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抑制剂激活剂等> MAPK与PI3K/Akt通路> SAPK/JNK Signaling
SP600125 (JNK抑制剂)
产品编号: S1876-100mg
产品包装:100mg
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价格: ¥ 2071.00
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产品编号 产品名称 产品包装 产品价格
S1876-5mg SP600125 (JNK抑制剂) 5mg 418.00元
S1876-25mg SP600125 (JNK抑制剂) 25mg 778.00元
S1876-100mg SP600125 (JNK抑制剂) 100mg 2071.00元

SP600125也称Anthrapyrazolone或1,9-Pyrazoloanthrone,是一种常用的c-Jun N-terminal kinase (JNK)的高选择性抑制剂。对于JNK1和JNK2的IC50为40nM,对于JNK3的IC50为90nM。对于JNK的选择性抑制比对于ERK1和p38-MAPK的抑制高300倍以上。在细胞中,SP600125可以显著抑制JNK介导的c-Jun磷酸化,抑制IL-2、IFN-γ、TNF-α和COX2等基因的表达。
SP600125常用于JNK信号途径(JNK signaling pathway)的研究。
SP600125的分子量为220.23,分子式为C14H8N2O,CAS Number:129-56-6。本产品纯度大于98%。
本产品为进口分装,可以溶解于DMSO(溶解度约为15mg/ml),不溶于水。溶解于DMSO配制成的储存液可以在-20度稳定保存2个月。
包装清单:

产品编号 产品名称 包装
S1876-5mg SP600125(JNK抑制剂) 5mg
S1876-25mg SP600125(JNK抑制剂) 25mg
S1876-100mg SP600125(JNK抑制剂) 100mg
说明书 1份

保存条件:
-20℃避光保存,一年有效。
注意事项:
本产品对人体有刺激性,操作时请小心,并注意适当防护以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。 

使用说明:
1. SP600125常见使用浓度范围为1-100μM,最常见的使用浓度为10μM。具体的最佳工作浓度请参考相关文献,或根据实验目的,以及所培养的特定细胞和组织,通过实验进行摸索和优化。
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