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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM4080-5mg | 吴茱萸碱(98%, HPLC) | 5mg | 54.00元 |
| SM4080-10mM | 吴茱萸碱(98%, HPLC) | 10mM×0.2ml | 83.00元 |
| SM4080-25mg | 吴茱萸碱(98%, HPLC) | 25mg | 225.00元 |
| SM4080-100mg | 吴茱萸碱(98%, HPLC) | 100mg | 765.00元 |
化学信息：
| 中文名 | 吴茱萸碱 |
| 英文名 | Evodiamine |
| 中文别名 | 吴茱萸胺 |
| 英文别名 | (+)-Evodiamine; d-Evodiamine |
| 来源 | 吴茱萸Euodia rutaecarpa (Juss.) Benth. |
| 化合物类型 | 生物碱(Alkaloids)>色氨吲哚类生物碱 |
| 化学式 | C19H17N3O |
| 分子量 | 303.36 |
| CAS号 | 518-17-2 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 37 mg/ml (121.97 mM) |
| 溶液配制 | 5mg加入1.65ml DMSO，或者每3.03mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor. | ||||
| 信号通路 | Apoptosis; Sphingomyelin; Calcium/JNK; PI3K/Akt/caspase; Fas-L/NF-κB | ||||
| 靶点 | - | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Evodiamine shows cytotoxicity against a variety of human cancer cell-lines by inducing apoptosis. Moreover, it is a naturally multi-targeting antitumor molecule, which exerts the antitumor activity by various molecular mechanism such as caspase-dependent and -independent pathways, sphingomyelin pathway, calcium/JNK signaling, 31 PI3K/Akt/caspase and Fas-L/NF-κB signaling pathways32. | ||||
| 体内研究 | Evodiamine inhibits the metabolism of dapoxetine. Compared to the control group, the pharmacokinetic parameter of t1/2, AUC(0-∞) and Tmax of dapoxetine in evodiamine group is significantly increased by 63.3%, 44.8% and 50.4%, respectively. Moreover, evodiamine has significantly decreased the pharmacokinetic parameter of t1/2 and AUC(0-∞) of desmethyl dapoxetine. Evodiamine suppresses tumor growth in a subcutaneous H22 xenograft model. Evodiamine attenuates VEGF-induced angiogenesis in vivo. | ||||
| 临床实验 | N/A | ||||
1. Wang S, et al. J Med Chem. 2015,58(16):6678-96.
2. Li RF,et al. Pharmacology. 2016,97(1-2):43-7.
3. Shi L, et al. Tumour Biol. 2016,37(9):12791-12803.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4080-10mM | 吴茱萸碱(98%, HPLC) | 10mM×0.2ml |
| SM4080-5mg | 吴茱萸碱(98%, HPLC) | 5mg |
| SM4080-25mg | 吴茱萸碱(98%, HPLC) | 25mg |
| SM4080-100mg | 吴茱萸碱(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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