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 Caspase抑制剂Z-VAD-FMK

  产品编号C1202-5mg
  产品包装: 5mg
  产品价格: 1628.00元
产品编号 产品名称 产品包装 产品价格
C1202-5mg Caspase抑制剂Z-VAD-FMK 5mg 1628.00元

      Caspase抑制剂Z-VAD-FMK(Caspase Inhibitor Z-VAD-FMK)是一种可以穿透细胞膜的泛Caspase抑制剂(Cell permeable pan caspase inhibitor),可以抑制由Caspase激活导致的细胞凋亡。
      本Caspase抑制剂Z-VAD-FMK是一种不可逆的Caspase广普抑制剂,分子式为Z-Val-Ala-Asp-CH2F,即C21H28FN3O7,分子量为453.5,纯度>95%。
      Caspase抑制剂Z-VAD-FMK是一种最常用的细胞凋亡抑制剂,常用于观察特定的细胞凋亡是否通过Caspase激活来介导。
      Caspase抑制剂Z-VAD-FMK不仅可以穿透细胞膜抑制细胞内的Caspase,也可以用于抑制体外纯化或粗抽提的Caspase。
      本Caspase抑制剂Z-VAD-FMK 20mM包装产品配制在DMSO中,可以直接使用。5mg包装为粉末装。
包装清单:

产品编号 产品名称 包装
C1202-0.02ml Caspase抑制剂Z-VAD-FMK 20mM×0.02ml
C1202-0.1ml Caspase抑制剂Z-VAD-FMK 20mM×0.1ml
C1202-5mg Caspase抑制剂Z-VAD-FMK 5mg
说明书 1份

保存条件:
      -20℃保存,一年有效。
注意事项:
      如果每次使用量少,使用次数较多,请适当分装。反复冻融会影响本抑制剂的使用效果。
      如果希望适当稀释后再分装保存,请使用DMSO进行稀释。
      本Caspase抑制剂Z-VAD-FMK在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内,可以20-25℃水浴温育片刻至全部融解后使用。
      本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
      为了您的安全和健康,请穿实验服并戴一次性手套操作。 

使用说明:
1. Caspase抑制剂Z-VAD-FMK在终浓度为20μM时可以非常显著地抑制大多数细胞凋亡诱导剂诱导的细胞凋亡。Caspase抑制剂Z-VAD-FMK抑制细胞凋亡的常见有效浓度范围为5-100μM。
2. Caspase抑制剂Z-VAD-FMK用于抑制细胞凋亡时至少需要和细胞凋亡诱导剂同时加入,或者需在细胞凋亡诱导剂加入前10-30分钟加入到细胞培养液中,或参考相关文献进行。
3. 如果用于抑制纯化或粗抽提的Caspase,推荐Caspase抑制剂Z-VAD-FMK与待测样品预孵育10-20分钟,再进行后续测定。
相关产品请点击如下按钮:

使用本产品的文献:
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β,β-Dimethylacrylshikonin induces mitochondria dependent apoptosis through ERK pathway in human gastriccancer SGC-7901 cells.
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A Novel Benzothiazole Derivative YLT322 Induces Apoptosis via the Mitochondrial Apoptosis Pathway In Vitrowith Anti-Tumor Activity in Solid Malignancies.
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Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice.
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β, β-Dimethylacrylshikonin induces mitochondria-dependent apoptosis of human lung adenocarcinoma cells in vitro via p38 pathway activation.
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Arsenic trioxide rewires mantle cell lymphoma response to bortezomib.
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Positive Feedback Cycle of TNFα Promotes Staphylococcal Enterotoxin B-Induced THP-1 Cell Apoptosis.
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A new semisynthetic 1-O-acetyl-6-O-lauroylbritannilactone induces apoptosis of humanlaryngocarcinoma cells through p53-dependent pathway.
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Zanthoxylum bungeanum essential oil induces apoptosis of HaCaT human keratinocytes.
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A novel combination of oridonin and valproic acid in enhancement of apoptosis induction of HL-60leukemia cells.
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