Lyso-Tracker Red (溶酶体红色荧光探针)(C1046)

试剂> 细胞相关> 细胞分析> 细胞组织染色

Lyso-Tracker Red (溶酶体红色荧光探针)

赠：

产品编号: C1046

产品包装:50μl

选择包装

50μl

数

量

支

说明书下载

价格:¥368.00元

加入购物车

				产品简介
			
				使用说明
			
				产品图片
			
				相关产品
			
				相关论文
			
				产品问答

产品编号	产品名称	产品包装	产品价格
C1046	Lyso-Tracker Red (溶酶体红色荧光探针)	50μl	368.00元

Lyso-Tracker Red是一种溶酶体(lysosome)红色荧光探针，能通透细胞膜,可以用于活细胞溶酶体特异性荧光染色。
Lyso-Tracker Red为采用Molecular Probes公司的DND-99进行了荧光标记的带有弱碱性的荧光探针，其中仅弱碱可部分提供质子，以维持pH在中性,可以选择性地滞留在偏酸性的溶酶体中，从而实现对于溶酶体的特异性荧光标记。中性红(Neutral Red)和吖啶橙(Acridine Orange)也都可以对溶酶体进行荧光染色，但中性红和吖啶橙的染色缺乏特异性。Lyso-Tracker Red分子的化学结构式参考图1。
图1.Lyso-Tracker Red的化学结构式。 Lyso-Tracker Red的分子式为C₂₀H₂₄BF₂N₅O，分子量为399.25，最大激发波长为577nm，最大发射波长为590nm。Lyso-Tracker Red的激发光谱和发射光谱参考图2。
图2.Lyso-Tracker Red的激发光谱和发射光谱。 Lyso-Tracker Red是嗜酸性荧光探针，用于活细胞内酸性细胞器的标记和示踪。这些探针具有几个重要特征，包括高度选择靶向酸性细胞器和在纳摩尔浓度有效标记活细胞。Lyso-Tracker Red必须在极低浓度(通常约50nM)下才能获得优异的选择性。这些探针的滞留(retention)机制虽然没有被研究清楚，但很可能与酸性细胞器的质子化和滞留性有关，Lyso-Tracker Red探针的内吞作用动力学研究显示染料进入活细胞的摄入时间仅几秒即可。然而，这些溶酶体探针会导致溶酶体被碱化，长期孵育会诱使溶酶体pH值的增加。因此，建议成像前用探针孵育细胞的时间不能太久。Lyso-Tracker Red探针具体使用浓度和孵育时间需要根据自身实验条件和具体细胞种类来进行摸索以达到满意的染色效果。Lyso-Tracker Red在活细胞中染色效果参考图3。
图3.Lyso-Tracker Red在HeLa细胞中的染色效果。Hoechst 33342染色的HeLa细胞其细胞核呈现蓝色荧光；Lyso-Tracker Red染色HeLa细胞的溶酶体，呈现红色荧光。
按照1:20000的比例稀释，可以配制1000ml Lyso-Tracker Red工作液。
包装清单：

产品编号	产品名称	包装
C1046	Lyso-Tracker Red (1mM)	50µl
－	说明书	1份

保存条件：
-20℃避光保存，半年有效。
注意事项：
Lyso-Tracker Red (1mM)在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内，可以20-25℃水浴温育片刻至全部融解后使用。对于微量的液体，每次使用前先离心数秒钟，使液体充分沉降到管底。
荧光染料均存在淬灭问题，请尽量注意避光，以减缓荧光淬灭。
需自备盖玻片和载玻片(可以向碧云天订购)。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：
1.Lyso-Tracker Red工作液的配制：
a.取少量Lyso-Tracker Red按照1:13333-1:20000的比例加入到细胞培养液或适当的溶液(例如含钙镁离子的HBSS)中，使最终浓度为50-75nM。例如取1µl Lyso-Tracker Red加入到20ml或13.33ml细胞培养液或适当的溶液(例如含钙镁离子的HBSS)中。混匀后即为Lyso-Tracker Red工作液。HBSS with Ca²⁺ & Mg²⁺ (C0219)可以向碧云天订购。
b.Lyso-Tracker Red工作液使用前需37℃预温育。
注：工作液中Lyso-Tracker Red的浓度可以根据实际情况进行适当调整。为降低背景，在染色效果可以接受的范围内，建议尽量使用较低浓度的Lyso-Tracker Red。
2.溶酶体的荧光标记：
a.去除细胞培养液，加入步骤1配制好的并37℃预温育的Lyso-Tracker Red染色工作液，与细胞37℃共孵育5-60分钟。
b.去除Lyso-Tracker Red染色工作液，加入新鲜的细胞培养液。
c.随后通常用荧光显微镜或激光共聚焦显微镜进行观察。此时可观察到溶酶体呈明亮的强荧光染色。如果染色效果欠佳，可以提高Lyso-Tracker Red染色工作液中Lyso-Tracker Red的浓度或在推荐的时间范围内适当延长染色时间。

相关产品：

产品编号	产品名称	包装
C1002	DAPI	5mg/ml×0.2ml
C1005/C1006	DAPI染色液	10ml/50ml
C1011	Hoechst 33258	10mg
C1017/C1018	Hoechst 33258染色液	10ml/50ml
C1022	Hoechst 33342	10mg
C1025/C1026	Hoechst 33342染色液	10ml/50ml
C1027/C1028	Hoechst 33342活细胞染色液(100X)	0.1ml/0.5ml
C1031	CFDA SE (细胞增殖示踪荧光探针)	5mg
C1033	Actin-Tracker Green (微丝绿色荧光探针)	0.2ml
C1036	DiI (细胞膜红色荧光探针)	10mg
C1038	DiO (细胞膜绿色荧光探针)	10mg
C1041	ER-Tracker Red (内质网红色荧光探针)	20μl
C1043	Golgi-Tracker Red (高尔基体红色荧光探针)	1mg
C1046	Lyso-Tracker Red (溶酶体红色荧光探针)	50μl
C1048	Mito-Tracker Green (线粒体绿色荧光探针)	50μg
C1050	Tubulin-Tracker Red (微管红色荧光探针)	40μl
C2005	JC-1	1mg
C2006	线粒体膜电位检测试剂盒(JC-1)	>100次
C2007	Rhodamine 123	5mg
S0019	DAF-FM DA (NO荧光探针)	>100次
S0063	Dihydroethidium (超氧化物阴离子荧光探针)	5mg
S1006	BCECF AM (pH荧光探针, 5mM)	50微升
S1052	Fura-2 AM (钙离子荧光探针, 2mM)	50微升
S1056	Fluo-3 AM (钙离子荧光探针, 5mM)	20微升
S1060	Fluo-4 AM (钙离子荧光探针, 2mM)	25微升
S1082	MQAE (氯离子荧光探针)	20mg

相关产品请点击如下按钮：

细胞组织染色

其他荧光探针

使用本产品的文献：

1. Liu G, Ma S, Li S, Cheng R, Meng F, Liu H, Zhong Z.

The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes.

Biomaterials . 2010;31(29):7575-85. (IF 10.273)

2. Huang X, Zhuang J, Teng X, Li L, Chen D, Yan X, Tang F.

The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen species.

Biomaterials . 2010;31(24):6142-53. (IF 10.273)

3. Jialin G, Xuefan G, Huiwen Z.

SID1 transmembrane family, member 2 (Sidt2): a novel lysosomal membrane protein.

BIOCHEM BIOPH RES CO . 2010 Nov 26;402(4):588-94. (IF 2.705)

4. Wu Z, Tang M, Tian T, Wu J, Deng Y, Dong X, Tan Z, Weng X, Liu Z, Wang C, Zhou X.

A specific probe for two-photon fluorescence lysosomal imaging.

Talanta . 2011 Dec 15;87:216-21. (IF 4.916)

5. Gan Q, Dai D, Yuan Y, Qian J, Sha S, Shi J, Liu C.

Effect of size on the cellular endocytosis and controlled release of mesoporous silicananoparticles for intracellular delivery.

Biomed Microdevices . 2012 Apr;14(2):259-70. (IF 2.327)

6. Chen Y, Chen H, Zhang S, Chen F, Sun S, He Q, Ma M, Wang X, Wu H, Zhang L, Zhang L, Shi J.

Structure-property relationships in manganese oxide--mesoporous silica nanoparticles used for T1-weighted MRI and simultaneous anti-cancer drug delivery.

Biomaterials . 2012 Mar;33(7):2388-98. (IF 10.273)

7. Liu M, Li ZH, Xu FJ, Lai LH, Wang QQ, Tang GP, Yang WT.

An oligopeptide ligand-mediated therapeutic gene nanocomplex for liver cancer-targeted therapy.

Biomaterials . 2012 Mar;33(7):2240-50. (IF 10.273)

8. Wang J, Dong S.

ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPKin human umbilical vein endothelial cells.

Inflammation . 2012 Jun;35(3):859-70. (IF 2.939)

9. Hu Q, Wang J, Shen J, Liu M, Jin X, Tang G, Chu PK.

Intracellular pathways and nuclear localization signal peptide-mediated gene transfection bycationic polymeric nanovectors.

Biomaterials . 2012 Feb;33(4):1135-45. (IF 10.273)

10. Sun X, Chen J, Chen H, Liang W.

Polyethylenimine modified liposomes as potential carriers for antitumor drug delivery in vitro.

Pharmazie . 2012 May;67(5):426-31. (IF 0.82)

11. Qi Gan , Xunyu Lu , Wenjie Dong , Yuan Yuan , Jiangchao Qian , Yongsheng Li , Jianlin Shi and Changsheng Liu.

Endosomal pH-activatable magnetic nanoparticle-capped mesoporous silica for intracellular controlled release

J MATER CHEM .2012 Jun;31:15960-8. (IF 6.626)

12. Hao X, Wu J, Shan Y, Cai M, Shang X, Jiang J, Wang H.

Caveolae-mediated endocytosis of biocompatible gold nanoparticles in living Hela cells.

J PHYS-CONDENS MAT . 2012 Apr 25;24(16):164207. (IF 2.711)

13. Gao J, Xia L, Lu M, Zhang B, Chen Y, Xu R, Wang L.

TM7SF1 (GPR137B): a novel lysosome integral membrane protein.

Mol Biol Rep . 2012 Sep;39(9):8883-9. (IF 2.107)

14. Zhang E, Luo S, Tan X, Shi C.

Mechanistic study of IR-780 dye as a potential tumor targeting and drug delivery agent.

Biomaterials . 2014 Jan;35(2):771-8. (IF 10.273)

15. Du F, Min Y, Zeng F, Yu C, Wu S.

A targeted and FRET-based ratiometric fluorescent nanoprobe for imaging mitochondrial hydrogen peroxide in living cells.

Small . 2014 Mar 12;10(5):964-72. (IF 10.856)

16. He H, Xiao H, Kuang H, Xie Z, Chen X, Jing X, Huang Y.

Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery.

COLLOID SURFACE B . 2014 May 1;117:75-81. (IF 3.973)

17. Han J, Wang Q, Zhang Z, Gong T, Sun X.

Cationic bovine serum albumin based self-assembled nanoparticles as siRNA delivery vector for treating lung metastatic cancer.

Small . 2014 Feb 12;10(3):524-35. (IF 10.856)

18. Sui L, Zhang RH, Zhang P, Yun KL, Zhang HC, Liu L, Hu MX.

Lead toxicity induces autophagy to protect against cell death through mTORC1 pathway in cardiofibroblasts.

BIOSCIENCE REP . 2015 Mar 31;35(2).pii:e00186. (IF 2.535)

19. Ji GR, Yu NC, Xue X, Li ZG.

PERK-mediated Autophagy in Osteosarcoma Cells Resists ER Stress-induced Cell Apoptosis.

Int J Biol Sci . 2015 May 23;11(7):803-12. (IF 4.067)

20. Jin Y, Chen S, Duan J, Jia G, Zhang J.

Europium-doped Gd2O3 nanotubes cause the necrosis of primary mouse bone marrow stromal cells through lysosome and mitochondrion damage.

J Inorg Biochem . 2015 May;146:28-36. (IF 3.224)

21. Wang M, Wang L, Guo Y, Sun R, Yue F, Yi Q, Song L.

The broad pattern recognition spectrum of the Toll-like receptor in mollusk Zhikong scallop Chlamys farreri.

Dev Comp Immunol . 2015 Oct;52(2):192-201. (IF 3.119)

22. Wu F, Xu HD, Guan JJ, Hou YS, Gu JH, Zhen XC, Qin ZH.

Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease.

Neuroscience . 2015 Jan 22;284:900-11. (IF 3.244)

23. Jiang S, Gong X, Zhao X, Zu Y.

Preparation, characterization, and antitumor activities of folate-decorated docetaxel-loaded human serum albumin nanoparticles.

Drug Deliv . 2015 Feb;22(2):206-13. (IF 3.829)

24. Gao W, Liang JX, Liu S, Liu C, Liu XF, Wang XQ, Yan Q.

Oxidative damage of DNA induced by X-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction.

Int J Clin Exp Med . 2015 Mar 15;8(3):3401-10. (IF 0.181)

25. Yao X, Jiang J, Wang X, Huang C, Li D, Xie K, Xu Q, Li H, Li Z, Lou L, Fang J.

A novel humanized anti-HER2 antibody conjugated with MMAE exerts potent anti-tumor activity.

BREAST CANCER RES TR . 2015 Aug;153(1):123-33. (IF 3.471)

26. Fan Z, Chen C, Pang X, Yu Z, Qi Y, Chen X, Liang H, Fang X, Sha X.

Adding vitamin E-TPGS to the formulation of Genexol-PM: specially mixed micelles improve drug-loading ability and cytotoxicity against multidrug-resistant tumors significantly.

PLoS One . 2015 Apr 1;10(4):e0120129. (IF 2.776)

27. Lai L, Jin JC, Xu ZQ, Mei P, Jiang FL, Liu Y.

Necrotic cell death induced by the protein-mediated intercellular uptake of CdTe quantum dots.

Chemosphere . 2015 Sep;135:240-9. (IF 5.108)

28. He W, Yang K, Fan L, Lv Y, Jin Z, Zhu S, Qin C, Wang Y, Yin L.

Denatured globular protein and bile salt-coated nanoparticles for poorly water-soluble drugs: Penetration across the intestinal epithelial barrier into the circulation system and enhanced oral bioavailability.

INT J PHARMACOL . 2015 Nov 10;495(1):9-18. (IF 0.754)

29. Zhou J, Xi C, Wang W, Yang Y, Qiu Y, Huang Z.

Autophagy plays an important role in triptolide-induced apoptosis in cardiomyocytes.

Toxicol Lett . 2015 Aug 5;236(3):168-83. (IF 3.499)

30. Chen C, Hu H, Qiao M, Zhao X, Wang Y, Chen K, Guo X, Chen D.

Tumor-targeting and pH-sensitive lipoprotein-mimic nanocarrier for targeted intracellular delivery of paclitaxel.

INT J PHARMACOL . 2015 Mar 1;480(1-2):116-27. (IF 0.754)

31. Li LM, Ruan GX, HuangFu MY, Chen ZL, Liu HN, Li LX, Hu YL, Han M, Davidson G, Levkin PA, Gao JQ.

ScreenFect A: an efficient and low toxic liposome for gene delivery to mesenchymal stem cells.

INT J PHARMACOL . 2015 Jul 5;488(1-2):1-11. (IF 0.754)

32. Jiang S, Gong X, Zhao X, Zu Y.

Preparation, characterization, and antitumor activities of folate-decorated docetaxel-loaded human serum albumin nanoparticles.

Drug Deliv . 2015 Feb;22(2):206-13. (IF 3.829)

33. Zhao J, Yang L, Huang P, Wang Z, Tan Y, Liu H, Pan J, He CY, Chen ZY.

Synthesis and characterization of low molecular weight polyethyleneimine-terminated Poly(β-amino ester) for highly efficient gene delivery of minicircle DNA.

J COLLOID INTERF SCI . 2016 Feb 1;463:93-8. (IF 6.361)

34. Yao H, Qiu H, Shao Z, Wang G, Wang J, Yao Y, Xin Y, Zhou M, Wang AZ, Zhang L.

Nanoparticle formulation of small DNA molecules, Dbait, improves the sensitivity of hormone-independent prostate cancer to radiotherapy.

Nanomedicine . 2016 Nov;12(8):2261-2271. (IF 4.717)

35. Huang BH, Geng ZR, Ma XY, Zhang C, Zhang ZY, Wang ZL.

Lysosomal ATP imaging in living cells by a water-soluble cationic polythiophene derivative.

Biosens Bioelectron . 2016 Sep 15;83:213-20. (IF 9.518)

36. Zhao J, Yang L, Huang P, Wang Z, Tan Y, Liu H, Pan J, He CY, Chen ZY.

Synthesis and characterization of low molecular weight polyethyleneimine-terminated Poly(β-aminoester) for highly efficient gene delivery of minicircle DNA.

J COLLOID INTERF SCI . 2016 Feb 1;463:93-8. (IF 6.361)

37. Zhang J, Zhang X, Liu G, Chang D, Liang X, Zhu X, Tao W, Mei L.

Intracellular Trafficking Network of Protein Nanocapsules: Endocytosis, Exocytosis and Autophagy.

Theranostics . 2016 Sep 12;6(12):2099-2113. (IF 8.063)

38. Wang YY, Zhang DD, Kong YY, Shao LL, Zhang FY, Gao Y, Mu X, Wang J, Li HF, Yu SQ, Xu Q.

CS/PAA@TPGS/PLGA nanoparticles with intracellular pH-sensitive sequential release for delivering drugto the nucleus of MDR cells.

COLLOID SURFACE B . 2016 Sep 1;145:716-27. (IF 3.973)

39. Jin H, Pi J, Yang F, Wu C, Cheng X, Bai H, Huang D, Jiang J, Cai J, Chen ZW.

Ursolic acid-loaded chitosan nanoparticles induce potent anti-angiogenesis in tumor.

APPL MICROBIOL BIOT . 2016 Aug;100(15):6643-52. (IF 3.67)

40. Jin H, Pi J, Yang F, Jiang J, Wang X, Bai H, Shao M, Huang L, Zhu H, Yang P, Li L, Li T, Cai J, Chen ZW.

Folate-Chitosan Nanoparticles Loaded with Ursolic Acid Confer Anti-Breast Cancer Activities in vitro and in vivo.

SCI REP-UK . 2016 Jul 29;6:30782. (IF 4.011)

41. Chen K, Chen Q, Wang K, Zhu J, Li W, Li W, Qiu L, Guan G, Qiao M, Zhao X, Hu H, Chen D.

Synthesis and characterization of a PAMAM-OH derivative containing an acid-labile β-thiopropionatebond for gene delivery.

INT J PHARMACOL . 2016 Jul 25;509(1-2):314-27. (IF 0.754)

42. Mao QX, E S, Xia JM, Song RS, Shu Y, Chen XW, Wang JH.

Hydrophobic Carbon Nanodots with Rapid Cell Penetrability and Tunable Photoluminescence Behaviorfor in Vitro and in Vivo Imaging.

Langmuir . 2016 Nov 22;32(46):12221-12229. (IF 3.683)

43. Ma K, Fu D, Yu D, Cui C, Wang L, Guo Z, Mao C.

Targeted delivery of in situ PCR-amplified Sleeping Beauty transposon genes to cancer cells with lipid-based nanoparticle-like protocells.

Biomaterials . 2017 Jan 2;121:55-63. (IF 10.273)

44. Zhang H, Yan T, Xu S, Feng S, Huang D, Fujita M, Gao XD.

Graphene oxide-chitosan nanocomposites for intracellular delivery of immunostimulatory CpGoligodeoxynucleotides.

MAT SCI ENG C-MATER . 2017 Apr 1;73:144-151. (IF 4.959)

45. Fang X, Tong Y, Tian H, Ning H, Gao X, Yao W.

Rapid de novo generation of antigen specific human B cells with expression of Blimp-1 and AID by in vitro immunization.

Exp Cell Res . 2017 Mar 1;352(1):53-62. (IF 3.329)

46. Jia Z, Wang L, Jiang S, Sun M, Wang M, Yi Q, Song L.

Functional characterization of hemocytes from Chinese mitten crab Eriocheir sinensis by flowcytometry.

FISH SHELLFISH IMMUN . 2017 Oct;69:15-25. (IF 3.298)

47. Luo C, Chen S, Xu N, Sai WB, Zhao W, Li YC, Hu XJ, Tian H, Gao XD, Yao WB.

Establishment ofa fluorescence-based method to evaluate endocytosis of desialylatedglycoproteins in vitro.

Biomed Pharmacother . 2017 Apr;88:87-94. (IF 3.743)

48. Zhang H, Wang Y, Wu Y, Jiang X, Tao Y, Yao Y, Peng Y, Chen X, Fu Y, Yu L, Wang R, Lai Q, Lai W, Li W, Kang Y, Yi S, Lu Y, Gou L, Wu M, Yang J.

Therapeutic potential ofan anti-HER2 single chain antibody-DM1 conjugates forthe treatment of HER2-positive cancer.

Signal Transduct Target Ther . 2017 May 19;2:17015.

49. Hao Y, Zheng C, Wang L, Zhang J, Niu X, Song Q, Feng Q, Zhao H, Li L, Zhang H, Zhang Z, Zhang Y.

Tumor acidity-activatable manganese phosphate nanoplatform for amplification of photodynamiccancer therapy and magnetic resonance imaging.

Acta Biomater . 2017 Oct 15;62:293-305. (IF 6.638)

50. Zhang Q,Wang D,Zhang H,Wang M,Li P,Fang X,Cai X

Detection of autophagy processes during the development of nonarticulated laticifers in Euphorbia kansui Liou.

Planta . 2018 Apr;247(4):845-861. (IF 3.06)

51. Li L,Sun B,Gao Y,Niu H,Yuan H,Lou H

STAT3 contributes to lysosomal-mediated cell death in a novel derivative of riccardin D-treated breast cancer cells in association with TFEB.

Biochem Pharmacol . 2018 Apr;150:267-279. (IF 4.825)

52. Zhang Q,Wang D,Zhang H,Wang M,Li P,Fang X,Cai X

Detection of autophagy processes during the development of nonarticulated laticifers in Euphorbia kansui Liou.

Planta . 2018 Apr;247(4):845-861. (IF 3.06)

53. Chen F,Song Q,Yu Q

Axl inhibitor R428 induces apoptosis of cancer cells by blocking lysosomal acidification and recycling independent of Axl inhibition.

Am J Cancer Res. 2018 Aug 1;8(8):1466-1482. eCollection 2018. (IF 4.737)

54. Chen F,Song Q,Yu Q

Axl inhibitor R428 induces apoptosis of cancer cells by blocking lysosomal acidification and recycling independent of Axl inhibition.

Am J Cancer Res. 2018 Aug 1;8(8):1466-1482. eCollection 2018. (IF 4.737)

55. Liu B,Cao W,Li J,Liu J

Lysosomal exocytosis of ATP is coupled to P2Y2 receptor in marginal cells in the stria vascular in neonatal rats.

Cell Calcium . 2018 Dec;76:62-71. (IF 3.932)

56. Liu B,Cao W,Li J,Liu J

Lysosomal exocytosis of ATP is coupled to P2Y2 receptor in marginal cells in the stria vascular in neonatal rats.

Cell Calcium . 2018 Dec;76:62-71. (IF 3.932)

57. Lv Z,Qiu L,Liu Z,Wang W,Chen H,Jia Y,Jia Z,Jiang S,Wang L,Song L

Molecular characterization of a cathepsin L1 highly expressed in phagocytes of pacific oyster Crassostrea gigas.

Dev Comp Immunol . 2018 Dec;89:152-162. (IF 3.119)

58. Sun D,Zhao L,Lin J,Zhao Y,Zheng Y

Cationic liposome co-encapsulation of SMAC mimetic and zVAD using a novel lipid bilayer fusion loaded with MLKL-pDNA for tumour inhibition in vivo.

J Drug Target . 2018 Jan;26(1):45-54. (IF 3.277)

59. Zhang L,Qin Y,Zhang Z,Fan F,Huang C,Lu L,Wang H,Jin X,Zhao H,Kong D,Wang C,Sun H,Leng X,Zhu D

Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination therapy.

Acta Biomater . 2018 Jul 15;75:371-385. (IF 6.638)

60. Liu H,Wang J,Li W,Hu J,Wang M,Kang Y

Cellular Uptake Behaviors of Rigidity-Tunable Dendrimers.

Pharmaceutics . 2018 Jul 19;10(3). pii: E99. (IF 4.773)

61. E S,Mao QX,Yuan XL,Kong XL,Chen XW,Wang JH

Targeted imaging of the lysosome and endoplasmic reticulum and their pH monitoring with surface regulated carbon dots.

Nanoscale . 2018 Jul 9;10(26):12788-12796. (IF 6.97)

62. Xu C,Wang W,Zhong J,Lei F,Xu N,Zhang Y,Xie W

Canagliflozin exerts anti-inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells.

Biochem Pharmacol . 2018 Jun;152:45-59. (IF 4.825)

63. Liu X,Wu L,Wang L,Jiang W

A dual-targeting DNA tetrahedron nanocarrier for breast cancer cell imaging and drug delivery.

Talanta . 2018 Mar 1;179:356-363. (IF 4.916)

64. Gao R,Ma J,Wen Z,Yang P,Zhao J,Xue M,Chen Y,Aldarouish M,Hu HM,Zhu XJ,Pan N,Wang LX

Tumor cell-released autophagosomes (TRAP) enhance apoptosis and immunosuppressive functions of neutrophils.

Oncoimmunology . 2018 Mar 6;7(6):e1438108. (IF 5.333)

65. Gao R,Ma J,Wen Z,Yang P,Zhao J,Xue M,Chen Y,Aldarouish M,Hu HM,Zhu XJ,Pan N,Wang LX

Tumor cell-released autophagosomes (TRAP) enhance apoptosis and immunosuppressive functions of neutrophils.

Oncoimmunology . 2018 Mar 6;7(6):e1438108. (IF 5.333)

66. Li MZ,Zheng LJ,Shen J,Li XY,Zhang Q,Bai X,Wang QS,Ji JG

SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes.

Neural Regen Res . 2018 Nov;13(11):2005-2013. (IF 2.472)

67. Li MZ,Zheng LJ,Shen J,Li XY,Zhang Q,Bai X,Wang QS,Ji JG

SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes.

Neural Regen Res . 2018 Nov;13(11):2005-2013. (IF 2.472)

68. Jiang L,Liang X,Liu G,Zhou Y,Ye X,Chen X,Miao Q,Gao L,Zhang X,Mei L

The mechanism of lauric acid-modified protein nanocapsules escape from intercellular trafficking vesicles and its implication for drug delivery.

Drug Deliv . 2018 Nov;25(1):985-994. (IF 3.829)

69. Qin C,Lv Y,Xu C,Li J,Yin L,He W

Lipid-bilayer-coated nanogels allow for sustained release and enhanced internalization.

INT J PHARMACOL . 2018 Nov 15;551(1-2):8-13. (IF 0.754)

70. Li J,Han Y,Lu Y,Song B,Zhao M,Hu H,Chen D

A novel disulfide bond-mediated cleavable RGD-modified PAMAM nanocomplex containing nuclear localization signal HMGB1 for enhancing gene transfection efficiency.

INT J NANOMED . 2018 Nov 6;13:7135-7153. (IF 4.471)

71. Zhao Q,Zhao H,Guo Y,Zhang Z,Hu Y,Tang Y

Ultra-Rapid Detection of Endogenous Nitric Oxide Based on Fluorescent Conjugated Polymers Probe.

Anal Chem . 2018 Nov 6;90(21):12663-12669. (IF 6.35)

72. Liu Z,Mei T

Immune thrombocytopenia induces autophagy and suppresses apoptosis in megakaryocytes.

Mol Med Rep . 2018 Oct;18(4):4016-4022. (IF 1.851)

73. Yang Y,Gao J,Zhang Y,Xu W,Hao Y,Xu Z,Tao L

Natural pyrethrins induce autophagy of HepG2 cells through the activation of AMPK/mTOR pathway.

Environ Pollut . 2018 Oct;241:1091-1097. (IF 5.714)

74. Chang M,Song X,Geng X,Wang X,Wang W,Chen TC,Xie L,Song X

Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation.

J EXP CLIN CANC RES . 2018 Oct 16;37(1):250. (IF 5.646)

75. Song ZT,Zhang LW,Fan LQ,Kong JW,Mao JH,Zhao J,Wang FJ

Enhanced anticancer effect of MAP30-S3 by cyclosproin A through endosomal escape.

ANTI-CANCER DRUG . 2018 Sep;29(8):736-747. (IF 1.801)

76. Gong X,Sun R,Gao Z,Han W,Liu Y,Zhao L,Jing L,Yao X,Sun X

Tubeimoside 1 Acts as a Chemotherapeutic Synergist via Stimulating Macropinocytosis.

Front Pharmacol . 2018 Sep 26;9:1044. (IF 3.845)

77. Lei P,Tian S,Teng C,Huang L,Liu X,Wang J,Zhang Y,Li B,Shan Y

Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.

Mol Nutr Food Res . 2019 Feb;63(4):e1800795. (IF 4.653)

试剂

核酸相关

多肽与蛋白

细胞相关

信号转导

抗体

抑制剂激活剂等

常用试剂

仪器

耗材

技术服务