, Z. Liao, L. Huang, D. Liu, D. Yin and M. He.
Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrialpathway mediated by SIRT1.
Eur J Pharmacol. 2015 Jun;761: 245-253.
238.W. Li, M. Wu, L. Tang, Y. Pan, Z. Liu, C. Zeng, J. Wang, T. Wei and G. Liang.
Novel curcumin analogue 14p protects against myocardial ischemia reperfusion injurythrough Nrf2-activating anti-oxidative activity.
Toxicology and applied pharmacology. 2015 Jan;282(2): 175-83.
239.W. Xu, Y. Xu, Y. Wei, Y. Tan, H. Zhao, W. Zhao and J. Wu.
Self-complementary adeno-associated virus 5-mediated gene transduction of a novel CD40Lmutant confers direct antitumor effects in lung carcinoma.
Mol Med Rep. 2015 Jan;11(1): 482-8.
240.J. Li, X. Li, W. Xu, S. Wang, Z. Hu, Q. Zhang, X. Deng, J. Wang, J. Zhang and C. Guo.
Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis bytargeting AKT/mTOR/p70S6K and TGFbeta/Smad signalling pathways.
Liver Int. 2015 Apr;35(4): 1222-33.
241.S. Yao, H. Tian, C. Miao, D. W. Zhang, L. Zhao, Y. Li, N. Yang, P. Jiao, H. Sang, S.Guo, Y. Wang and S. Qin.
D4F alleviates macrophage-derived foam cell apoptosis by inhibiting CD36 expression andER stress-CHOP pathway.
J Lipid Res. 2015; 56(4): 836-47.
242.L. Peng.
Mice Brain Tissue Injury Induced by Diisononyl Phthalate Exposure and the ProtectiveApplication of Vitamin E.
J Biochem Mol Toxicol. 2015 Jul;29(7): 311-20.
243.J Liu, Y Xu, Z Zhang, J Wei.
Hydrogen peroxide promotes programmed cell death and salicylic acid accumulation duringthe induced production of sesquiterpenes in cultured cell suspensions of Aquilariasinensis.
Functional Plant Biology, 2015; 42(4) 337-346.
244.C. Meng, C. Liu, Y. Liu and F. Wu.
Oxysophoridine attenuates the injury caused by acute myocardial infarction in ratsthrough anti-oxidative, anti-inflammatory and anti-apoptotic pathways.
Mol Med Rep. 2015 Jan;11(1): 527-32.
245.J. Chang, H. Wang, X. Wang, Y. Zhao, D. Zhao, C. Wang, Y. Li, Z. Yang, S. Lu, Q. Zeng,J. Zimmerman, Q. Shi, Y. Wang and Y. Yang.
Molecular mechanisms of Polyphyllin I-induced apoptosis and reversal of the epithelial-mesenchymal transition in human osteosarcoma cells.
J Ethnopharmacol. 2015 Jul;170: 117-27.
246.D. Liang, A. T. Wang, Z. Z. Yang, Y. J. Liu and X. R. Qi.
Enhance Cancer Cell Recognition and Overcome Drug Resistance Using Hyaluronic Acid andalpha-Tocopheryl Succinate Based Multifunctional Nanoparticles.
Mol Pharm. 2015; 12(6): 2189-202.
247.Qin B, Cao Y, Yang H, Xiao B, Lu Z.
MicroRNA-221/222 regulate ox-LDL-induced endothelial apoptosis via Ets-1/p21 inhibition.
Mol Cell Biochem. 2015 Jul;405(1-2):115-24.
248.Song YF, Liu DZ, Cheng Y, Liu M, Ye WL, Zhang BL, Liu XY, Zhou SY. 
Dual subcellular compartment delivery of doxorubicin to overcome drug resistant and enhance antitumor activity.
Sci Rep. 2015 Nov 4;5:16125.
249.Huang G, Mao J, Ji Z, Ailati A.
Stachyose-induced apoptosis of Caco-2 cells via the caspase-dependent mitochondrial pathway.
Food Funct. 2015 Mar;6(3):765-71.
250.Xing Y, Yang D, Lu J, Dong DL.
Insulin prevents bone morphogenetic protein-4 induced cardiomyocyte apoptosis through activating Akt.
Biochem Biophys Res Commun. 2015 Jan 9;456(2):605-9.
251.Zhang Q, Li J, Liu C, Song C, Li P, Yin F, Xiao Y, Li J, Jiang W, Zong A, Zhang X. 
Protective effects of low molecular weight chondroitin sulfate on amyloid beta (Aβ)-induced damage in vitro and in vivo.
Neuroscience. 2015 Oct 1;305:169-82.
252.Xu Y, Zhu W, Wang Z, Yuan W, Sun Y, Liu H, Du Z.
Combinatorial microRNAs suppress hypoxia-induced cardiomyocytes apoptosis.
Cell Physiol Biochem. 2015;37(3):921-32.
253.Song J, Li J, Hou F, Wang X, Liu B.
Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells.
Metabolism. 2015 Mar;64(3):428-37.
254.Zhao Y, Li Q, Zhao W, Li J, Sun Y, Liu K, Liu B, Zhang N.
Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium.
J Ethnopharmacol. 2015 Jul 1;169:210-8.
255.Yu C, Zhou Z, Wang J, Sun J, Liu W, Sun Y, Kong B, Yang H, Yang S.
In depth analysis of apoptosis induced by silica coated manganese oxide nanoparticles in vitro.
J Hazard Mater. 2015;283:519-28.
256.Liu Z, Gan L, Zhou Z, Jin W, Sun C.
SOCS3 promotes inflammation and apoptosis via inhibiting JAK2/STAT3 signaling pathway in 3T3-L1 adipocyte.
Immunobiology. 2015 Aug;220(8):947-53.
257.Zhu D, Wang H, Zhang J, Zhang X, Xin C, Zhang F, Lee Y, Zhang L, Lian K, Yan W, Ma X, Liu Y, Tao L.
Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses.
J Mol Cell Cardiol. 2015 Oct;87:138-47.
258.Sha WG, Shen L, Zhou L, Xu DY, Lu GY.
Down-regulation of miR-186 contributes to podocytes apoptosis in membranous nephropathy.
Biomed Pharmacother. 2015 Oct;75:179-84.
259.Sun W, Li L, Yang Q, Shan W, Zhang Z, Huang Y. 
G3-C12 Peptide Reverses Galectin-3 from Foe to Friend for Active Targeting Cancer Treatment.
Mol Pharm. 2015 Nov 2;12(11):4124-36.
260.Duan WX, He MD, Mao L, Qian FH, Li YM, Pi HF, Liu C, Chen CH, Lu YH, Cao ZW, Zhang L, Yu ZP, Zhou Z.
NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells.
Toxicol Appl Pharmacol. 2015 Jul 15;286(2):80-91.
261.Zhang D, Zhou XH, Zhang J, Zhou YX, Ying J, Wu GQ, Qian JH.
Propofol promotes cell apoptosis via inhibiting HOTAIR mediated mTOR pathway in cervical cancer.
Biochem Biophys Res Commun. 2015 Dec 25;468(4):561-7.
262.Yin W, Li B, Li X, Yu F, Cai Q, Zhang Z, Wang J, Zhang J, Zhou R, Cheng M, Gao H.
Critical role of prohibitin in endothelial cell apoptosis caused by glycated low-density lipoproteins and protective effects of grape seed procyanidin B2.
J Cardiovasc Pharmacol. 2015 Jan;65(1):13-21.
263.Yang Q, Guo S, Wang S, Qian Y, Tai H, Chen Z.
Advanced glycation end products-induced chondrocyte apoptosis through mitochondrial dysfunction in cultured rabbit chondrocyte.
Fundam Clin Pharmacol. 2015 Feb;29(1):54-61.
264.Jiang LH, Yuan XL, Yang NY, Ren L, Zhao FM, Luo BX, Bian YY, Xu JY, Lu DX, Zheng YY, Zhang CJ, Diao YM, Xia BM, Chen G.
Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway.
J Steroid Biochem Mol Biol. 2015 Aug;152:45-52.
265.Yang SS, Zheng MX, Xu HC, Cui XZ, Zhang Y, Zhao WL, Bai R.
The effect of mitochondrial ATP-sensitive potassium channels on apoptosis of chick embryo cecal cells by Eimeria tenella.
Res Vet Sci. 2015 Apr;99:188-95.
266.Yu J, Zhang W, Zhang R, Jiang G, Tang H, Ruan X, Ren P, Lu B.
Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression.
Toxicol Lett. 2015 Nov 4;238(3):11-9.
267.Ou X, Lu Y, Liao L, Li D, Liu L, Liu H, Xu H.
Nitidine chloride induces apoptosis in human hepatocellular carcinoma cells through a pathway involving p53, p21, Bax and Bcl-2.
Oncol Rep. 2015 Mar;33(3):1264-74.
268.Zhang X, Lu H, Wang Y, Liu C, Zhu W, Zheng S, Wan F.
Taurine induces the apoptosis of breast cancer cells by regulating apoptosis-related proteins of mitochondria.
Int J Mol Med. 2015 Jan;35(1):218-26.
269.Bai F, Ni B, Liu M, Feng Z, Xiong Q, Shao G.
Mycoplasma hyopneumoniae-derived lipid-associated membrane proteins induce inflammation and apoptosis in porcine peripheral blood mononuclear cells in vitro.
Vet Microbiol. 2015 Jan 30;175(1):58-67.
270.Zhao X, Wang K, Hu F, Qian C, Guan H, Feng K, Zhou Y, Chen Z.
MicroRNA-101 protects cardiac fibroblasts from hypoxia-induced apoptosis via inhibition of the TGF-β signaling pathway.
Int J Biochem Cell Biol. 2015 Aug;65:155-64.
271.Yang Y, Meng H, Peng Q, Yang X, Gan R, Zhao L, Chen Z, Lu J, Meng QH.
Downregulation of microRNA-21 expression restrains non-small cell lung cancer cell proliferation and migration through upregulation of programmed cell death 4.
Cancer Gene Ther. 2015 Jan;22(1):23-9.
272.Xu W, Xu Y, Wei Y, Tan Y, Zhao H, Zhao W, Wu J.
Self-complementary adeno-associated virus 5-mediated gene transduction of a novel CD40L mutant confers direct antitumor effects in lung carcinoma.
Mol Med Rep. 2015 Jan;11(1):482-8.
273.Guo Z, Liao Z, Huang L, Liu D, Yin D, He M.
Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1.
Eur J Pharmacol. 2015 Aug 15;761:245-53.
274.Liang D, Wang AT, Yang ZZ, Liu YJ, Qi XR. 
Enhance Cancer Cell Recognition and Overcome Drug Resistance Using Hyaluronic Acid and α-Tocopheryl Succinate Based Multifunctional Nanoparticles.
Mol Pharm. 2015 Jun 1;12(6):2189-202.
275.Fan Q, Zhan X, Xiao Z, Liu C.
Phenethyl isothiocyanate enhances adriamycin induced apoptosis in osteosarcoma cells.
Mol Med Rep. 2015 Oct;12(4):5945-50.
276.Meng C, Liu C, Liu Y, Wu F.
Oxysophoridine attenuates the injury caused by acute myocardial infarction in rats through anti-oxidative, anti-inflammatory and anti-apoptotic pathways.
Mol Med Rep. 2015 Jan;11(1):527-32.
277.Zhang L, Li Z, Gai F, Wang Y.
MicroRNA-137 suppresses tumor growth in epithelial ovarian cancer in vitro and in vivo.
Mol Med Rep. 2015 Aug;12(2):3107-14.
278.Wang L, Liu C, Li C, Xue J, Zhao S, Zhan P, Lin Y, Zhang P, Jiang A, Chen W.
Effects of microRNA-221/222 on cell proliferation and apoptosis in prostate cancer cells.
Gene. 2015 Nov 10;572(2):252-8.
279.Sun L, Song J, Peng C, Xu C, Yuan X, Shi J.
Mechanistic study of programmed cell death of root border cells of cucumber (Cucumber sativus L.) induced by copper.
Plant Physiol Biochem. 2015 Dec;97:412-9.
280.Pu Z, Zhu M, Kong F. 
Telmisartan prevents proliferation and promotes apoptosis of human ovarian cancer cells through upregulating PPARγ and downregulating MMP 9 expression.
Mol Med Rep. 2016 Jan;13(1):555-9. 
281.Zhang Q, Fan K, Wang P, Yu J, Liu R, Qi H, Sun H, Cao Y. 
Carvacrol induces the apoptosis of pulmonary artery smooth muscle cells under hypoxia.
Eur J Pharmacol. 2016 Jan;700(5):134-46.
282.Chen Z, Wang R, Wu J, Xia F, Sun Q, Xu J, Liu L. 
Low-dose carbon monoxide inhalation protects neuronal cells from apoptosis after optic nerve crush.
Biochem Biophys Res Commun. 2016 Jan;469(4):809-15.
283.Wu Y, Shu J, He C, Li M, Wang Y, Ou W, He Y. 

ROCK inhibitor Y27632 promotes proliferation and diminishes apoptosis of marmoset induced pluripotent stem cells by suppressing expression and activity of caspase 3.
Theriogenology. 2016 Jan 15;85(2):302-14. 
284.Li Y, Chen M, Xu Y, Yu X, Xiong T, Du M, Sun J, Liu L, Tang Y, Yao P.
Iron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage andApoptosis: Protective Effects of Quercetin.
Oxid Med Cell Longev. 2016;2016:4147610. 
285.Wu H, Lin J, Liu P, Huang Z, Zhao P, Jin H, Ma J, Wen L, Gu N.
Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs.
Biomaterials. 2016 Sep;101:1-9. 
286.Yang SD, Ma L, Yang DL, Ding WY.
Combined effect of 17β-estradiol and resveratrol against apoptosis induced by interleukin-1β in ratnucleus pulposus cells via PI3K/Akt/caspase-3 pathway.
PeerJ. 2016 Jan 26;4:e1640. 
287.Zheng M, Liu C, Fan Y, Shi D, Zhang Y. 
Protective Effects of Paeoniflorin Against MPP(+)-induced Neurotoxicity in PC12 Cells.
Neurochem Res. 2016 Jun;41(6):1323-34. 
288.Jiao S, Zhu H, He P, Teng J.
Betulinic acid protects against cerebral ischemia/reperfusion injury by activating the PI3K/Akt signalingpathway.
Biomed Pharmacother. 2016 Dec;84:1533-1537.
289.Liu Q, Tao B, Liu G, Chen G, Zhu Q, Yu Y, Yu Y, Xiong H.
Thromboxane A2 Receptor Inhibition Suppresses Multiple Myeloma Cell Proliferation by Inducing p38/c-Jun N-terminal Kinase (JNK) Mitogen-activated Protein Kinase (MAPK)-mediated G2/M Progression Delay and Cell Apoptosis. 
J Biol Chem. 2016 Feb 26;291(9):4779-92. 
290.Chu W, Wei W, Yu S, Han H, Shi X, Sun W, Gao Y, Zhang L, Chen J.
C2C12 myotubes inhibit the proliferation and differentiation of 3T3-L1 preadipocytes by reducing theexpression of glucocorticoid receptor gene.
Biochem Biophys Res Commun. 2016 Mar 25;472(1):68-74. 
291.Li W, Jiang B, Cao X, Xie Y, Huang T. 
Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis throughoxidative stress-mediated Caspase pathways.
Chem Biol Interact. 2017 Jan 5;261:27-34.