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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM5020-5mg | 去氢木香内酯(98%, HPLC) | 5mg | 58.00元 |
| SM5020-10mM | 去氢木香内酯(98%, HPLC) | 10mM×0.2ml | 80.00元 |
| SM5020-25mg | 去氢木香内酯(98%, HPLC) | 25mg | 240.00元 |
| SM5020-100mg | 去氢木香内酯(98%, HPLC) | 100mg | 816.00元 |
化学信息：
| 中文名 | 去氢木香内酯 |
| 英文名 | Dehydrocostus Lactone |
| 中文别名 | - |
| 英文别名 | - |
| 来源 | 木香Aucklandia lappa Decne.；广木香Saussurea lappa Clarke |
| 化合物类型 | 萜类(Terpenoids)>倍半萜>倍半萜内酯 |
| 化学式 | C15H18O2 |
| 分子量 | 230.3 |
| CAS号 | 477-43-0 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | Ethanol: 15 mg/ml (65.13 mM); DMSO: ≥ 62.5 mg/ml (271.39 mM). |
| 溶液配制 | 3mg加入1.30ml DMSO，或者每2.30mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea lappa. | ||||
| 信号通路 | NF-κB; Apoptosis | ||||
| 靶点 | - | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Dehydrocostus Lactone promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced PARP cleavage, decreased Bcl-xL expression and increased levels of Bax, Bak, Bok, Bik, Bmf, and t-Bid. We have demonstrated that Dehydrocostus Lactone inhibits cell growth and induce apoptosis in DU145 cells. Dehydrocostus Lactone inhibits NF-kappaB activation by preventing TNF-alpha-induced degradation and phosphorylation of its inhibitory protein I-kappaB alpha in human leukemia HL-60 cells and that dehydrocostus lactone renders HL-60 cells susceptible to TNF-alpha-induced apoptosis by enhancing caspase-8 and caspase-3 activities. Dehydrocostus Lactone inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. | ||||
| 体内研究 | Dehydrocostus Lactone decreased the TNF-alpha level in LPS-activated systems in vivo. | ||||
| 临床实验 | N/A | ||||
1. Eun Ji Kim, et al. Food and Chemical Toxicology. 2008,46(12):3651–3658.
2. Oh GS, et al. Immunopharmacol Immunotoxicol. 2004,26(2):163-75.
3. Lee HJ, et al. Planta Med. 1999,65(2):104-8.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM5020-10mM | 去氢木香内酯(98%, HPLC) | 10mM×0.2ml |
| SM5020-5mg | 去氢木香内酯(98%, HPLC) | 5mg |
| SM5020-25mg | 去氢木香内酯(98%, HPLC) | 25mg |
| SM5020-100mg | 去氢木香内酯(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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